Quantitative assessment of ventilation-perfusion relationships with gallium-68 positron emission tomography/computed tomography imaging in lung cancer patients

Zhuorui Li, Pierre Yves Le Roux, Jason Callahan, Nicholas Hardcastle, Michael S. Hofman, Shankar Siva, Tokihiro Yamamoto

Research output: Contribution to journalArticlepeer-review

Abstract

Pulmonary functional imaging has demonstrated potential to improve thoracic radiotherapy. The purpose of this study was twofold: 1) to quantify ventilation/perfusion relationships in lung cancer patients using a new functional imaging approach, gallium-68 (68Ga)-positron emission tomography/computed tomography (PET/CT); and 2) to compare ventilation/perfusion matching with diffusing capacity of the lung for carbon monoxide (DLCO). Voxel-wise correlations between ventilation and perfusion varied widely among 19 patients (range: 0.26–0.88). 68Ga-PET/CT-measured percent gas exchanging lung volume was moderately correlated with DLCO (≤0.59). Our findings suggested that 68Ga-PET/CT ventilation/perfusion imaging provided complementary information and a reasonable surrogate for gas exchange in lung cancer patients.

Original languageEnglish (US)
Pages (from-to)8-12
Number of pages5
JournalPhysics and Imaging in Radiation Oncology
Volume22
DOIs
StatePublished - Apr 2022

Keywords

  • Lung cancer
  • Lung function
  • Positron emission tomography/computed tomography (PET/CT)
  • Ventilation/perfusion

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging

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