Abstract
Equine purpura hemorrhagica (PH) is an acute, non-contagious, aseptic necrotizing vasculitis, characterized by edema and petechial or ecchymotic hemorrhage of the mucosa and subcutaneous tissue. The exact pathogenesis of PH is not fully understood at this time, but the vasculitis appears to be caused by the deposition of antigen-antibody immune complexes on blood vessel walls. Although the prevalence is unknown, PH is often associated with infection or vaccination against Streptococcus equi subsp. equi (S. equi). Purpura hemorrhagica can also occur with other infections, including equine influenza, equine viral arteritis, equine herpes virus type 1, Streptococcus equi subsp. zooepidemicus, Rhodococcus equi and Corynebacterium pseudotuberculosis. However, in some cases, the disease occurs in the absence of any known or documented infection. The mainstay treatment protocol for treating PH is aimed at reducing the inflammation associated with the blood vessel walls, removing the inciting cause, and providing supportive care.
| Original language | English (US) |
|---|---|
| Title of host publication | Equine Clinical Immunology |
| Publisher | wiley |
| Pages | 83-86 |
| Number of pages | 4 |
| ISBN (Electronic) | 9781119086512 |
| ISBN (Print) | 9781118558874 |
| DOIs | |
| State | Published - Jan 5 2016 |
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Keywords
- Antigen-antibody immune complexes
- Antigen-antibody immune complexes
- Equine purpura hemorrhagica
- Streptococcus equi
ASJC Scopus subject areas
- veterinary(all)
Cite this
Purpura Hemorrhagica. / Hunyadi, Laszlo M.; Pusterla, Nicola.
Equine Clinical Immunology. wiley, 2016. p. 83-86.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Purpura Hemorrhagica
AU - Hunyadi, Laszlo M.
AU - Pusterla, Nicola
PY - 2016/1/5
Y1 - 2016/1/5
N2 - Equine purpura hemorrhagica (PH) is an acute, non-contagious, aseptic necrotizing vasculitis, characterized by edema and petechial or ecchymotic hemorrhage of the mucosa and subcutaneous tissue. The exact pathogenesis of PH is not fully understood at this time, but the vasculitis appears to be caused by the deposition of antigen-antibody immune complexes on blood vessel walls. Although the prevalence is unknown, PH is often associated with infection or vaccination against Streptococcus equi subsp. equi (S. equi). Purpura hemorrhagica can also occur with other infections, including equine influenza, equine viral arteritis, equine herpes virus type 1, Streptococcus equi subsp. zooepidemicus, Rhodococcus equi and Corynebacterium pseudotuberculosis. However, in some cases, the disease occurs in the absence of any known or documented infection. The mainstay treatment protocol for treating PH is aimed at reducing the inflammation associated with the blood vessel walls, removing the inciting cause, and providing supportive care.
AB - Equine purpura hemorrhagica (PH) is an acute, non-contagious, aseptic necrotizing vasculitis, characterized by edema and petechial or ecchymotic hemorrhage of the mucosa and subcutaneous tissue. The exact pathogenesis of PH is not fully understood at this time, but the vasculitis appears to be caused by the deposition of antigen-antibody immune complexes on blood vessel walls. Although the prevalence is unknown, PH is often associated with infection or vaccination against Streptococcus equi subsp. equi (S. equi). Purpura hemorrhagica can also occur with other infections, including equine influenza, equine viral arteritis, equine herpes virus type 1, Streptococcus equi subsp. zooepidemicus, Rhodococcus equi and Corynebacterium pseudotuberculosis. However, in some cases, the disease occurs in the absence of any known or documented infection. The mainstay treatment protocol for treating PH is aimed at reducing the inflammation associated with the blood vessel walls, removing the inciting cause, and providing supportive care.
KW - Antigen-antibody immune complexes
KW - Antigen-antibody immune complexes
KW - Equine purpura hemorrhagica
KW - Streptococcus equi
UR - http://www.scopus.com/inward/record.url?scp=84977440690&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84977440690&partnerID=8YFLogxK
U2 - 10.1002/9781119086512.ch10
DO - 10.1002/9781119086512.ch10
M3 - Chapter
SN - 9781118558874
SP - 83
EP - 86
BT - Equine Clinical Immunology
PB - wiley
ER -