Quantifying cancer risk from exposures to medical imaging in the Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging (RIC) Study: research methods and cohort profile

Marilyn L. Kwan, Diana L. Miglioretti, Erin J.A. Bowles, Sheila Weinmann, Robert T. Greenlee, Natasha K. Stout, Alanna Kulchak Rahm, Susan A. Alber, Priscila Pequeno, Lisa M. Moy, Carly Stewart, Cindy Fong, Charisma L. Jenkins, Diane Kohnhorst, Casey Luce, Joanne M. Mor, Julie R. Munneke, Yolanda Prado, Glen Buth, Stephanie Y. ChengKamala A. Deosaransingh, Melanie Francisco, Matthew Lakoma, Yannica Theda Martinez, Mary Kay Theis, Emily C. Marlow, Lawrence Kushi, James R. Duncan, Wesley E. Bolch, Jason D. Pole, Rebecca Smith-Bindman

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging (RIC) Study is quantifying the association between cumulative radiation exposure from fetal and/or childhood medical imaging and subsequent cancer risk. This manuscript describes the study cohorts and research methods. Methods: The RIC Study is a longitudinal study of children in two retrospective cohorts from 6 U.S. healthcare systems and from Ontario, Canada over the period 1995–2017. The fetal-exposure cohort includes children whose mothers were enrolled in the healthcare system during their entire pregnancy and followed to age 20. The childhood-exposure cohort includes children born into the system and followed while continuously enrolled. Imaging utilization was determined using administrative data. Computed tomography (CT) parameters were collected to estimate individualized patient organ dosimetry. Organ dose libraries for average exposures were constructed for radiography, fluoroscopy, and angiography, while diagnostic radiopharmaceutical biokinetic models were applied to estimate organ doses received in nuclear medicine procedures. Cancers were ascertained from local and state/provincial cancer registry linkages. Results: The fetal-exposure cohort includes 3,474,000 children among whom 6,606 cancers (2394 leukemias) were diagnosed over 37,659,582 person-years; 0.5% had in utero exposure to CT, 4.0% radiography, 0.5% fluoroscopy, 0.04% angiography, 0.2% nuclear medicine. The childhood-exposure cohort includes 3,724,632 children in whom 6,358 cancers (2,372 leukemias) were diagnosed over 36,190,027 person-years; 5.9% were exposed to CT, 61.1% radiography, 6.0% fluoroscopy, 0.4% angiography, 1.5% nuclear medicine. Conclusion: The RIC Study is poised to be the largest study addressing risk of childhood and adolescent cancer associated with ionizing radiation from medical imaging, estimated with individualized patient organ dosimetry.

Original languageEnglish (US)
JournalCancer Causes and Control
DOIs
StateAccepted/In press - 2022

Keywords

  • Childhood cancer
  • Childhood leukemia
  • Computed tomography
  • Ionizing radiation
  • Medical imaging
  • Retrospective cohort study

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Quantifying cancer risk from exposures to medical imaging in the Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging (RIC) Study: research methods and cohort profile'. Together they form a unique fingerprint.

Cite this