Quantitative bremsstrahlung imaging of yttrium-90 using a wiener

Sui Shen, Gerald L Denardo, Sally J. DeNardo

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Yttrium-90 (90Y), a pure beta emitter, is an attractive radionuclide for radioimmunotherapy of cancer. Therapeutic management requires quantitative imaging to measure the pharmacokinetics of the radionuclide in the patient for radiation dosimetric calculations. The bremsstrahlung emissions can be utilized to acquire an image of beta sources using a gamma camera. Quantitation of by 9°Y bremsstrahlung imaging is difficult because of poor image quality that results from septal penetration and scatter secondary to the broad bremsstrahlung energies. In this work, quantitative methods for bremsstrahlung imaging of 90Y sources that involved the use of (a) a Wiener filter to deconvolve the septal penetration and scatter while suppressing image noise, and (b) the geometric mean of the conjugate view (GM) and effective point source (EPS) methods to quantify activities were investigated. An abdominal phantom was prepared with 90Y activities in the liver, spleen, tumors, and background volumes that were similar to those observed in patient studies. A twofold improvement in resolution recovery for full width at tenth maximum of the line spread function at 11 cm depth in water was achieved using Wiener restoration. Definition of the organ and tumor edges was greatly enhanced and cross talk between adjacent sources was suppressed after Wiener restoration. These improvements in image quality led to more accurate estimation of organ and tumor activities. Using the optimum attenuation correction method for GM and EPS quantitation of filtered bremsstrahlung images, estimates of individual activities (17% error) and cumulated activities (8% error) in all of the sources were accurate except for a tumor of 2 cm diameter. The results of this study provide the basis for a method to quantify beta source distribution and demonstrate the potential use of bremsstrahlung imaging in clinical settings.

Original languageEnglish (US)
Pages (from-to)1409-1417
Number of pages9
JournalMedical Physics
Volume21
Issue number9
DOIs
StatePublished - 1994

Fingerprint

Yttrium
Radioisotopes
Neoplasms
Radioimmunotherapy
Gamma Cameras
Tumor Burden
Spleen
Pharmacokinetics
Radiation
Water
Liver
Therapeutics

Keywords

  • quantitative imaging
  • radioimmunotherapy
  • Wiener filter
  • yttrium-90

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Quantitative bremsstrahlung imaging of yttrium-90 using a wiener. / Shen, Sui; Denardo, Gerald L; DeNardo, Sally J.

In: Medical Physics, Vol. 21, No. 9, 1994, p. 1409-1417.

Research output: Contribution to journalArticle

Shen, Sui ; Denardo, Gerald L ; DeNardo, Sally J. / Quantitative bremsstrahlung imaging of yttrium-90 using a wiener. In: Medical Physics. 1994 ; Vol. 21, No. 9. pp. 1409-1417.
@article{8c48623755814683a52a9f0883593d98,
title = "Quantitative bremsstrahlung imaging of yttrium-90 using a wiener",
abstract = "Yttrium-90 (90Y), a pure beta emitter, is an attractive radionuclide for radioimmunotherapy of cancer. Therapeutic management requires quantitative imaging to measure the pharmacokinetics of the radionuclide in the patient for radiation dosimetric calculations. The bremsstrahlung emissions can be utilized to acquire an image of beta sources using a gamma camera. Quantitation of by 9°Y bremsstrahlung imaging is difficult because of poor image quality that results from septal penetration and scatter secondary to the broad bremsstrahlung energies. In this work, quantitative methods for bremsstrahlung imaging of 90Y sources that involved the use of (a) a Wiener filter to deconvolve the septal penetration and scatter while suppressing image noise, and (b) the geometric mean of the conjugate view (GM) and effective point source (EPS) methods to quantify activities were investigated. An abdominal phantom was prepared with 90Y activities in the liver, spleen, tumors, and background volumes that were similar to those observed in patient studies. A twofold improvement in resolution recovery for full width at tenth maximum of the line spread function at 11 cm depth in water was achieved using Wiener restoration. Definition of the organ and tumor edges was greatly enhanced and cross talk between adjacent sources was suppressed after Wiener restoration. These improvements in image quality led to more accurate estimation of organ and tumor activities. Using the optimum attenuation correction method for GM and EPS quantitation of filtered bremsstrahlung images, estimates of individual activities (17{\%} error) and cumulated activities (8{\%} error) in all of the sources were accurate except for a tumor of 2 cm diameter. The results of this study provide the basis for a method to quantify beta source distribution and demonstrate the potential use of bremsstrahlung imaging in clinical settings.",
keywords = "quantitative imaging, radioimmunotherapy, Wiener filter, yttrium-90",
author = "Sui Shen and Denardo, {Gerald L} and DeNardo, {Sally J.}",
year = "1994",
doi = "10.1118/1.597198",
language = "English (US)",
volume = "21",
pages = "1409--1417",
journal = "Medical Physics",
issn = "0094-2405",
publisher = "AAPM - American Association of Physicists in Medicine",
number = "9",

}

TY - JOUR

T1 - Quantitative bremsstrahlung imaging of yttrium-90 using a wiener

AU - Shen, Sui

AU - Denardo, Gerald L

AU - DeNardo, Sally J.

PY - 1994

Y1 - 1994

N2 - Yttrium-90 (90Y), a pure beta emitter, is an attractive radionuclide for radioimmunotherapy of cancer. Therapeutic management requires quantitative imaging to measure the pharmacokinetics of the radionuclide in the patient for radiation dosimetric calculations. The bremsstrahlung emissions can be utilized to acquire an image of beta sources using a gamma camera. Quantitation of by 9°Y bremsstrahlung imaging is difficult because of poor image quality that results from septal penetration and scatter secondary to the broad bremsstrahlung energies. In this work, quantitative methods for bremsstrahlung imaging of 90Y sources that involved the use of (a) a Wiener filter to deconvolve the septal penetration and scatter while suppressing image noise, and (b) the geometric mean of the conjugate view (GM) and effective point source (EPS) methods to quantify activities were investigated. An abdominal phantom was prepared with 90Y activities in the liver, spleen, tumors, and background volumes that were similar to those observed in patient studies. A twofold improvement in resolution recovery for full width at tenth maximum of the line spread function at 11 cm depth in water was achieved using Wiener restoration. Definition of the organ and tumor edges was greatly enhanced and cross talk between adjacent sources was suppressed after Wiener restoration. These improvements in image quality led to more accurate estimation of organ and tumor activities. Using the optimum attenuation correction method for GM and EPS quantitation of filtered bremsstrahlung images, estimates of individual activities (17% error) and cumulated activities (8% error) in all of the sources were accurate except for a tumor of 2 cm diameter. The results of this study provide the basis for a method to quantify beta source distribution and demonstrate the potential use of bremsstrahlung imaging in clinical settings.

AB - Yttrium-90 (90Y), a pure beta emitter, is an attractive radionuclide for radioimmunotherapy of cancer. Therapeutic management requires quantitative imaging to measure the pharmacokinetics of the radionuclide in the patient for radiation dosimetric calculations. The bremsstrahlung emissions can be utilized to acquire an image of beta sources using a gamma camera. Quantitation of by 9°Y bremsstrahlung imaging is difficult because of poor image quality that results from septal penetration and scatter secondary to the broad bremsstrahlung energies. In this work, quantitative methods for bremsstrahlung imaging of 90Y sources that involved the use of (a) a Wiener filter to deconvolve the septal penetration and scatter while suppressing image noise, and (b) the geometric mean of the conjugate view (GM) and effective point source (EPS) methods to quantify activities were investigated. An abdominal phantom was prepared with 90Y activities in the liver, spleen, tumors, and background volumes that were similar to those observed in patient studies. A twofold improvement in resolution recovery for full width at tenth maximum of the line spread function at 11 cm depth in water was achieved using Wiener restoration. Definition of the organ and tumor edges was greatly enhanced and cross talk between adjacent sources was suppressed after Wiener restoration. These improvements in image quality led to more accurate estimation of organ and tumor activities. Using the optimum attenuation correction method for GM and EPS quantitation of filtered bremsstrahlung images, estimates of individual activities (17% error) and cumulated activities (8% error) in all of the sources were accurate except for a tumor of 2 cm diameter. The results of this study provide the basis for a method to quantify beta source distribution and demonstrate the potential use of bremsstrahlung imaging in clinical settings.

KW - quantitative imaging

KW - radioimmunotherapy

KW - Wiener filter

KW - yttrium-90

UR - http://www.scopus.com/inward/record.url?scp=0027937092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027937092&partnerID=8YFLogxK

U2 - 10.1118/1.597198

DO - 10.1118/1.597198

M3 - Article

C2 - 7838052

AN - SCOPUS:0027937092

VL - 21

SP - 1409

EP - 1417

JO - Medical Physics

JF - Medical Physics

SN - 0094-2405

IS - 9

ER -