Quantification of left ventricular mass using cardiac magnetic resonance imaging compared with echocardiography in domestic cats

Kristin A. MacDonald, Mark D Kittleson, Tracy Reed, Richard Larson, Philip H Kass, Erik R Wisner

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The hypotheses were that cardiac magnetic resonance imaging (cMRI) would accurately determine LV mass in domestic cats and would do so more accurately than echocardiography (ECHO). ECHO was performed on seven sedated cats. LV mass was calculated using the truncated ellipse formula from a right parasternal long-axis view. T1 weighted gradient echo cMRI was acquired from anesthetized cats during multiple phases of the cardiac cycle. Short-axis images were obtained by acquiring 3 mm thick contiguous slices perpendicular to the cardiac long axis. LV mass was determined using Simpson's rule. Endocardial and epicardial borders were traced on each slice at end-systole, end-diastole, and mid-cycle and the difference in areas was myocardial area. Myocardial area was multiplied by slice thickness to calculate myocardial volume. Total (summated) myocardial volume was multiplied by myocardial density (1.05) to obtain LV mass at three measured phases of the cardiac cycle. Cats were euthanized and the LV was dissected and weighed to determine true mass. CMRI at end-systole most accurately quantified LV mass and was more accurate than echocardiography (P = 0.0078). Actual LV mass ranged from 6.5 to 10.5 g (mean = 8.5 g, SD = 1.6 g) compared with MRI LV mass at end-systole, which ranged from 6.7 to 11.1 g (mean = 8.7 g, SD = 1.7 g) and echocardiographic LV mass at end-diastole, which ranged from 5.2 to 9.1 g (mean = 7.1 g, SD = 1.8 g). Inter- and intraobserver variability for cMRI was 2%. CMRI obtained at end-systole accurately and reliably quantifies LV mass in domestic cats. It is more accurate than the echocardiographic method used in this study.

Original languageEnglish (US)
Pages (from-to)192-199
Number of pages8
JournalVeterinary Radiology and Ultrasound
Volume46
Issue number3
DOIs
StatePublished - May 2005

Fingerprint

echocardiography
magnetic resonance imaging
Systole
Echocardiography
Cats
Magnetic Resonance Imaging
cats
Diastole
Observer Variation

Keywords

  • Gradient echo sequence
  • Myocardial mass
  • Quantification
  • Simpson's rule
  • Truncated ellipse formula

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Quantification of left ventricular mass using cardiac magnetic resonance imaging compared with echocardiography in domestic cats. / MacDonald, Kristin A.; Kittleson, Mark D; Reed, Tracy; Larson, Richard; Kass, Philip H; Wisner, Erik R.

In: Veterinary Radiology and Ultrasound, Vol. 46, No. 3, 05.2005, p. 192-199.

Research output: Contribution to journalArticle

@article{5eb68eb89ca048dda3c6f30c57d9f8c9,
title = "Quantification of left ventricular mass using cardiac magnetic resonance imaging compared with echocardiography in domestic cats",
abstract = "The hypotheses were that cardiac magnetic resonance imaging (cMRI) would accurately determine LV mass in domestic cats and would do so more accurately than echocardiography (ECHO). ECHO was performed on seven sedated cats. LV mass was calculated using the truncated ellipse formula from a right parasternal long-axis view. T1 weighted gradient echo cMRI was acquired from anesthetized cats during multiple phases of the cardiac cycle. Short-axis images were obtained by acquiring 3 mm thick contiguous slices perpendicular to the cardiac long axis. LV mass was determined using Simpson's rule. Endocardial and epicardial borders were traced on each slice at end-systole, end-diastole, and mid-cycle and the difference in areas was myocardial area. Myocardial area was multiplied by slice thickness to calculate myocardial volume. Total (summated) myocardial volume was multiplied by myocardial density (1.05) to obtain LV mass at three measured phases of the cardiac cycle. Cats were euthanized and the LV was dissected and weighed to determine true mass. CMRI at end-systole most accurately quantified LV mass and was more accurate than echocardiography (P = 0.0078). Actual LV mass ranged from 6.5 to 10.5 g (mean = 8.5 g, SD = 1.6 g) compared with MRI LV mass at end-systole, which ranged from 6.7 to 11.1 g (mean = 8.7 g, SD = 1.7 g) and echocardiographic LV mass at end-diastole, which ranged from 5.2 to 9.1 g (mean = 7.1 g, SD = 1.8 g). Inter- and intraobserver variability for cMRI was 2{\%}. CMRI obtained at end-systole accurately and reliably quantifies LV mass in domestic cats. It is more accurate than the echocardiographic method used in this study.",
keywords = "Gradient echo sequence, Myocardial mass, Quantification, Simpson's rule, Truncated ellipse formula",
author = "MacDonald, {Kristin A.} and Kittleson, {Mark D} and Tracy Reed and Richard Larson and Kass, {Philip H} and Wisner, {Erik R}",
year = "2005",
month = "5",
doi = "10.1111/j.1740-8261.2005.00038.x",
language = "English (US)",
volume = "46",
pages = "192--199",
journal = "Veterinary Radiology and Ultrasound",
issn = "1058-8183",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Quantification of left ventricular mass using cardiac magnetic resonance imaging compared with echocardiography in domestic cats

AU - MacDonald, Kristin A.

AU - Kittleson, Mark D

AU - Reed, Tracy

AU - Larson, Richard

AU - Kass, Philip H

AU - Wisner, Erik R

PY - 2005/5

Y1 - 2005/5

N2 - The hypotheses were that cardiac magnetic resonance imaging (cMRI) would accurately determine LV mass in domestic cats and would do so more accurately than echocardiography (ECHO). ECHO was performed on seven sedated cats. LV mass was calculated using the truncated ellipse formula from a right parasternal long-axis view. T1 weighted gradient echo cMRI was acquired from anesthetized cats during multiple phases of the cardiac cycle. Short-axis images were obtained by acquiring 3 mm thick contiguous slices perpendicular to the cardiac long axis. LV mass was determined using Simpson's rule. Endocardial and epicardial borders were traced on each slice at end-systole, end-diastole, and mid-cycle and the difference in areas was myocardial area. Myocardial area was multiplied by slice thickness to calculate myocardial volume. Total (summated) myocardial volume was multiplied by myocardial density (1.05) to obtain LV mass at three measured phases of the cardiac cycle. Cats were euthanized and the LV was dissected and weighed to determine true mass. CMRI at end-systole most accurately quantified LV mass and was more accurate than echocardiography (P = 0.0078). Actual LV mass ranged from 6.5 to 10.5 g (mean = 8.5 g, SD = 1.6 g) compared with MRI LV mass at end-systole, which ranged from 6.7 to 11.1 g (mean = 8.7 g, SD = 1.7 g) and echocardiographic LV mass at end-diastole, which ranged from 5.2 to 9.1 g (mean = 7.1 g, SD = 1.8 g). Inter- and intraobserver variability for cMRI was 2%. CMRI obtained at end-systole accurately and reliably quantifies LV mass in domestic cats. It is more accurate than the echocardiographic method used in this study.

AB - The hypotheses were that cardiac magnetic resonance imaging (cMRI) would accurately determine LV mass in domestic cats and would do so more accurately than echocardiography (ECHO). ECHO was performed on seven sedated cats. LV mass was calculated using the truncated ellipse formula from a right parasternal long-axis view. T1 weighted gradient echo cMRI was acquired from anesthetized cats during multiple phases of the cardiac cycle. Short-axis images were obtained by acquiring 3 mm thick contiguous slices perpendicular to the cardiac long axis. LV mass was determined using Simpson's rule. Endocardial and epicardial borders were traced on each slice at end-systole, end-diastole, and mid-cycle and the difference in areas was myocardial area. Myocardial area was multiplied by slice thickness to calculate myocardial volume. Total (summated) myocardial volume was multiplied by myocardial density (1.05) to obtain LV mass at three measured phases of the cardiac cycle. Cats were euthanized and the LV was dissected and weighed to determine true mass. CMRI at end-systole most accurately quantified LV mass and was more accurate than echocardiography (P = 0.0078). Actual LV mass ranged from 6.5 to 10.5 g (mean = 8.5 g, SD = 1.6 g) compared with MRI LV mass at end-systole, which ranged from 6.7 to 11.1 g (mean = 8.7 g, SD = 1.7 g) and echocardiographic LV mass at end-diastole, which ranged from 5.2 to 9.1 g (mean = 7.1 g, SD = 1.8 g). Inter- and intraobserver variability for cMRI was 2%. CMRI obtained at end-systole accurately and reliably quantifies LV mass in domestic cats. It is more accurate than the echocardiographic method used in this study.

KW - Gradient echo sequence

KW - Myocardial mass

KW - Quantification

KW - Simpson's rule

KW - Truncated ellipse formula

UR - http://www.scopus.com/inward/record.url?scp=22444431747&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22444431747&partnerID=8YFLogxK

U2 - 10.1111/j.1740-8261.2005.00038.x

DO - 10.1111/j.1740-8261.2005.00038.x

M3 - Article

C2 - 16050275

AN - SCOPUS:22444431747

VL - 46

SP - 192

EP - 199

JO - Veterinary Radiology and Ultrasound

JF - Veterinary Radiology and Ultrasound

SN - 1058-8183

IS - 3

ER -