Pyrethroid pesticides as endocrine disruptors

Molecular mechanisms in vertebrates with a focus on fishes

Susanne M. Brander, Molly K. Gabler, Nicholas L. Fowler, Richard E Connon, Daniel Schlenk

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Pyrethroids are now the fourth most used group of insecticides worldwide. Employed in agriculture and in urban areas, they are detected in waterways at concentrations that are lethally and sublethally toxic to aquatic organisms. Highly lipophilic, pyrethroids accumulate in sediments and bioaccumulate in fishes. Additionally, these compounds are demonstrated to act as endocrine disrupting compounds (or EDCs) in mammals and fishes, and therefore interfere with endocrine signaling by blocking, mimicking, or synergizing endogenous hormones through direct receptor interactions, and indirectly via upstream signaling pathways. Pyrethroid metabolites have greater endocrine activity than their parent structures, and this activity is dependent on the enantiomer present, as some pyrethroids are chiral. Many EDCs studied thus far in fish have known estrogenic or antiestrogenic effects, and as such cause the inappropriate or altered expression of genes or proteins (i.e., Vtg-vitellogenin, Chg-choriogenin), often leading to physiological or reproductive effects. Additionally, these compounds can also interfere with other endocrine pathways and immune response. This review highlights studies that focus on the mechanisms of pyrethroid biotransformation and endocrine toxicity to fishes across a broad range of different pyrethroid types, and integrates literature on the in vitro and mammalian responses that inform these mechanisms.

Original languageEnglish (US)
Pages (from-to)8977-8992
Number of pages16
JournalEnvironmental Science and Technology
Volume50
Issue number17
DOIs
StatePublished - Sep 6 2016

Fingerprint

Endocrine Disruptors
Pyrethrins
endocrine disruptor
pyrethroid
Pesticides
Fish
vertebrate
fish
Aquatic organisms
Vitellogenins
Mammals
Enantiomers
Poisons
biotransformation
Insecticides
Metabolites
aquatic organism
immune response
Agriculture
hormone

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry

Cite this

Pyrethroid pesticides as endocrine disruptors : Molecular mechanisms in vertebrates with a focus on fishes. / Brander, Susanne M.; Gabler, Molly K.; Fowler, Nicholas L.; Connon, Richard E; Schlenk, Daniel.

In: Environmental Science and Technology, Vol. 50, No. 17, 06.09.2016, p. 8977-8992.

Research output: Contribution to journalArticle

Brander, Susanne M. ; Gabler, Molly K. ; Fowler, Nicholas L. ; Connon, Richard E ; Schlenk, Daniel. / Pyrethroid pesticides as endocrine disruptors : Molecular mechanisms in vertebrates with a focus on fishes. In: Environmental Science and Technology. 2016 ; Vol. 50, No. 17. pp. 8977-8992.
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