Quantitative brain measurements in community-dwelling elderly persons with mild parkinsonian signs

Elan D. Louis, Adam M. Brickman, Charles DeCarli, Scott A. Small, Karen Marder, Nicole Schupf, Truman R. Brown

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Mild parkinsonian signs (MPS) are a marker of incident dementia. They have been linked with cerebrovascular disease, which can be evaluated using magnetic resonance imaging (MRI). Also, if MPS are a marker for developing Alzheimer-type changes, hippocampal volume on MRI might be diminished in individuals with MPS. Objective: To examine white matter hyperintensity (WMH) volume and total hippocampal volume in elderly individuals with and without MPS. Methods: Community-dwelling elderly persons in northern Manhattan (New York), New York, underwent neurologic examination and brain MRI. The WMH volume (derived from fluid-attenuated inversion recovery-weighted MRIs using a semiautomated thresholding approach) and total hippocampal volume (derived manually) were expressed relative to total cranial volume. Results: Mild parkinsonian signs were present in 111 of 666 participants (16.7%). Mean (SD) relative WMH volume was larger in participants with MPS vs those without MPS (1.70 [1.28] vs 1.17 [1.18]; P<.001). In a multivariate logistic regression analysis adjusting for age, sex, race/ethnicity, years of educational achievement, and depression, relative WMH volume was associated with MPS (odds ratio, 1.26; 95% confidence interval, 1.08-1.47; P=.004). In both unadjusted and adjusted analyses, total relative hippocampal volume was similar in participants with MPS vs those without MPS regardless of cognitive status. Conclusions: In this MRI study of community-dwelling elderly persons, WMH volume was associated with MPS and total relative hippocampal volume was not. These data raise the possibility that vascular disease could have a role in the development of MPS.

Original languageEnglish (US)
Pages (from-to)1649-1654
Number of pages6
JournalArchives of Neurology
Volume65
Issue number12
DOIs
StatePublished - Dec 2008

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Independent Living
Magnetic Resonance Imaging
Brain
Cerebrovascular Disorders
Educational Status
Neurologic Examination
Vascular Diseases
Dementia
Logistic Models
Odds Ratio
Regression Analysis
White Matter
Person
Dwelling
Confidence Intervals
Depression

ASJC Scopus subject areas

  • Clinical Neurology

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Quantitative brain measurements in community-dwelling elderly persons with mild parkinsonian signs. / Louis, Elan D.; Brickman, Adam M.; DeCarli, Charles; Small, Scott A.; Marder, Karen; Schupf, Nicole; Brown, Truman R.

In: Archives of Neurology, Vol. 65, No. 12, 12.2008, p. 1649-1654.

Research output: Contribution to journalArticle

Louis, Elan D. ; Brickman, Adam M. ; DeCarli, Charles ; Small, Scott A. ; Marder, Karen ; Schupf, Nicole ; Brown, Truman R. / Quantitative brain measurements in community-dwelling elderly persons with mild parkinsonian signs. In: Archives of Neurology. 2008 ; Vol. 65, No. 12. pp. 1649-1654.
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abstract = "Background: Mild parkinsonian signs (MPS) are a marker of incident dementia. They have been linked with cerebrovascular disease, which can be evaluated using magnetic resonance imaging (MRI). Also, if MPS are a marker for developing Alzheimer-type changes, hippocampal volume on MRI might be diminished in individuals with MPS. Objective: To examine white matter hyperintensity (WMH) volume and total hippocampal volume in elderly individuals with and without MPS. Methods: Community-dwelling elderly persons in northern Manhattan (New York), New York, underwent neurologic examination and brain MRI. The WMH volume (derived from fluid-attenuated inversion recovery-weighted MRIs using a semiautomated thresholding approach) and total hippocampal volume (derived manually) were expressed relative to total cranial volume. Results: Mild parkinsonian signs were present in 111 of 666 participants (16.7{\%}). Mean (SD) relative WMH volume was larger in participants with MPS vs those without MPS (1.70 [1.28] vs 1.17 [1.18]; P<.001). In a multivariate logistic regression analysis adjusting for age, sex, race/ethnicity, years of educational achievement, and depression, relative WMH volume was associated with MPS (odds ratio, 1.26; 95{\%} confidence interval, 1.08-1.47; P=.004). In both unadjusted and adjusted analyses, total relative hippocampal volume was similar in participants with MPS vs those without MPS regardless of cognitive status. Conclusions: In this MRI study of community-dwelling elderly persons, WMH volume was associated with MPS and total relative hippocampal volume was not. These data raise the possibility that vascular disease could have a role in the development of MPS.",
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AU - DeCarli, Charles

AU - Small, Scott A.

AU - Marder, Karen

AU - Schupf, Nicole

AU - Brown, Truman R.

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N2 - Background: Mild parkinsonian signs (MPS) are a marker of incident dementia. They have been linked with cerebrovascular disease, which can be evaluated using magnetic resonance imaging (MRI). Also, if MPS are a marker for developing Alzheimer-type changes, hippocampal volume on MRI might be diminished in individuals with MPS. Objective: To examine white matter hyperintensity (WMH) volume and total hippocampal volume in elderly individuals with and without MPS. Methods: Community-dwelling elderly persons in northern Manhattan (New York), New York, underwent neurologic examination and brain MRI. The WMH volume (derived from fluid-attenuated inversion recovery-weighted MRIs using a semiautomated thresholding approach) and total hippocampal volume (derived manually) were expressed relative to total cranial volume. Results: Mild parkinsonian signs were present in 111 of 666 participants (16.7%). Mean (SD) relative WMH volume was larger in participants with MPS vs those without MPS (1.70 [1.28] vs 1.17 [1.18]; P<.001). In a multivariate logistic regression analysis adjusting for age, sex, race/ethnicity, years of educational achievement, and depression, relative WMH volume was associated with MPS (odds ratio, 1.26; 95% confidence interval, 1.08-1.47; P=.004). In both unadjusted and adjusted analyses, total relative hippocampal volume was similar in participants with MPS vs those without MPS regardless of cognitive status. Conclusions: In this MRI study of community-dwelling elderly persons, WMH volume was associated with MPS and total relative hippocampal volume was not. These data raise the possibility that vascular disease could have a role in the development of MPS.

AB - Background: Mild parkinsonian signs (MPS) are a marker of incident dementia. They have been linked with cerebrovascular disease, which can be evaluated using magnetic resonance imaging (MRI). Also, if MPS are a marker for developing Alzheimer-type changes, hippocampal volume on MRI might be diminished in individuals with MPS. Objective: To examine white matter hyperintensity (WMH) volume and total hippocampal volume in elderly individuals with and without MPS. Methods: Community-dwelling elderly persons in northern Manhattan (New York), New York, underwent neurologic examination and brain MRI. The WMH volume (derived from fluid-attenuated inversion recovery-weighted MRIs using a semiautomated thresholding approach) and total hippocampal volume (derived manually) were expressed relative to total cranial volume. Results: Mild parkinsonian signs were present in 111 of 666 participants (16.7%). Mean (SD) relative WMH volume was larger in participants with MPS vs those without MPS (1.70 [1.28] vs 1.17 [1.18]; P<.001). In a multivariate logistic regression analysis adjusting for age, sex, race/ethnicity, years of educational achievement, and depression, relative WMH volume was associated with MPS (odds ratio, 1.26; 95% confidence interval, 1.08-1.47; P=.004). In both unadjusted and adjusted analyses, total relative hippocampal volume was similar in participants with MPS vs those without MPS regardless of cognitive status. Conclusions: In this MRI study of community-dwelling elderly persons, WMH volume was associated with MPS and total relative hippocampal volume was not. These data raise the possibility that vascular disease could have a role in the development of MPS.

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