TY - JOUR
T1 - Pyloroplasty improves long-term gastric emptying in rats undergoing fund oplication
AU - Bustorff-Silva, Joaquim
AU - Fonkalsrud, Eric W.
AU - Perez, Carlos A.
AU - Hoh, Carl
AU - Raybould, Helen E
AU - Atkinson, James B.
PY - 2000/7
Y1 - 2000/7
N2 - Background: Conflicting reports exist regarding the permanence of improved gastric emptying (GE) after fundoplication for gastroesophageal reflux in children. Methods: Changes in gastric volume (GV) and GE of a radiolabeled mixed meal induced by a Nissen fundoplication (NF) were compared with those with a NF plus pyloroplasty (NF + P). GE was measured preoperatively, 15 and 30 days postoperation, in 24 Sprague-Dawley rats; 12 had NF alone, and 12 had NF + P. Results were expressed as percent gastric retention at 90 minutes (GR90). GV was measured at the same time periods in 20 additional rats. Results: NF rats had enhanced GE with reduction of preoperative GR90 from 37.6% to 23.7% at 15 days (P < .05); however, at 30 days the GR90 increased to 34.3%, NF + P rats had enhanced GE with reduction in GR90 from 37.2% to 20.8% at 15 days (P < .05), which persisted at 30 days (20.4%). Mean GV decreased from (1.36 mL/100 g body weight) preoperation to 0.86 at 15 days (P < .05) at 15 days in the NF group, and returned to 1.29 at 30 days, mean GV decreased from 1.36 to 0.91 at 15 days in the NF + P rats and persisted at 0.90 at 30 days. Conclusion: In the rat model, NF enhances GE transiently, whereas NF + P produces long-term enhancement of GE. Copyright (C) 2000 W.B. Saunders Company.
AB - Background: Conflicting reports exist regarding the permanence of improved gastric emptying (GE) after fundoplication for gastroesophageal reflux in children. Methods: Changes in gastric volume (GV) and GE of a radiolabeled mixed meal induced by a Nissen fundoplication (NF) were compared with those with a NF plus pyloroplasty (NF + P). GE was measured preoperatively, 15 and 30 days postoperation, in 24 Sprague-Dawley rats; 12 had NF alone, and 12 had NF + P. Results were expressed as percent gastric retention at 90 minutes (GR90). GV was measured at the same time periods in 20 additional rats. Results: NF rats had enhanced GE with reduction of preoperative GR90 from 37.6% to 23.7% at 15 days (P < .05); however, at 30 days the GR90 increased to 34.3%, NF + P rats had enhanced GE with reduction in GR90 from 37.2% to 20.8% at 15 days (P < .05), which persisted at 30 days (20.4%). Mean GV decreased from (1.36 mL/100 g body weight) preoperation to 0.86 at 15 days (P < .05) at 15 days in the NF group, and returned to 1.29 at 30 days, mean GV decreased from 1.36 to 0.91 at 15 days in the NF + P rats and persisted at 0.90 at 30 days. Conclusion: In the rat model, NF enhances GE transiently, whereas NF + P produces long-term enhancement of GE. Copyright (C) 2000 W.B. Saunders Company.
KW - Gastric emptying
KW - Gastroesophageal reflux
KW - Nissen fundoplication
KW - Pyloroplasty
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U2 - 10.1053/jpsu.2000.7832
DO - 10.1053/jpsu.2000.7832
M3 - Article
C2 - 10917302
AN - SCOPUS:0034235134
VL - 35
SP - 1087
EP - 1090
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
SN - 0022-3468
IS - 7
ER -