Quantification of cardiac fiber orientation using optical coherence tomography

Christine P. Fleming, Crystal M Ripplinger, Bryan Webb, Igor R. Efimov, Andrew M. Rollins

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Heterogeneity in cardiac tissue microstructure is a potential mechanism for the generation and maintenance of arrhythmias. Abnormal changes in fiber orientation increase the likelihood of arrhythmia. We present optical coherence tomography (OCT) as a method to image myofibers in excised intact heart preparations. Three-dimensional (3-D) image sets were gathered from the rabbit right ventricular free wall (RVFW) using a microscope-integrated OCT system. An automated algorithm for fiber orientation quantification in the plane parallel to the wall surface was developed. The algorithm was validated by comparison with manual measurements. Quantifying fiber orientation in the plane parallel to the wall surface from OCT images can be used to help understand the conduction system of the specific sample being imaged.

Original languageEnglish (US)
Article number030505
JournalJournal of Biomedical Optics
Volume13
Issue number3
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

fiber orientation
Optical tomography
Optical Coherence Tomography
Fiber reinforced materials
arrhythmia
tomography
Cardiac Arrhythmias
Three-Dimensional Imaging
rabbits
maintenance
Microscopes
microscopes
Maintenance
Tissue
Rabbits
conduction
preparation
microstructure
Microstructure

Keywords

  • biomedical optics
  • cardiac
  • image processing
  • optical coherence tomography

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Clinical Biochemistry

Cite this

Quantification of cardiac fiber orientation using optical coherence tomography. / Fleming, Christine P.; Ripplinger, Crystal M; Webb, Bryan; Efimov, Igor R.; Rollins, Andrew M.

In: Journal of Biomedical Optics, Vol. 13, No. 3, 030505, 2008.

Research output: Contribution to journalArticle

Fleming, Christine P. ; Ripplinger, Crystal M ; Webb, Bryan ; Efimov, Igor R. ; Rollins, Andrew M. / Quantification of cardiac fiber orientation using optical coherence tomography. In: Journal of Biomedical Optics. 2008 ; Vol. 13, No. 3.
@article{d21457448d7e4e168ca141be7ae9298f,
title = "Quantification of cardiac fiber orientation using optical coherence tomography",
abstract = "Heterogeneity in cardiac tissue microstructure is a potential mechanism for the generation and maintenance of arrhythmias. Abnormal changes in fiber orientation increase the likelihood of arrhythmia. We present optical coherence tomography (OCT) as a method to image myofibers in excised intact heart preparations. Three-dimensional (3-D) image sets were gathered from the rabbit right ventricular free wall (RVFW) using a microscope-integrated OCT system. An automated algorithm for fiber orientation quantification in the plane parallel to the wall surface was developed. The algorithm was validated by comparison with manual measurements. Quantifying fiber orientation in the plane parallel to the wall surface from OCT images can be used to help understand the conduction system of the specific sample being imaged.",
keywords = "biomedical optics, cardiac, image processing, optical coherence tomography",
author = "Fleming, {Christine P.} and Ripplinger, {Crystal M} and Bryan Webb and Efimov, {Igor R.} and Rollins, {Andrew M.}",
year = "2008",
doi = "10.1117/1.2937470",
language = "English (US)",
volume = "13",
journal = "Journal of Biomedical Optics",
issn = "1083-3668",
publisher = "SPIE",
number = "3",

}

TY - JOUR

T1 - Quantification of cardiac fiber orientation using optical coherence tomography

AU - Fleming, Christine P.

AU - Ripplinger, Crystal M

AU - Webb, Bryan

AU - Efimov, Igor R.

AU - Rollins, Andrew M.

PY - 2008

Y1 - 2008

N2 - Heterogeneity in cardiac tissue microstructure is a potential mechanism for the generation and maintenance of arrhythmias. Abnormal changes in fiber orientation increase the likelihood of arrhythmia. We present optical coherence tomography (OCT) as a method to image myofibers in excised intact heart preparations. Three-dimensional (3-D) image sets were gathered from the rabbit right ventricular free wall (RVFW) using a microscope-integrated OCT system. An automated algorithm for fiber orientation quantification in the plane parallel to the wall surface was developed. The algorithm was validated by comparison with manual measurements. Quantifying fiber orientation in the plane parallel to the wall surface from OCT images can be used to help understand the conduction system of the specific sample being imaged.

AB - Heterogeneity in cardiac tissue microstructure is a potential mechanism for the generation and maintenance of arrhythmias. Abnormal changes in fiber orientation increase the likelihood of arrhythmia. We present optical coherence tomography (OCT) as a method to image myofibers in excised intact heart preparations. Three-dimensional (3-D) image sets were gathered from the rabbit right ventricular free wall (RVFW) using a microscope-integrated OCT system. An automated algorithm for fiber orientation quantification in the plane parallel to the wall surface was developed. The algorithm was validated by comparison with manual measurements. Quantifying fiber orientation in the plane parallel to the wall surface from OCT images can be used to help understand the conduction system of the specific sample being imaged.

KW - biomedical optics

KW - cardiac

KW - image processing

KW - optical coherence tomography

UR - http://www.scopus.com/inward/record.url?scp=51649116021&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51649116021&partnerID=8YFLogxK

U2 - 10.1117/1.2937470

DO - 10.1117/1.2937470

M3 - Article

VL - 13

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

SN - 1083-3668

IS - 3

M1 - 030505

ER -