Quality of life in psychogenic nonepileptic seizures

Jerzy P. Szaflarski, Cynthia Hughes, Magdalena Szaflarski, David M. Ficker, William T Cahill, Maureen Li, Michael D. Privitera

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Purpose: Psychogenic nonepileptic seizures (PNESs) are events that alter or seem to alter the neurologic function and, in their appearance, resemble epileptic seizures (ESs). In patients with ESs the psychological and medical aspects of epilepsy greatly influence the health-related quality of life (HRQOL). The relation between these factors and PNESs is not well established. In this study, we compared HRQOL in patients with PNESs with that of patients with ESs. Methods: We evaluated 105 patients admitted to the Epilepsy Monitoring Unit of University Hospital between January 20, 2001, and January 20, 2002. Only patients with the definite diagnosis of ESs or PNESs were analyzed (n = 85). Patients completed an epilepsy-specific quality-of-life instrument (QOLIE-89), the Profile of Mood States (POMS), and Adverse Events Profile (AEP). We used t tests and regression analyses to contrast HRQOL in PNESs and ESs and to elucidate the main factors associated with HRQOL in patients with PNESs. Results: In our sample, 45 patients had PNESs, and 40 had ESs. The overall HRQOL and scores on 13 of 19 QOLIE-89 subscales were significantly lower (i.e., worse) in PNES than in ES patients. AEP and scores on five of six POMS subscales also were worse in PNES patients than in ES patients. PNES versus ES diagnosis, POMS depression/dejection, and AEP were significant predictors of HRQOL, jointly explaining 65% variation in HRQOL. The lower HRQOL in PNESs versus ESs was in part explained by depression and AEP. Conclusions: Patients with PNESs have a lower HRQOL and worse mood problems than do patients with ESs. This disadvantage is primarily due to depression and medication side effects, although these factors influence QOL in much the same way in PNES and ES patients. These baseline HRQOL data on patients with PNESs can be used to evaluate the effects of treatment in this patient population.

Original languageEnglish (US)
Pages (from-to)236-242
Number of pages7
JournalEpilepsia
Volume44
Issue number2
DOIs
StatePublished - Feb 1 2003
Externally publishedYes

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Seizures
Epilepsy
Quality of Life
Depression
Nervous System
Regression Analysis
Psychology

Keywords

  • Adverse Events Profile (AEP)
  • Epilepsy
  • Health-related quality of life (HRQOL)
  • Nonepileptic seizures (PNESs)
  • Profile of Mood States (POMS)
  • Psychogenic

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Szaflarski, J. P., Hughes, C., Szaflarski, M., Ficker, D. M., Cahill, W. T., Li, M., & Privitera, M. D. (2003). Quality of life in psychogenic nonepileptic seizures. Epilepsia, 44(2), 236-242. https://doi.org/10.1046/j.1528-1157.2003.35302.x

Quality of life in psychogenic nonepileptic seizures. / Szaflarski, Jerzy P.; Hughes, Cynthia; Szaflarski, Magdalena; Ficker, David M.; Cahill, William T; Li, Maureen; Privitera, Michael D.

In: Epilepsia, Vol. 44, No. 2, 01.02.2003, p. 236-242.

Research output: Contribution to journalArticle

Szaflarski, JP, Hughes, C, Szaflarski, M, Ficker, DM, Cahill, WT, Li, M & Privitera, MD 2003, 'Quality of life in psychogenic nonepileptic seizures', Epilepsia, vol. 44, no. 2, pp. 236-242. https://doi.org/10.1046/j.1528-1157.2003.35302.x
Szaflarski JP, Hughes C, Szaflarski M, Ficker DM, Cahill WT, Li M et al. Quality of life in psychogenic nonepileptic seizures. Epilepsia. 2003 Feb 1;44(2):236-242. https://doi.org/10.1046/j.1528-1157.2003.35302.x
Szaflarski, Jerzy P. ; Hughes, Cynthia ; Szaflarski, Magdalena ; Ficker, David M. ; Cahill, William T ; Li, Maureen ; Privitera, Michael D. / Quality of life in psychogenic nonepileptic seizures. In: Epilepsia. 2003 ; Vol. 44, No. 2. pp. 236-242.
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