Quantitative analysis of keratin 18 in the urine of patients with bladder cancer

W. C. Baker, Ralph W deVere White, P. V. Rossitto, B. H. Min, Robert Cardiff

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Abstract

The level of urinary keratin was compared in patients with and without bladder cancer using the newly developed IRMAK-18. Patients with bladder cancer had higher levels of keratin (74.6 ± 146.9) than normals (2.5 ± 4.7). When the upper limit of normal was set at keratin <20 ng./ml., the test was highly specific (98%) for bladder cancer but had a sensitivity of only 46%. Adjusting to keratin <10 ng./ml. increased the sensitivity to 57% but decreased the specificity to 91%. Elevated keratins were associated with stage and grade, aneuploidy and disease history. The IRMAK-18 assay for keratin may be useful for monitoring the clinical progress of some patients.

Original languageEnglish (US)
Pages (from-to)436-439
Number of pages4
JournalJournal of Urology
Volume140
Issue number2
StatePublished - 1988

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ASJC Scopus subject areas

  • Urology

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