Quantitative assessment of ventilation-perfusion relationships with gallium-68 positron emission tomography/computed tomography imaging in lung cancer patients

Zhuorui Li; Pierre Yves Le Roux; Jason Callahan; Nicholas Hardcastle; Michael S. Hofman; Shankar Siva; Tokihiro Yamamoto

doi:10.1016/j.phro.2022.03.005

Quantitative assessment of ventilation-perfusion relationships with gallium-68 positron emission tomography/computed tomography imaging in lung cancer patients

Zhuorui Li, Pierre Yves Le Roux, Jason Callahan, Nicholas Hardcastle, Michael S. Hofman, Shankar Siva, Tokihiro Yamamoto

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

Abstract

Pulmonary functional imaging has demonstrated potential to improve thoracic radiotherapy. The purpose of this study was twofold: 1) to quantify ventilation/perfusion relationships in lung cancer patients using a new functional imaging approach, gallium-68 (⁶⁸Ga)-positron emission tomography/computed tomography (PET/CT); and 2) to compare ventilation/perfusion matching with diffusing capacity of the lung for carbon monoxide (D_LCO). Voxel-wise correlations between ventilation and perfusion varied widely among 19 patients (range: 0.26–0.88). ⁶⁸Ga-PET/CT-measured percent gas exchanging lung volume was moderately correlated with D_LCO (≤0.59). Our findings suggested that ⁶⁸Ga-PET/CT ventilation/perfusion imaging provided complementary information and a reasonable surrogate for gas exchange in lung cancer patients.

Original language	English (US)
Pages (from-to)	8-12
Number of pages	5
Journal	Physics and Imaging in Radiation Oncology
Volume	22
DOIs	https://doi.org/10.1016/j.phro.2022.03.005
State	Published - Apr 2022

Keywords

Lung cancer
Lung function
Positron emission tomography/computed tomography (PET/CT)
Ventilation/perfusion

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging

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10.1016/j.phro.2022.03.005

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Quantitative assessment of ventilation-perfusion relationships with gallium-68 positron emission tomography/computed tomography imaging in lung cancer patients. / Li, Zhuorui; Le Roux, Pierre Yves; Callahan, Jason; Hardcastle, Nicholas; Hofman, Michael S.; Siva, Shankar; Yamamoto, Tokihiro.

In: Physics and Imaging in Radiation Oncology, Vol. 22, 04.2022, p. 8-12.

Research output: Contribution to journal › Article › peer-review

Li, Zhuorui ; Le Roux, Pierre Yves ; Callahan, Jason ; Hardcastle, Nicholas ; Hofman, Michael S. ; Siva, Shankar ; Yamamoto, Tokihiro. / Quantitative assessment of ventilation-perfusion relationships with gallium-68 positron emission tomography/computed tomography imaging in lung cancer patients. In: Physics and Imaging in Radiation Oncology. 2022 ; Vol. 22. pp. 8-12.

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title = "Quantitative assessment of ventilation-perfusion relationships with gallium-68 positron emission tomography/computed tomography imaging in lung cancer patients",

abstract = "Pulmonary functional imaging has demonstrated potential to improve thoracic radiotherapy. The purpose of this study was twofold: 1) to quantify ventilation/perfusion relationships in lung cancer patients using a new functional imaging approach, gallium-68 (68Ga)-positron emission tomography/computed tomography (PET/CT); and 2) to compare ventilation/perfusion matching with diffusing capacity of the lung for carbon monoxide (DLCO). Voxel-wise correlations between ventilation and perfusion varied widely among 19 patients (range: 0.26–0.88). 68Ga-PET/CT-measured percent gas exchanging lung volume was moderately correlated with DLCO (≤0.59). Our findings suggested that 68Ga-PET/CT ventilation/perfusion imaging provided complementary information and a reasonable surrogate for gas exchange in lung cancer patients.",

keywords = "Lung cancer, Lung function, Positron emission tomography/computed tomography (PET/CT), Ventilation/perfusion",

author = "Zhuorui Li and {Le Roux}, {Pierre Yves} and Jason Callahan and Nicholas Hardcastle and Hofman, {Michael S.} and Shankar Siva and Tokihiro Yamamoto",

note = "Funding Information: This study was supported by funding from the Cancer Australia Priority-driven Collaborative Cancer Research Scheme (Project No. 1060919) (Drs. Hofman and Siva). Dr. Hofman and Dr. Siva were supported by a Clinical Research Fellowship from the Peter MacCallum Foundation, and Dr. Siva by the Victorian Cancer Council Colebatch Fellowship. Publisher Copyright: {\textcopyright} 2022 The Authors",

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doi = "10.1016/j.phro.2022.03.005",

language = "English (US)",

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AU - Hardcastle, Nicholas

AU - Hofman, Michael S.

AU - Siva, Shankar

AU - Yamamoto, Tokihiro

N1 - Funding Information: This study was supported by funding from the Cancer Australia Priority-driven Collaborative Cancer Research Scheme (Project No. 1060919) (Drs. Hofman and Siva). Dr. Hofman and Dr. Siva were supported by a Clinical Research Fellowship from the Peter MacCallum Foundation, and Dr. Siva by the Victorian Cancer Council Colebatch Fellowship. Publisher Copyright: © 2022 The Authors

PY - 2022/4

Y1 - 2022/4

N2 - Pulmonary functional imaging has demonstrated potential to improve thoracic radiotherapy. The purpose of this study was twofold: 1) to quantify ventilation/perfusion relationships in lung cancer patients using a new functional imaging approach, gallium-68 (68Ga)-positron emission tomography/computed tomography (PET/CT); and 2) to compare ventilation/perfusion matching with diffusing capacity of the lung for carbon monoxide (DLCO). Voxel-wise correlations between ventilation and perfusion varied widely among 19 patients (range: 0.26–0.88). 68Ga-PET/CT-measured percent gas exchanging lung volume was moderately correlated with DLCO (≤0.59). Our findings suggested that 68Ga-PET/CT ventilation/perfusion imaging provided complementary information and a reasonable surrogate for gas exchange in lung cancer patients.

AB - Pulmonary functional imaging has demonstrated potential to improve thoracic radiotherapy. The purpose of this study was twofold: 1) to quantify ventilation/perfusion relationships in lung cancer patients using a new functional imaging approach, gallium-68 (68Ga)-positron emission tomography/computed tomography (PET/CT); and 2) to compare ventilation/perfusion matching with diffusing capacity of the lung for carbon monoxide (DLCO). Voxel-wise correlations between ventilation and perfusion varied widely among 19 patients (range: 0.26–0.88). 68Ga-PET/CT-measured percent gas exchanging lung volume was moderately correlated with DLCO (≤0.59). Our findings suggested that 68Ga-PET/CT ventilation/perfusion imaging provided complementary information and a reasonable surrogate for gas exchange in lung cancer patients.

KW - Lung cancer

KW - Lung function

KW - Positron emission tomography/computed tomography (PET/CT)

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Quantitative assessment of ventilation-perfusion relationships with gallium-68 positron emission tomography/computed tomography imaging in lung cancer patients

Abstract

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