Quantitative and Qualitative Evaluation of Dermal Elastin of Draught Horses with Chronic Progressive Lymphoedema

H. E V De Cock, L. Van Brantegem, Verena K Affolter, M. Oosterlinck, G. L. Ferraro, R. Ducatelle

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Chronic progressive lymphoedema (CPL) in horses, a disease of certain draught breeds, is associated with altered elastin metabolism. The characteristic lesions are seen in the skin of the lower (distal) limbs. This study was based on horses of susceptible breeds, with and without CPL, and on horses of a non-susceptible breed. Skin samples were obtained for examination from the neck (considered a non-affected region) and from the distal limb. The skin lesions were characterized histologically and the dermal elastic fibres were evaluated morphologically and quantitatively. In all horses the mean elastin concentrations were highest in the superficial dermis, gradually decreasing in the mid-dermis and deep dermis. As compared with horses of a non-susceptible breed, affected horses had increased amounts of dermal elastin in both the distal limb and neck, while non-affected horses of a susceptible breed had decreased amounts. The findings support an earlier hypothesis that CPL of horses is a generalized disease. Reduced efficiency of the elastic network in supporting the dermal lymphatics may explain the development of CPL.

Original languageEnglish (US)
Pages (from-to)132-139
Number of pages8
JournalJournal of Comparative Pathology
Volume140
Issue number2-3
DOIs
StatePublished - Feb 2009

Fingerprint

elastin
Lymphedema
Elastin
Horses
dermis
horses
Skin
limbs (animal)
breeds
Dermis
skin (animal)
neck
Neck
Extremities
horse diseases
horse breeds
Horse Diseases
skin lesions
Elastic Tissue
lesions (animal)

Keywords

  • elastin
  • horse
  • lymphoedema

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)

Cite this

Quantitative and Qualitative Evaluation of Dermal Elastin of Draught Horses with Chronic Progressive Lymphoedema. / De Cock, H. E V; Van Brantegem, L.; Affolter, Verena K; Oosterlinck, M.; Ferraro, G. L.; Ducatelle, R.

In: Journal of Comparative Pathology, Vol. 140, No. 2-3, 02.2009, p. 132-139.

Research output: Contribution to journalArticle

De Cock, H. E V ; Van Brantegem, L. ; Affolter, Verena K ; Oosterlinck, M. ; Ferraro, G. L. ; Ducatelle, R. / Quantitative and Qualitative Evaluation of Dermal Elastin of Draught Horses with Chronic Progressive Lymphoedema. In: Journal of Comparative Pathology. 2009 ; Vol. 140, No. 2-3. pp. 132-139.
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