Quantitative in vivo measurements of tumor perfusion using rubidium-18 and positron emission tomography

Simon R Cherry, P. Carnochan, J. W. Babich, F. Serafini, N. P. Rowell, I. A. Watson

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Rubidium-81 (t( 1/2 ) = 4.58 hr) was investigated as a tumor perfusion tracer in the VX2 carcinoma implanted into rabbit thigh muscle using a large-area, multiwire proportional chamber positron emission tomography (PET) system. Perfusion was determined using the arterial reference sample method, and the results from PET imaging were compared with postmortem tissue sampling. Absolute quantitation of tumor perfusion was achieved using external probes to estimate local extraction fraction. Redistribution of rubidium-81 (81Rb) was investigated using a dual-tracer technique. Average perfusion was found to be 13.5 and 3.7 ml/min/100 g in tumor and normal muscle, respectively. The extraction fraction as estimated from a two-compartment model ranged from 0.94 to 1.00. No significant redistribution of 81Rb was observed in these tissues. Nine patients with malignancies were studied using 81Rb and PET. Tumor perfusion in four patients with carcinoma of the breast was elevated by a factor of 1.8 (range 1.2-2.3) compared to contralateral normal breast.

Original languageEnglish (US)
Pages (from-to)1307-1315
Number of pages9
JournalJournal of Nuclear Medicine
Volume31
Issue number8
StatePublished - 1990

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Rubidium
Positron-Emission Tomography
Perfusion
Neoplasms
Muscles
Thigh
Breast
Breast Neoplasms
Rabbits
Carcinoma

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Cherry, S. R., Carnochan, P., Babich, J. W., Serafini, F., Rowell, N. P., & Watson, I. A. (1990). Quantitative in vivo measurements of tumor perfusion using rubidium-18 and positron emission tomography. Journal of Nuclear Medicine, 31(8), 1307-1315.

Quantitative in vivo measurements of tumor perfusion using rubidium-18 and positron emission tomography. / Cherry, Simon R; Carnochan, P.; Babich, J. W.; Serafini, F.; Rowell, N. P.; Watson, I. A.

In: Journal of Nuclear Medicine, Vol. 31, No. 8, 1990, p. 1307-1315.

Research output: Contribution to journalArticle

Cherry, SR, Carnochan, P, Babich, JW, Serafini, F, Rowell, NP & Watson, IA 1990, 'Quantitative in vivo measurements of tumor perfusion using rubidium-18 and positron emission tomography', Journal of Nuclear Medicine, vol. 31, no. 8, pp. 1307-1315.
Cherry, Simon R ; Carnochan, P. ; Babich, J. W. ; Serafini, F. ; Rowell, N. P. ; Watson, I. A. / Quantitative in vivo measurements of tumor perfusion using rubidium-18 and positron emission tomography. In: Journal of Nuclear Medicine. 1990 ; Vol. 31, No. 8. pp. 1307-1315.
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AU - Watson, I. A.

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