Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex

Fuzheng Guo, Yoshiko Maeda, Joyce Ma, Jie Xu, Makoto Horiuchi, Laird Miers, Flora Vaccarino, David E Pleasure

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Previous studies have shown that oligodendroglial progenitor cells (OPCs) can give rise to neurons in vitro and in perinatal cerebral cortex in vivo. We now report that OPCs in adult murine piriform cortex express low levels of doublecortin, a marker for migratory and immature neurons. Additionally, these OPCs express Sox2, a neural stem cell marker, and Pax6, a transcription factor characteristic of progenitors for cortical glutamatergic neurons. Genetic fate-mapping by means of an inducible Cre-LoxP recombination system proved that these OPCs differentiate into pyramidal glutamatergic neurons in piriform cortex. Several lines of evidence indicated that these newly formed neurons became functionally integrated into the cortical neuronal network. Our data suggest that NG2+/PDGFRα+ proteolipid protein promoter-expressing progenitors generate pyramidal glutamatergic neurons within normal adult piriform cortex.

Original languageEnglish (US)
Pages (from-to)12036-12049
Number of pages14
JournalJournal of Neuroscience
Volume30
Issue number36
DOIs
StatePublished - Sep 8 2010

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Pyramidal Cells
Stem Cells
Neurons
Proteolipids
Neural Stem Cells
Cerebral Cortex
Genetic Recombination
Transcription Factors
Piriform Cortex
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

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Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex. / Guo, Fuzheng; Maeda, Yoshiko; Ma, Joyce; Xu, Jie; Horiuchi, Makoto; Miers, Laird; Vaccarino, Flora; Pleasure, David E.

In: Journal of Neuroscience, Vol. 30, No. 36, 08.09.2010, p. 12036-12049.

Research output: Contribution to journalArticle

Guo, Fuzheng ; Maeda, Yoshiko ; Ma, Joyce ; Xu, Jie ; Horiuchi, Makoto ; Miers, Laird ; Vaccarino, Flora ; Pleasure, David E. / Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex. In: Journal of Neuroscience. 2010 ; Vol. 30, No. 36. pp. 12036-12049.
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