Quantitative computer tomography in Alzheimer's disease: A re-evaluation

S. A. Koslow, A. A. Swihart, Richard E Latchaw, W. L. Hirsch, S. H. Belle, Y. K. Shim, F. Boller

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

This investigation addresses the question of usefulness of computer-tomographic (CT) scanning in discriminating patients with Alzheimer's disease (AD) from healthy, aged controls. Quantitative measures of brain volume loss found to be significant by other investigators as well as additional unique variables are used to discriminate 58 longitudinally studied patients meeting NINCDS-ADRDA criteria for the clinical diagnosis of probable AD from 59 controls. The sensitivity and specificity of both single CT scan parameters and multivariate models comprised of such CT parameters are explored. Reasons for diagnostic misclassification are also illuminated.

Original languageEnglish (US)
Pages (from-to)174-184
Number of pages11
JournalGerontology
Volume38
Issue number3
StatePublished - 1992
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Computer tomography
  • Dementia

ASJC Scopus subject areas

  • Aging

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  • Cite this

    Koslow, S. A., Swihart, A. A., Latchaw, R. E., Hirsch, W. L., Belle, S. H., Shim, Y. K., & Boller, F. (1992). Quantitative computer tomography in Alzheimer's disease: A re-evaluation. Gerontology, 38(3), 174-184.