Quantification of hepatic and renal cortical echogenicity in clinically normal cats

William Tod Drost, George A. Henry, James H. Meinkoth, J. Paul Woods, Terry W Lehenbauer

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objective - To quantitatively determine echogenicity of the liver and renal cortex in clinically normal cats. Animals - 17 clinically normal adult cats. Procedure - 3 ultrasonographic images of the liver and the right kidney were digitized from video output from each cat. Without changing the ultrasound machine settings, an image of a tissue-equivalent phantom was digitized. Biopsy specimens of the right renal cortex and liver were obtained for histologic examination. Mean pixel intensities within the region of interest (ROI) on hepatic, renal cortical, and tissue-equivalent phantom ultrasonographic images were determined by histogram analysis. From ultrasonographic images, mean pixel intensities for hepatic and renal cortical ROI were standardized by dividing each mean value by the mean pixel intensity from the tissue-equivalent phantom. Results - The mean (± SD) standardized hepatic echogenicity value was 1.06 ± 0.02 (95% confidence interval, 1.02 to 1.10). The mean standardized right renal cortical echogenicity value was 1.04 ± 0.02 (95% confidence interval, 1.01 to 1.08). The mean combined standardized hepatic and renal cortical echogenicity value was 1.02 ± 0.05 (95% confidence interval, 0.99 to 1.04). Conclusions and Clinical Relevance - Quantitative determination of hepatic and renal cortical echogenicity in cats is feasible, using histogram analysis, and may be useful for early detection of diffuse parenchymal disease and for serially evaluating disease progression. (Am J Vet Res 2000;61:1016-1020).

Original languageEnglish (US)
Pages (from-to)1016-1020
Number of pages5
JournalAmerican Journal of Veterinary Research
Volume61
Issue number9
StatePublished - Sep 2000
Externally publishedYes

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Cats
kidneys
cats
Kidney
liver
Liver
confidence interval
Confidence Intervals
cortex
disease course
Disease Progression
biopsy
Biopsy
tissues
animals

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Quantification of hepatic and renal cortical echogenicity in clinically normal cats. / Drost, William Tod; Henry, George A.; Meinkoth, James H.; Woods, J. Paul; Lehenbauer, Terry W.

In: American Journal of Veterinary Research, Vol. 61, No. 9, 09.2000, p. 1016-1020.

Research output: Contribution to journalArticle

Drost, William Tod ; Henry, George A. ; Meinkoth, James H. ; Woods, J. Paul ; Lehenbauer, Terry W. / Quantification of hepatic and renal cortical echogenicity in clinically normal cats. In: American Journal of Veterinary Research. 2000 ; Vol. 61, No. 9. pp. 1016-1020.
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N2 - Objective - To quantitatively determine echogenicity of the liver and renal cortex in clinically normal cats. Animals - 17 clinically normal adult cats. Procedure - 3 ultrasonographic images of the liver and the right kidney were digitized from video output from each cat. Without changing the ultrasound machine settings, an image of a tissue-equivalent phantom was digitized. Biopsy specimens of the right renal cortex and liver were obtained for histologic examination. Mean pixel intensities within the region of interest (ROI) on hepatic, renal cortical, and tissue-equivalent phantom ultrasonographic images were determined by histogram analysis. From ultrasonographic images, mean pixel intensities for hepatic and renal cortical ROI were standardized by dividing each mean value by the mean pixel intensity from the tissue-equivalent phantom. Results - The mean (± SD) standardized hepatic echogenicity value was 1.06 ± 0.02 (95% confidence interval, 1.02 to 1.10). The mean standardized right renal cortical echogenicity value was 1.04 ± 0.02 (95% confidence interval, 1.01 to 1.08). The mean combined standardized hepatic and renal cortical echogenicity value was 1.02 ± 0.05 (95% confidence interval, 0.99 to 1.04). Conclusions and Clinical Relevance - Quantitative determination of hepatic and renal cortical echogenicity in cats is feasible, using histogram analysis, and may be useful for early detection of diffuse parenchymal disease and for serially evaluating disease progression. (Am J Vet Res 2000;61:1016-1020).

AB - Objective - To quantitatively determine echogenicity of the liver and renal cortex in clinically normal cats. Animals - 17 clinically normal adult cats. Procedure - 3 ultrasonographic images of the liver and the right kidney were digitized from video output from each cat. Without changing the ultrasound machine settings, an image of a tissue-equivalent phantom was digitized. Biopsy specimens of the right renal cortex and liver were obtained for histologic examination. Mean pixel intensities within the region of interest (ROI) on hepatic, renal cortical, and tissue-equivalent phantom ultrasonographic images were determined by histogram analysis. From ultrasonographic images, mean pixel intensities for hepatic and renal cortical ROI were standardized by dividing each mean value by the mean pixel intensity from the tissue-equivalent phantom. Results - The mean (± SD) standardized hepatic echogenicity value was 1.06 ± 0.02 (95% confidence interval, 1.02 to 1.10). The mean standardized right renal cortical echogenicity value was 1.04 ± 0.02 (95% confidence interval, 1.01 to 1.08). The mean combined standardized hepatic and renal cortical echogenicity value was 1.02 ± 0.05 (95% confidence interval, 0.99 to 1.04). Conclusions and Clinical Relevance - Quantitative determination of hepatic and renal cortical echogenicity in cats is feasible, using histogram analysis, and may be useful for early detection of diffuse parenchymal disease and for serially evaluating disease progression. (Am J Vet Res 2000;61:1016-1020).

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