Abstract
Although characterization of the genotype has undergone revolutionary advances as a result of the successful genome projects, the chasm between our understanding of a fully characterized gene sequence and the phenotypic repertoire of the organism is as broad and deep as it was in the pre-genomic era. There are two fundamental unsolved problems that provide the context for the challenges in relating genotype to phenotype. We address one of these and describe a generic method for constructing a system design space in which qualitatively distinct phenotypes can be identified and counted, their relative fitness analyzed and compared, and their tolerance to change measured.
Original language | English (US) |
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Pages (from-to) | 3914-3922 |
Number of pages | 9 |
Journal | FEBS Letters |
Volume | 583 |
Issue number | 24 |
DOIs | |
State | Published - Dec 17 2009 |
Keywords
- Biochemical systems theory
- Fitness
- Phage lambda gene circuitry
- Robustness
- System design principle
- Tolerance
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Cell Biology
- Genetics
- Molecular Biology
- Structural Biology