Abstract
Although characterization of the genotype has undergone revolutionary advances as a result of the successful genome projects, the chasm between our understanding of a fully characterized gene sequence and the phenotypic repertoire of the organism is as broad and deep as it was in the pre-genomic era. There are two fundamental unsolved problems that provide the context for the challenges in relating genotype to phenotype. We address one of these and describe a generic method for constructing a system design space in which qualitatively distinct phenotypes can be identified and counted, their relative fitness analyzed and compared, and their tolerance to change measured.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3914-3922 |
| Number of pages | 9 |
| Journal | FEBS Letters |
| Volume | 583 |
| Issue number | 24 |
| DOIs | |
| State | Published - Dec 17 2009 |
Keywords
- Biochemical systems theory
- Fitness
- Phage lambda gene circuitry
- Robustness
- System design principle
- Tolerance
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Cell Biology
- Genetics
- Molecular Biology
- Structural Biology
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Cite this
Savageau, M. A., & Fasani, R. A. (2009). Qualitatively distinct phenotypes in the design space of biochemical systems. FEBS Letters, 583(24), 3914-3922. https://doi.org/10.1016/j.febslet.2009.10.073