Abstract
OBJECTIVE. The purpose of this study is to prospectively compare hybrid and complex chemical shift-based MRI fat quantification methods against MR spectroscopy (MRS) lor the measurement of hepatic steatosis. SUBJECTS AND METHODS. Forty-two subjects (18 men and 24 women; mean ± SD age, 52.8 ± 14 years) were prospectively enrolled and imaged at 3 T with a chemical shift-based MRI sequence and a single-voxel MRS sequence, each in one breath-hold, Proton density fat fraction and rate constant (R<inf>2</inf>∗) using both single-and dual-R<inf>2</inf>∗ hybrid lilting methods, as well as proton density fat fraction and R<inf>2</inf>∗ maps using a complex lilting method, were generated. A single radiologist colocalized volumes of interest on the proton density fat fraction and R<inf>2</inf>∗ maps according to the spectroscopy measurement voxel. Agreement among the three MRI methods and the MRS proton density fat fraction values was assessed using linear regression, intraclass correlation coefficient (ICC), and Bland-Altman analysis. RESULTS. Correlation between the MRI and MRS measures of proton density fat fraction was excellent. Linear regression coefficients ranged from 0,98 to 1.01, and intercepts ranged from-1,12% to 0.49%, Agreement measured by ICC was also excellent (0.99 for all three methods). Bland-Altman analysis showed excellent agreement, with mean differences of-1.0% to 0.6% (SD, 1.3-1.6%). CONCLUSION. The described MRI-based liver proton density fat fraction measures are clinically feasible and accurate. The validation of proton density tat traction quantification methods is an important step toward wide availability and acceptance of the MRI-based measurement of proton density fat fraction as an accurate and generalizable hioinarker.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 297-306 |
| Number of pages | 10 |
| Journal | American Journal of Roentgenology |
| Volume | 204 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2015 |
| Externally published | Yes |
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Keywords
- Fat fraction
- Hepatic steatosis
- Proton density fat fraction
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Quantification of hepatic steatosis with a multistep adaptive fitting MRI approach : Prospective validation against MR spectroscopy. / Bashir, Mustafa R.; Zhong, Xiaodong; Nickel, Marcel D.; Fananapazir, Ghaneh; Kannengiesser, Stephan A R; Kiefer, Berthold; Dale, Brian M.
In: American Journal of Roentgenology, Vol. 204, No. 2, 01.02.2015, p. 297-306.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Quantification of hepatic steatosis with a multistep adaptive fitting MRI approach
T2 - Prospective validation against MR spectroscopy
AU - Bashir, Mustafa R.
AU - Zhong, Xiaodong
AU - Nickel, Marcel D.
AU - Fananapazir, Ghaneh
AU - Kannengiesser, Stephan A R
AU - Kiefer, Berthold
AU - Dale, Brian M.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - OBJECTIVE. The purpose of this study is to prospectively compare hybrid and complex chemical shift-based MRI fat quantification methods against MR spectroscopy (MRS) lor the measurement of hepatic steatosis. SUBJECTS AND METHODS. Forty-two subjects (18 men and 24 women; mean ± SD age, 52.8 ± 14 years) were prospectively enrolled and imaged at 3 T with a chemical shift-based MRI sequence and a single-voxel MRS sequence, each in one breath-hold, Proton density fat fraction and rate constant (R2∗) using both single-and dual-R2∗ hybrid lilting methods, as well as proton density fat fraction and R2∗ maps using a complex lilting method, were generated. A single radiologist colocalized volumes of interest on the proton density fat fraction and R2∗ maps according to the spectroscopy measurement voxel. Agreement among the three MRI methods and the MRS proton density fat fraction values was assessed using linear regression, intraclass correlation coefficient (ICC), and Bland-Altman analysis. RESULTS. Correlation between the MRI and MRS measures of proton density fat fraction was excellent. Linear regression coefficients ranged from 0,98 to 1.01, and intercepts ranged from-1,12% to 0.49%, Agreement measured by ICC was also excellent (0.99 for all three methods). Bland-Altman analysis showed excellent agreement, with mean differences of-1.0% to 0.6% (SD, 1.3-1.6%). CONCLUSION. The described MRI-based liver proton density fat fraction measures are clinically feasible and accurate. The validation of proton density tat traction quantification methods is an important step toward wide availability and acceptance of the MRI-based measurement of proton density fat fraction as an accurate and generalizable hioinarker.
AB - OBJECTIVE. The purpose of this study is to prospectively compare hybrid and complex chemical shift-based MRI fat quantification methods against MR spectroscopy (MRS) lor the measurement of hepatic steatosis. SUBJECTS AND METHODS. Forty-two subjects (18 men and 24 women; mean ± SD age, 52.8 ± 14 years) were prospectively enrolled and imaged at 3 T with a chemical shift-based MRI sequence and a single-voxel MRS sequence, each in one breath-hold, Proton density fat fraction and rate constant (R2∗) using both single-and dual-R2∗ hybrid lilting methods, as well as proton density fat fraction and R2∗ maps using a complex lilting method, were generated. A single radiologist colocalized volumes of interest on the proton density fat fraction and R2∗ maps according to the spectroscopy measurement voxel. Agreement among the three MRI methods and the MRS proton density fat fraction values was assessed using linear regression, intraclass correlation coefficient (ICC), and Bland-Altman analysis. RESULTS. Correlation between the MRI and MRS measures of proton density fat fraction was excellent. Linear regression coefficients ranged from 0,98 to 1.01, and intercepts ranged from-1,12% to 0.49%, Agreement measured by ICC was also excellent (0.99 for all three methods). Bland-Altman analysis showed excellent agreement, with mean differences of-1.0% to 0.6% (SD, 1.3-1.6%). CONCLUSION. The described MRI-based liver proton density fat fraction measures are clinically feasible and accurate. The validation of proton density tat traction quantification methods is an important step toward wide availability and acceptance of the MRI-based measurement of proton density fat fraction as an accurate and generalizable hioinarker.
KW - Fat fraction
KW - Hepatic steatosis
KW - Proton density fat fraction
UR - http://www.scopus.com/inward/record.url?scp=84928540723&partnerID=8YFLogxK
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U2 - 10.2214/AJR.14.12457
DO - 10.2214/AJR.14.12457
M3 - Article
VL - 204
SP - 297
EP - 306
JO - American Journal of Roentgenology
JF - American Journal of Roentgenology
SN - 0361-803X
IS - 2
ER -