Quantitative assessment of Cerenkov luminescence for radioguided brain tumor resection surgery

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8 Scopus citations


Cerenkov luminescence imaging (CLI) is a developing imaging modality that detects radiolabeled molecules via visible light emitted during the radioactive decay process. We used a Monte Carlo based computer simulation to quantitatively investigate CLI compared to direct detection of the ionizing radiation itself as an intraoperative imaging tool for assessment of brain tumor margins. Our brain tumor model consisted of a 1 mm spherical tumor remnant embedded up to 5 mm in depth below the surface of normal brain tissue. Tumor to background contrast ranging from 2:1 to 10:1 were considered. We quantified all decay signals (e±, gamma photon, Cerenkov photons) reaching the brain volume surface. CLI proved to be the most sensitive method for detecting the tumor volume in both imaging and non-imaging strategies as assessed by contrast-to-noise ratio and by receiver operating characteristic output of a channelized Hotelling observer.

Original languageEnglish (US)
Pages (from-to)4183-4201
Number of pages19
JournalPhysics in Medicine and Biology
Issue number10
StatePublished - Apr 28 2017


  • Cerenkov luminescence
  • Cerenkov radiation
  • glioma
  • intraoperative imaging
  • molecular imaging
  • optical imaging
  • surgical guidance

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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