TY - JOUR
T1 - Putative dendritic correlates of chronic traumatic encephalopathy
T2 - A preliminary quantitative Golgi exploration
AU - Warling, Allysa
AU - Uchida, Riri
AU - Shin, Hyunsoo
AU - Dodelson, Coby
AU - Garcia, Madeleine E.
AU - Shea-Shumsky, N. Beckett
AU - Svirsky, Sarah
AU - Pothast, Morgan
AU - Kelley, Hunter
AU - Schumann, Cynthia M.
AU - Brzezinski, Christine
AU - Bauman, Melissa D.
AU - Alexander, Allyson
AU - McKee, Ann C.
AU - Stein, Thor D.
AU - Schall, Matthew
AU - Jacobs, Bob
N1 - Publisher Copyright:
© 2020 Wiley Periodicals LLC.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder that is associated with repetitive head impacts. Neuropathologically, it is defined by the presence of perivascular hyperphosphorylated tau aggregates in cortical tissue (McKee et al., 2016, Acta Neuropathologica, 131, 75–86). Although many pathological and assumed clinical correlates of CTE have been well characterized, its effects on cortical dendritic arbors are still unknown. Here, we quantified dendrites and dendritic spines of supragranular pyramidal neurons in tissue from human frontal and occipital lobes, in 11 cases with (Mage = 79 ± 7 years) and 5 cases without (Mage = 76 ± 11 years) CTE. Tissue was stained with a modified rapid Golgi technique. Dendritic systems of 20 neurons per region in each brain (N = 640 neurons) were quantified using computer-assisted morphometry. One key finding was that CTE neurons exhibited increased variability and distributional changes across six of the eight dendritic system measures, presumably due to ongoing degeneration and compensatory reorganization of dendritic systems. However, despite heightened variation among CTE neurons, CTE cases exhibited lower mean values than Control cases in seven of the eight dendritic system measures. These dendritic alterations may represent a new pathological marker of CTE, and further examination of dendritic changes could contribute to both mechanistic and functional understandings of the disease.
AB - Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder that is associated with repetitive head impacts. Neuropathologically, it is defined by the presence of perivascular hyperphosphorylated tau aggregates in cortical tissue (McKee et al., 2016, Acta Neuropathologica, 131, 75–86). Although many pathological and assumed clinical correlates of CTE have been well characterized, its effects on cortical dendritic arbors are still unknown. Here, we quantified dendrites and dendritic spines of supragranular pyramidal neurons in tissue from human frontal and occipital lobes, in 11 cases with (Mage = 79 ± 7 years) and 5 cases without (Mage = 76 ± 11 years) CTE. Tissue was stained with a modified rapid Golgi technique. Dendritic systems of 20 neurons per region in each brain (N = 640 neurons) were quantified using computer-assisted morphometry. One key finding was that CTE neurons exhibited increased variability and distributional changes across six of the eight dendritic system measures, presumably due to ongoing degeneration and compensatory reorganization of dendritic systems. However, despite heightened variation among CTE neurons, CTE cases exhibited lower mean values than Control cases in seven of the eight dendritic system measures. These dendritic alterations may represent a new pathological marker of CTE, and further examination of dendritic changes could contribute to both mechanistic and functional understandings of the disease.
KW - chronic traumatic encephalopathy
KW - degeneration
KW - dendrites
KW - dysfunction
KW - repetitive head impacts
KW - RRID:SCR_001775
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U2 - 10.1002/cne.25022
DO - 10.1002/cne.25022
M3 - Article
C2 - 32869318
AN - SCOPUS:85091362399
JO - Journal of Comparative Neurology
JF - Journal of Comparative Neurology
SN - 0021-9967
ER -