Pyloroplasty improves long-term gastric emptying in rats undergoing fund oplication

Joaquim Bustorff-Silva, Eric W. Fonkalsrud, Carlos A. Perez, Carl Hoh, Helen E Raybould, James B. Atkinson

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: Conflicting reports exist regarding the permanence of improved gastric emptying (GE) after fundoplication for gastroesophageal reflux in children. Methods: Changes in gastric volume (GV) and GE of a radiolabeled mixed meal induced by a Nissen fundoplication (NF) were compared with those with a NF plus pyloroplasty (NF + P). GE was measured preoperatively, 15 and 30 days postoperation, in 24 Sprague-Dawley rats; 12 had NF alone, and 12 had NF + P. Results were expressed as percent gastric retention at 90 minutes (GR90). GV was measured at the same time periods in 20 additional rats. Results: NF rats had enhanced GE with reduction of preoperative GR90 from 37.6% to 23.7% at 15 days (P < .05); however, at 30 days the GR90 increased to 34.3%, NF + P rats had enhanced GE with reduction in GR90 from 37.2% to 20.8% at 15 days (P < .05), which persisted at 30 days (20.4%). Mean GV decreased from (1.36 mL/100 g body weight) preoperation to 0.86 at 15 days (P < .05) at 15 days in the NF group, and returned to 1.29 at 30 days, mean GV decreased from 1.36 to 0.91 at 15 days in the NF + P rats and persisted at 0.90 at 30 days. Conclusion: In the rat model, NF enhances GE transiently, whereas NF + P produces long-term enhancement of GE. Copyright (C) 2000 W.B. Saunders Company.

Original languageEnglish (US)
Pages (from-to)1087-1090
Number of pages4
JournalJournal of Pediatric Surgery
Volume35
Issue number7
DOIs
StatePublished - Jul 2000
Externally publishedYes

Keywords

  • Gastric emptying
  • Gastroesophageal reflux
  • Nissen fundoplication
  • Pyloroplasty

ASJC Scopus subject areas

  • Surgery

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