Abstract
Rationale: Human immunodeficiency virus (HIV) infection has a major but unquantified impact on the risk of tuberculosis. Objectives: To quantify the impact of HIV infection on the number of tuberculosis cases in San Francisco. Methods: We studied all patients reported with tuberculosis in San Francisco from 1991 to 2002. The initial isolates of Mycobacterium tuberculosis were genotyped using IS6110 restriction fragment-length polymorphism genotyping as the primary method, and clustered cases (identical genotype patterns) were identified. Measurements and Main Results: We determined the case number, case rate, and the fraction of tuberculosis attributable to HIV infection. Of 2,991 reported tuberculosis cases, 2,193 (73.3%) had a genotype pattern of M. tuberculosis available. Genotypic clusters with at least one HIV-positive person were larger, lasted longer, and had a shorter time between successive cases relative to clusters with only HIV-uninfected persons (P < 0.00005, P = 0.0009, P = 0.018, respectively). Overall, 13.7% of the tuberculosis cases were attributable to HIV infection and an estimated 405 excess tuberculosis cases occurred. Conclusions: During a period encompassing the resurgence and decline of tuberculosis in San Francisco, a substantial number of the tuberculosis cases were attributable to HIV infection. Coinfection with HIV amplified the local tuberculosis epidemic.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 936-944 |
| Number of pages | 9 |
| Journal | American Journal of Respiratory and Critical Care Medicine |
| Volume | 176 |
| Issue number | 9 |
| DOIs | |
| State | Published - Nov 1 2007 |
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Keywords
- Genotyping
- HIV infection
- Transmission
- Tuberculosis
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Quantitative impact of human immunodeficiency virus infection on tuberculosis dynamics. / DeRiemer, Kathryn; Kawamura, L. Masae; Hopewell, Philip C.; Daley, Charles L.
In: American Journal of Respiratory and Critical Care Medicine, Vol. 176, No. 9, 01.11.2007, p. 936-944.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Quantitative impact of human immunodeficiency virus infection on tuberculosis dynamics
AU - DeRiemer, Kathryn
AU - Kawamura, L. Masae
AU - Hopewell, Philip C.
AU - Daley, Charles L.
PY - 2007/11/1
Y1 - 2007/11/1
N2 - Rationale: Human immunodeficiency virus (HIV) infection has a major but unquantified impact on the risk of tuberculosis. Objectives: To quantify the impact of HIV infection on the number of tuberculosis cases in San Francisco. Methods: We studied all patients reported with tuberculosis in San Francisco from 1991 to 2002. The initial isolates of Mycobacterium tuberculosis were genotyped using IS6110 restriction fragment-length polymorphism genotyping as the primary method, and clustered cases (identical genotype patterns) were identified. Measurements and Main Results: We determined the case number, case rate, and the fraction of tuberculosis attributable to HIV infection. Of 2,991 reported tuberculosis cases, 2,193 (73.3%) had a genotype pattern of M. tuberculosis available. Genotypic clusters with at least one HIV-positive person were larger, lasted longer, and had a shorter time between successive cases relative to clusters with only HIV-uninfected persons (P < 0.00005, P = 0.0009, P = 0.018, respectively). Overall, 13.7% of the tuberculosis cases were attributable to HIV infection and an estimated 405 excess tuberculosis cases occurred. Conclusions: During a period encompassing the resurgence and decline of tuberculosis in San Francisco, a substantial number of the tuberculosis cases were attributable to HIV infection. Coinfection with HIV amplified the local tuberculosis epidemic.
AB - Rationale: Human immunodeficiency virus (HIV) infection has a major but unquantified impact on the risk of tuberculosis. Objectives: To quantify the impact of HIV infection on the number of tuberculosis cases in San Francisco. Methods: We studied all patients reported with tuberculosis in San Francisco from 1991 to 2002. The initial isolates of Mycobacterium tuberculosis were genotyped using IS6110 restriction fragment-length polymorphism genotyping as the primary method, and clustered cases (identical genotype patterns) were identified. Measurements and Main Results: We determined the case number, case rate, and the fraction of tuberculosis attributable to HIV infection. Of 2,991 reported tuberculosis cases, 2,193 (73.3%) had a genotype pattern of M. tuberculosis available. Genotypic clusters with at least one HIV-positive person were larger, lasted longer, and had a shorter time between successive cases relative to clusters with only HIV-uninfected persons (P < 0.00005, P = 0.0009, P = 0.018, respectively). Overall, 13.7% of the tuberculosis cases were attributable to HIV infection and an estimated 405 excess tuberculosis cases occurred. Conclusions: During a period encompassing the resurgence and decline of tuberculosis in San Francisco, a substantial number of the tuberculosis cases were attributable to HIV infection. Coinfection with HIV amplified the local tuberculosis epidemic.
KW - Genotyping
KW - HIV infection
KW - Transmission
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=36048971191&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36048971191&partnerID=8YFLogxK
U2 - 10.1164/rccm.200603-440OC
DO - 10.1164/rccm.200603-440OC
M3 - Article
C2 - 17690336
AN - SCOPUS:36048971191
VL - 176
SP - 936
EP - 944
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
SN - 1073-449X
IS - 9
ER -