Quantitative methods for indirect CT lymphography

Erik R Wisner, J Anthony Seibert, Richard W Katzberg

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


In this investigation, we applied quantitative CT methods to characterize contrast enhanced lymph nodes opacified using iodinated contrast media for indirect CT lymphography. Iodinated nanoparticles were injected into the buccal submucosa and SQ into the metatarsus and metacarpus of four normal swine (1.0-4.0 ml/site, 76 mg I/ml). Attenuation (HU), volume (cm3), iodine concentration (mg I/cm3), total iodine uptake (mg I), contrast-to-noise ratio (CNR), and percent injected dose (%ID) were estimated in opacified inguinal, cervical and parotid/mandibular lymph nodes using manual image segmentation techniques on 24 hour post-contrast CT images, Lymph node volumes estimated by multiple slice ROI analysis were compared with estimates obtained by post-excisional weight measurements. HU and iodine concentration increased 5-20 fold in opacified nodes (p < 0.01) and CNR increased more than four-fold (p < 0.001). %ID ranged between 3.5 and 11.9% and did not appear dose related. ROI estimated lymph node volumes approximated volumes calculated from weight measurements. (R2 = 0.94, p < 0.0001), We conclude that interstitially injected iodinated nanoparticles increase attenuation and conspicuity of targeted nodes on CT images. Quantitative methods could play an important clinical role in more accurate metastasis detection.

Original languageEnglish (US)
Pages (from-to)110-116
Number of pages7
JournalVeterinary Radiology and Ultrasound
Issue number2
StatePublished - Mar 1998


  • Computed tomography
  • Contrast media
  • Iodinated nanoparticle
  • Lymph node
  • Lymphography
  • Quantitative methods

ASJC Scopus subject areas

  • veterinary(all)


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