Pyelonephritis in Dogs: Retrospective Study of 47 Histologically Diagnosed Cases (2005–2015)

J. Bouillon, E. Snead, J. Caswell, C. Feng, P. Hélie, Julie Denise Lemetayer

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: The clinicopathologic aspects of pyelonephritis have not been reported in companion animals. Hypothesis/Objectives: To evaluate the prevalence of pyelonephritis diagnosed in dogs in a academic referral population, describe the clinical signs and the diagnostic test results in dogs with pyelonephritis, and identify concurrent disorders in order to determine potential risk factors for pyelonephritis. Animals: Forty-seven dogs with a histopathologic diagnosis of pyelonephritis from the teaching hospitals of three Canadian veterinary colleges. Methods: Retrospective case series. Review of medical records and renal histologic sections. Results: Pyelonephritis was diagnosed in 0.4–1.3% of the cases at necropsy. Clinical signs included anorexia or inappetence (n = 27, 57%), lethargy (n = 24, 51%), vomiting (n = 17, 36%), and dehydration (n = 12, 25%). Thirty-five dogs (75%) had concomitant disease(s). Escherichia coli was the most common pathogen isolated (37%). Pyelonephritis was classified as acute (n = 12, 26%), subacute (n = 9, 19%), and chronic (n = 26, 55%) disease; and mild (n = 7, 15%), moderate (n = 11, 24%), and severe (n = 28, 61%). Fever was significantly associated with histopathologically subacute pyelonephritis (P = 0.01). Conclusions: In referral hospitals, pyelonephritis has a very low prevalence at necropsy. Nonspecific clinical presentation, concomitant diseases, and high variability in the diagnostic tests results make the antemortem diagnosis of pyelonephritis challenging. Neither the histopathologic stage nor the severity of the pyelonephritis was associated with fever, lumbar pain, or signs of a urinary tract infection (ie, lower urinary tract infection, upper urinary tract infection, or both) except for subacute pyelonephritis which was associated with fever.

Original languageEnglish (US)
Pages (from-to)249-259
Number of pages11
JournalJournal of Veterinary Internal Medicine
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Fingerprint

pyelonephritis
Pyelonephritis
retrospective studies
Retrospective Studies
Dogs
dogs
urinary tract diseases
Urinary Tract Infections
fever
Fever
Routine Diagnostic Tests
diagnostic techniques
necropsy
Referral and Consultation
Lethargy
dehydration (animal physiology)
Pets
Anorexia
vomiting
anorexia

Keywords

  • Canine
  • Complicated urinary tract infection
  • Subclinical bacteriuria

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Pyelonephritis in Dogs : Retrospective Study of 47 Histologically Diagnosed Cases (2005–2015). / Bouillon, J.; Snead, E.; Caswell, J.; Feng, C.; Hélie, P.; Lemetayer, Julie Denise.

In: Journal of Veterinary Internal Medicine, Vol. 32, No. 1, 01.01.2018, p. 249-259.

Research output: Contribution to journalArticle

Bouillon, J. ; Snead, E. ; Caswell, J. ; Feng, C. ; Hélie, P. ; Lemetayer, Julie Denise. / Pyelonephritis in Dogs : Retrospective Study of 47 Histologically Diagnosed Cases (2005–2015). In: Journal of Veterinary Internal Medicine. 2018 ; Vol. 32, No. 1. pp. 249-259.
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abstract = "Background: The clinicopathologic aspects of pyelonephritis have not been reported in companion animals. Hypothesis/Objectives: To evaluate the prevalence of pyelonephritis diagnosed in dogs in a academic referral population, describe the clinical signs and the diagnostic test results in dogs with pyelonephritis, and identify concurrent disorders in order to determine potential risk factors for pyelonephritis. Animals: Forty-seven dogs with a histopathologic diagnosis of pyelonephritis from the teaching hospitals of three Canadian veterinary colleges. Methods: Retrospective case series. Review of medical records and renal histologic sections. Results: Pyelonephritis was diagnosed in 0.4–1.3{\%} of the cases at necropsy. Clinical signs included anorexia or inappetence (n = 27, 57{\%}), lethargy (n = 24, 51{\%}), vomiting (n = 17, 36{\%}), and dehydration (n = 12, 25{\%}). Thirty-five dogs (75{\%}) had concomitant disease(s). Escherichia coli was the most common pathogen isolated (37{\%}). Pyelonephritis was classified as acute (n = 12, 26{\%}), subacute (n = 9, 19{\%}), and chronic (n = 26, 55{\%}) disease; and mild (n = 7, 15{\%}), moderate (n = 11, 24{\%}), and severe (n = 28, 61{\%}). Fever was significantly associated with histopathologically subacute pyelonephritis (P = 0.01). Conclusions: In referral hospitals, pyelonephritis has a very low prevalence at necropsy. Nonspecific clinical presentation, concomitant diseases, and high variability in the diagnostic tests results make the antemortem diagnosis of pyelonephritis challenging. Neither the histopathologic stage nor the severity of the pyelonephritis was associated with fever, lumbar pain, or signs of a urinary tract infection (ie, lower urinary tract infection, upper urinary tract infection, or both) except for subacute pyelonephritis which was associated with fever.",
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