Quantitative measurements of cerebral blood flow in volume imaging PET scanners

R. J. Smith, L. Shao, R. Freifelder, J. S. Karp, John D Ragland

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Quantitative measurements of Cerebral Blood Flow (CBF) are performed in a volume imaging PET Scanner by means of moderate activity infusions. In equilibrium infusions, activations are measured by scanning over 10 minutes with 16 minute activations. Typical measured whole brain CBF values are 37 ± 8 ml/min/100g, close to the value of 42 ml/min/100g reported by other groups using this method. For ramped infusions, scanning over 4 minutes with 5 minute activations results in whole brain CBFs of 49 ± 9 ml/min/100g, close to the Kety and Schmidt value of 50 ml/min/100g. Both equilibrium and ramped infusion methods have been used to study face and word memory in human subjects. Both methods were able to detect significant activations in regions implicated in human memory. We conclude that precise quantitation of regional CBF is achieved using both methods, and that ramped infusions also provide accurate measures of CBF. In addition a simplified protocol for ramped infusion studies has been developed. In this method the whole brain tissue time activity curve generated from dynamic scanning is replaced by an appropriately scaled camera coincidence countrate curve. The resulting whole brain CBF values are only 7% different from the dynamic scan and fit results. Regional CBFs (rCBF) may then be generated from the summed image (4.25 minutes) using a count density vs flow lookup table.

Original languageEnglish (US)
Pages (from-to)1018-1023
Number of pages6
JournalIEEE Transactions on Nuclear Science
Volume42
Issue number4 pt 1
StatePublished - Aug 1995
Externally publishedYes

Fingerprint

blood flow
scanners
Blood
brain
Brain
Imaging techniques
Chemical activation
activation
Scanning
scanning
Data storage equipment
Table lookup
curves
Cameras
cameras
Tissue

ASJC Scopus subject areas

  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering

Cite this

Quantitative measurements of cerebral blood flow in volume imaging PET scanners. / Smith, R. J.; Shao, L.; Freifelder, R.; Karp, J. S.; Ragland, John D.

In: IEEE Transactions on Nuclear Science, Vol. 42, No. 4 pt 1, 08.1995, p. 1018-1023.

Research output: Contribution to journalArticle

Smith, RJ, Shao, L, Freifelder, R, Karp, JS & Ragland, JD 1995, 'Quantitative measurements of cerebral blood flow in volume imaging PET scanners', IEEE Transactions on Nuclear Science, vol. 42, no. 4 pt 1, pp. 1018-1023.
Smith, R. J. ; Shao, L. ; Freifelder, R. ; Karp, J. S. ; Ragland, John D. / Quantitative measurements of cerebral blood flow in volume imaging PET scanners. In: IEEE Transactions on Nuclear Science. 1995 ; Vol. 42, No. 4 pt 1. pp. 1018-1023.
@article{a4a8f61adfff44eea546291aee57e8fd,
title = "Quantitative measurements of cerebral blood flow in volume imaging PET scanners",
abstract = "Quantitative measurements of Cerebral Blood Flow (CBF) are performed in a volume imaging PET Scanner by means of moderate activity infusions. In equilibrium infusions, activations are measured by scanning over 10 minutes with 16 minute activations. Typical measured whole brain CBF values are 37 ± 8 ml/min/100g, close to the value of 42 ml/min/100g reported by other groups using this method. For ramped infusions, scanning over 4 minutes with 5 minute activations results in whole brain CBFs of 49 ± 9 ml/min/100g, close to the Kety and Schmidt value of 50 ml/min/100g. Both equilibrium and ramped infusion methods have been used to study face and word memory in human subjects. Both methods were able to detect significant activations in regions implicated in human memory. We conclude that precise quantitation of regional CBF is achieved using both methods, and that ramped infusions also provide accurate measures of CBF. In addition a simplified protocol for ramped infusion studies has been developed. In this method the whole brain tissue time activity curve generated from dynamic scanning is replaced by an appropriately scaled camera coincidence countrate curve. The resulting whole brain CBF values are only 7{\%} different from the dynamic scan and fit results. Regional CBFs (rCBF) may then be generated from the summed image (4.25 minutes) using a count density vs flow lookup table.",
author = "Smith, {R. J.} and L. Shao and R. Freifelder and Karp, {J. S.} and Ragland, {John D}",
year = "1995",
month = "8",
language = "English (US)",
volume = "42",
pages = "1018--1023",
journal = "IEEE Transactions on Nuclear Science",
issn = "0018-9499",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
number = "4 pt 1",

}

TY - JOUR

T1 - Quantitative measurements of cerebral blood flow in volume imaging PET scanners

AU - Smith, R. J.

AU - Shao, L.

AU - Freifelder, R.

AU - Karp, J. S.

AU - Ragland, John D

PY - 1995/8

Y1 - 1995/8

N2 - Quantitative measurements of Cerebral Blood Flow (CBF) are performed in a volume imaging PET Scanner by means of moderate activity infusions. In equilibrium infusions, activations are measured by scanning over 10 minutes with 16 minute activations. Typical measured whole brain CBF values are 37 ± 8 ml/min/100g, close to the value of 42 ml/min/100g reported by other groups using this method. For ramped infusions, scanning over 4 minutes with 5 minute activations results in whole brain CBFs of 49 ± 9 ml/min/100g, close to the Kety and Schmidt value of 50 ml/min/100g. Both equilibrium and ramped infusion methods have been used to study face and word memory in human subjects. Both methods were able to detect significant activations in regions implicated in human memory. We conclude that precise quantitation of regional CBF is achieved using both methods, and that ramped infusions also provide accurate measures of CBF. In addition a simplified protocol for ramped infusion studies has been developed. In this method the whole brain tissue time activity curve generated from dynamic scanning is replaced by an appropriately scaled camera coincidence countrate curve. The resulting whole brain CBF values are only 7% different from the dynamic scan and fit results. Regional CBFs (rCBF) may then be generated from the summed image (4.25 minutes) using a count density vs flow lookup table.

AB - Quantitative measurements of Cerebral Blood Flow (CBF) are performed in a volume imaging PET Scanner by means of moderate activity infusions. In equilibrium infusions, activations are measured by scanning over 10 minutes with 16 minute activations. Typical measured whole brain CBF values are 37 ± 8 ml/min/100g, close to the value of 42 ml/min/100g reported by other groups using this method. For ramped infusions, scanning over 4 minutes with 5 minute activations results in whole brain CBFs of 49 ± 9 ml/min/100g, close to the Kety and Schmidt value of 50 ml/min/100g. Both equilibrium and ramped infusion methods have been used to study face and word memory in human subjects. Both methods were able to detect significant activations in regions implicated in human memory. We conclude that precise quantitation of regional CBF is achieved using both methods, and that ramped infusions also provide accurate measures of CBF. In addition a simplified protocol for ramped infusion studies has been developed. In this method the whole brain tissue time activity curve generated from dynamic scanning is replaced by an appropriately scaled camera coincidence countrate curve. The resulting whole brain CBF values are only 7% different from the dynamic scan and fit results. Regional CBFs (rCBF) may then be generated from the summed image (4.25 minutes) using a count density vs flow lookup table.

UR - http://www.scopus.com/inward/record.url?scp=0029359376&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029359376&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0029359376

VL - 42

SP - 1018

EP - 1023

JO - IEEE Transactions on Nuclear Science

JF - IEEE Transactions on Nuclear Science

SN - 0018-9499

IS - 4 pt 1

ER -