Abstract
The level of urinary keratin was compared in patients with and without bladder cancer using the newly developed IRMAK-18. Patients with bladder cancer had higher levels of keratin (74.6 ± 146.9) than normals (2.5 ± 4.7). When the upper limit of normal was set at keratin <20 ng./ml., the test was highly specific (98%) for bladder cancer but had a sensitivity of only 46%. Adjusting to keratin <10 ng./ml. increased the sensitivity to 57% but decreased the specificity to 91%. Elevated keratins were associated with stage and grade, aneuploidy and disease history. The IRMAK-18 assay for keratin may be useful for monitoring the clinical progress of some patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 436-439 |
| Number of pages | 4 |
| Journal | Journal of Urology |
| Volume | 140 |
| Issue number | 2 |
| State | Published - 1988 |
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- Urology
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Quantitative analysis of keratin 18 in the urine of patients with bladder cancer. / Baker, W. C.; deVere White, Ralph W; Rossitto, P. V.; Min, B. H.; Cardiff, Robert.
In: Journal of Urology, Vol. 140, No. 2, 1988, p. 436-439.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Quantitative analysis of keratin 18 in the urine of patients with bladder cancer
AU - Baker, W. C.
AU - deVere White, Ralph W
AU - Rossitto, P. V.
AU - Min, B. H.
AU - Cardiff, Robert
PY - 1988
Y1 - 1988
N2 - The level of urinary keratin was compared in patients with and without bladder cancer using the newly developed IRMAK-18. Patients with bladder cancer had higher levels of keratin (74.6 ± 146.9) than normals (2.5 ± 4.7). When the upper limit of normal was set at keratin <20 ng./ml., the test was highly specific (98%) for bladder cancer but had a sensitivity of only 46%. Adjusting to keratin <10 ng./ml. increased the sensitivity to 57% but decreased the specificity to 91%. Elevated keratins were associated with stage and grade, aneuploidy and disease history. The IRMAK-18 assay for keratin may be useful for monitoring the clinical progress of some patients.
AB - The level of urinary keratin was compared in patients with and without bladder cancer using the newly developed IRMAK-18. Patients with bladder cancer had higher levels of keratin (74.6 ± 146.9) than normals (2.5 ± 4.7). When the upper limit of normal was set at keratin <20 ng./ml., the test was highly specific (98%) for bladder cancer but had a sensitivity of only 46%. Adjusting to keratin <10 ng./ml. increased the sensitivity to 57% but decreased the specificity to 91%. Elevated keratins were associated with stage and grade, aneuploidy and disease history. The IRMAK-18 assay for keratin may be useful for monitoring the clinical progress of some patients.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023801713&partnerID=8YFLogxK
M3 - Article
C2 - 2456406
AN - SCOPUS:0023801713
VL - 140
SP - 436
EP - 439
JO - Journal of Urology
JF - Journal of Urology
SN - 0022-5347
IS - 2
ER -