Putative dendritic correlates of chronic traumatic encephalopathy: A preliminary quantitative Golgi exploration

Allysa Warling, Riri Uchida, Hyunsoo Shin, Coby Dodelson, Madeleine E. Garcia, N. Beckett Shea-Shumsky, Sarah Svirsky, Morgan Pothast, Hunter Kelley, Cynthia M. Schumann, Christine Brzezinski, Melissa D. Bauman, Allyson Alexander, Ann C. McKee, Thor D. Stein, Matthew Schall, Bob Jacobs

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder that is associated with repetitive head impacts. Neuropathologically, it is defined by the presence of perivascular hyperphosphorylated tau aggregates in cortical tissue (McKee et al., 2016, Acta Neuropathologica, 131, 75–86). Although many pathological and assumed clinical correlates of CTE have been well characterized, its effects on cortical dendritic arbors are still unknown. Here, we quantified dendrites and dendritic spines of supragranular pyramidal neurons in tissue from human frontal and occipital lobes, in 11 cases with (Mage = 79 ± 7 years) and 5 cases without (Mage = 76 ± 11 years) CTE. Tissue was stained with a modified rapid Golgi technique. Dendritic systems of 20 neurons per region in each brain (N = 640 neurons) were quantified using computer-assisted morphometry. One key finding was that CTE neurons exhibited increased variability and distributional changes across six of the eight dendritic system measures, presumably due to ongoing degeneration and compensatory reorganization of dendritic systems. However, despite heightened variation among CTE neurons, CTE cases exhibited lower mean values than Control cases in seven of the eight dendritic system measures. These dendritic alterations may represent a new pathological marker of CTE, and further examination of dendritic changes could contribute to both mechanistic and functional understandings of the disease.

Original languageEnglish (US)
JournalJournal of Comparative Neurology
DOIs
StateAccepted/In press - 2020
Externally publishedYes

Keywords

  • chronic traumatic encephalopathy
  • degeneration
  • dendrites
  • dysfunction
  • repetitive head impacts
  • RRID:SCR_001775

ASJC Scopus subject areas

  • Neuroscience(all)

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