Quantitative computer tomography in Alzheimer's disease: A re-evaluation

S. A. Koslow; A. A. Swihart; Richard E Latchaw; W. L. Hirsch; S. H. Belle; Y. K. Shim; F. Boller

Quantitative computer tomography in Alzheimer's disease: A re-evaluation

S. A. Koslow, A. A. Swihart, Richard E Latchaw, W. L. Hirsch, S. H. Belle, Y. K. Shim, F. Boller

Research output: Contribution to journal › Article › peer-review

Abstract

This investigation addresses the question of usefulness of computer-tomographic (CT) scanning in discriminating patients with Alzheimer's disease (AD) from healthy, aged controls. Quantitative measures of brain volume loss found to be significant by other investigators as well as additional unique variables are used to discriminate 58 longitudinally studied patients meeting NINCDS-ADRDA criteria for the clinical diagnosis of probable AD from 59 controls. The sensitivity and specificity of both single CT scan parameters and multivariate models comprised of such CT parameters are explored. Reasons for diagnostic misclassification are also illuminated.

Original language	English (US)
Pages (from-to)	174-184
Number of pages	11
Journal	Gerontology
Volume	38
Issue number	3
State	Published - 1992
Externally published	Yes

Keywords

Alzheimer's disease
Computer tomography
Dementia

ASJC Scopus subject areas

Aging

Cite this

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title = "Quantitative computer tomography in Alzheimer's disease: A re-evaluation",

abstract = "This investigation addresses the question of usefulness of computer-tomographic (CT) scanning in discriminating patients with Alzheimer's disease (AD) from healthy, aged controls. Quantitative measures of brain volume loss found to be significant by other investigators as well as additional unique variables are used to discriminate 58 longitudinally studied patients meeting NINCDS-ADRDA criteria for the clinical diagnosis of probable AD from 59 controls. The sensitivity and specificity of both single CT scan parameters and multivariate models comprised of such CT parameters are explored. Reasons for diagnostic misclassification are also illuminated.",

keywords = "Alzheimer's disease, Computer tomography, Dementia",

author = "Koslow, {S. A.} and Swihart, {A. A.} and Latchaw, {Richard E} and Hirsch, {W. L.} and Belle, {S. H.} and Shim, {Y. K.} and F. Boller",

year = "1992",

language = "English (US)",

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pages = "174--184",

journal = "Gerontology",

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T2 - A re-evaluation

AU - Koslow, S. A.

AU - Swihart, A. A.

AU - Latchaw, Richard E

AU - Hirsch, W. L.

AU - Belle, S. H.

AU - Shim, Y. K.

AU - Boller, F.

PY - 1992

Y1 - 1992

N2 - This investigation addresses the question of usefulness of computer-tomographic (CT) scanning in discriminating patients with Alzheimer's disease (AD) from healthy, aged controls. Quantitative measures of brain volume loss found to be significant by other investigators as well as additional unique variables are used to discriminate 58 longitudinally studied patients meeting NINCDS-ADRDA criteria for the clinical diagnosis of probable AD from 59 controls. The sensitivity and specificity of both single CT scan parameters and multivariate models comprised of such CT parameters are explored. Reasons for diagnostic misclassification are also illuminated.

AB - This investigation addresses the question of usefulness of computer-tomographic (CT) scanning in discriminating patients with Alzheimer's disease (AD) from healthy, aged controls. Quantitative measures of brain volume loss found to be significant by other investigators as well as additional unique variables are used to discriminate 58 longitudinally studied patients meeting NINCDS-ADRDA criteria for the clinical diagnosis of probable AD from 59 controls. The sensitivity and specificity of both single CT scan parameters and multivariate models comprised of such CT parameters are explored. Reasons for diagnostic misclassification are also illuminated.

KW - Alzheimer's disease

KW - Computer tomography

KW - Dementia

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EP - 184

JO - Gerontology

JF - Gerontology

SN - 0304-324X

IS - 3

ER -

Quantitative computer tomography in Alzheimer's disease: A re-evaluation

Abstract

Keywords

ASJC Scopus subject areas

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