Abstract
The level of urinary keratin was compared in patients with and without bladder cancer using the newly developed IRMAK-18. Patients with bladder cancer had higher levels of keratin (74.6 ± 146.9) than normals (2.5 ± 4.7). When the upper limit of normal was set at keratin <20 ng./ml., the test was highly specific (98%) for bladder cancer but had a sensitivity of only 46%. Adjusting to keratin <10 ng./ml. increased the sensitivity to 57% but decreased the specificity to 91%. Elevated keratins were associated with stage and grade, aneuploidy and disease history. The IRMAK-18 assay for keratin may be useful for monitoring the clinical progress of some patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 436-439 |
| Number of pages | 4 |
| Journal | Journal of Urology |
| Volume | 140 |
| Issue number | 2 |
| State | Published - 1988 |
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ASJC Scopus subject areas
- Urology
Cite this
Baker, W. C., deVere White, R. W., Rossitto, P. V., Min, B. H., & Cardiff, R. (1988). Quantitative analysis of keratin 18 in the urine of patients with bladder cancer. Journal of Urology, 140(2), 436-439.