Pulmonary vagal reflexes and breathing pattern are not altered in elastase-induced emphysema in rats

Jim K. Mansoor, Dallas M. Hyde, Edward S Schelegle

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Abstract

The role of nonmyelinated and myelinated vagal afferents in pulmonary reflexes and breathing pattern was examined in elastase-treated emphysemic rats. Fourteen to 17 days after intratracheal instillation of 1 IU/gm of porcine pancreatic elastase or 0.5 mL of saline, elastase-treated rats had a decreased alveolar surface area to volume of parenchyma (Sv) (42.44 ± 1.7 vs. 31.51 ± 1.1 mm2/mm3), increased quasistatic compliance (QSC) (1.05 ± 0.06 vs. 1.25 ± 0.09 mL/cm H2O), functional residual capacity (FRC) (4.31 ± 0.10 vs. 5.88 ± 0.37 mL), residual volume (RV) (3.02 ± 0.14 vs. 4.27 ± 0.31 mL), and total lung capacity (TLC) (14,04 ± 0.28 vs. 15.58 ± 0.54 mL). There were no changes in the strength of the pulmonary chemoreflex, the strength of the Hering-Breuer inflation reflex, or breathing pattern before or after vagal perineural capsaicin treatment (VPCT) or vagotomy. There were, however, significant negative correlations between Sv and TLC, FRC and RV, and a near significant (p < .09) negative correlation between Sv and QSC, but no significant correlations between Sv and indices of either the pulmonary chemoreflex or Hering-Breuer inflation reflex. The results indicate that pulmonary vagal nonmyelinated and myelinated reflex activity and breathing pattern are not affected by elastase-induced emphysema in rats.

Original languageEnglish (US)
Pages (from-to)441-457
Number of pages17
JournalExperimental Lung Research
Volume23
Issue number5
StatePublished - 1997

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Keywords

  • C-fibers
  • Elastase
  • Emphysema
  • Rapid shallow breathing
  • Vagal afferents

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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