Quantification of varying adhesion levels in chondrocytes using the cytodetacher

Gwendolyn Hoben, Wei Huang, Brian S. Thoma, Richard G. LeBaron, Kyriacos A. Athanasiou

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Varying adhesion levels in chondrocytes were quantified using the cytodetacher. The sensitivity of the cytodetacher was gauged by detaching live rabit chondrocytes seeded for varying amounts of time. Results validated the hypothesis that fixed cells were characterized by greater mechanical adhesiveness and interface stiffness. This study showed that the cytodetacher provided adequate resolution in measuring the mechanical adhesion properties of single cells.

Original languageEnglish (US)
Pages (from-to)703-712
Number of pages10
JournalAnnals of Biomedical Engineering
Volume30
Issue number5
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Cell adhesion
  • Cell biomechanics
  • Formalin fixation

ASJC Scopus subject areas

  • Biomedical Engineering

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  • Cite this

    Hoben, G., Huang, W., Thoma, B. S., LeBaron, R. G., & Athanasiou, K. A. (2002). Quantification of varying adhesion levels in chondrocytes using the cytodetacher. Annals of Biomedical Engineering, 30(5), 703-712. https://doi.org/10.1114/1.1484218