Pulmonary vascular response to nitrous oxide to newborn lambs

J. H. Eisele, Jay M Milstein, B. W. Goetzman

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The hemodynamic effects of N2O and N2O plus hypoxia were studied in six lambs (0-3 days of age) that were instrumented with pulmonary artery flow probes and catheters, as well as aortic and left artrial catheters. N2O was administered to the awake lambs through a mask in mixtures of 75% N2O:25% O2 and 75% N2O:11% O2:14% N2. Pulmonary arterial pressure and resistance increased significantly upon exposure to N2O both during normoxia and hypoxia, and nitrous oxide also significantly elevated left atrial pressure and decreased pulmonary artery blood flow during normoxia. Aortic pressure was essentially unchanged by nitrous oxide. The data indicate that in newborn lambs the pulmonary vasculature responds to N2O with vasoconstriction.

Original languageEnglish (US)
Pages (from-to)62-64
Number of pages3
JournalAnesthesia and Analgesia
Issue number1
StatePublished - 1986

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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