Abstract
Exercise presents a considerable stress to the pulmonary system and ventilation-perfusion (V̇A/Q̇) heterogeneity increases with exercise, affecting the efficiency of gas exchange. In particular, prolonged heavy exercise and maximal exercise are known to increase V̇A/Q̇ heterogeneity and these changes persist into recovery. We hypothesized that the spatial heterogeneity of pulmonary perfusion would be similarly elevated after prolonged exercise. To test this, athletic subjects (n = 6, V̇O2max = 61 ml·kg-1·min-1) with exercising V̇A/Q̇ heterogeneity previously characterized by the multiple inert gas elimination technique (MIGET), performed 45 min of cycle exercise at ∼70% V̇O2max. MRI arterial spin labeling measures of pulmonary perfusion were acquired pre- and postexercise (at 20, 40, 60 min post) to quantify the spatial distribution in isogravitational (coronal) and gravitationally dependent (sagittal) planes. Regional proton density measurements allowed perfusion to be normalized for density and quantified in milliliters per minute per gram. Mean lung density did not change significantly in either plane after exercise (P = 0.19). Density-normalized perfusion increased in the sagittal plane postexercise (P = <0.01) but heterogeneity did not (all P ≥ 0.18), likely because of perfusion redistribution and vascular recruitment. Density-normalized perfusion was unchanged in the coronal plane postexercise (P = 0.66), however, perfusion heterogeneity was significantly increased as measured by the relative dispersion [RD, pre 0.62(0.07), post 0.82(0.21), P < 0.0001] and geometric standard deviation [GSD, pre 1.74(0.14), post 2.30(0.56), P < 0.005]. These changes in heterogeneity were related to the exercise-induced changes of the log standard deviation of the ventilation distribution, an MIGET index of V̇A/Q̇ heterogeneity (RD R2 = 0.68, P < 0.05, GSD, R2 = 0.55, P = 0.09). These data are consistent with but not proof of interstitial pulmonary edema as the mechanism underlying exercise-induced increases in both spatial perfusion heterogeneity and V̇A/Q̇ heterogeneity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1559-1568 |
| Number of pages | 10 |
| Journal | Journal of Applied Physiology |
| Volume | 107 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 1 2009 |
| Externally published | Yes |
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Keywords
- Functional magnetic resonance imaging
- Lung density
- Ventilation-perfusion inequality
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Pulmonary perfusion heterogeneity is increased by sustained, heavy exercise in humans. / Burnham, Kevin; Arai, T. J.; Dubowitz, D. J.; Henderson, A. C.; Holverda, S.; Buxton, R. B.; Prisk, G. K.; Hopkins, S. R.
In: Journal of Applied Physiology, Vol. 107, No. 5, 01.11.2009, p. 1559-1568.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pulmonary perfusion heterogeneity is increased by sustained, heavy exercise in humans
AU - Burnham, Kevin
AU - Arai, T. J.
AU - Dubowitz, D. J.
AU - Henderson, A. C.
AU - Holverda, S.
AU - Buxton, R. B.
AU - Prisk, G. K.
AU - Hopkins, S. R.
PY - 2009/11/1
Y1 - 2009/11/1
N2 - Exercise presents a considerable stress to the pulmonary system and ventilation-perfusion (V̇A/Q̇) heterogeneity increases with exercise, affecting the efficiency of gas exchange. In particular, prolonged heavy exercise and maximal exercise are known to increase V̇A/Q̇ heterogeneity and these changes persist into recovery. We hypothesized that the spatial heterogeneity of pulmonary perfusion would be similarly elevated after prolonged exercise. To test this, athletic subjects (n = 6, V̇O2max = 61 ml·kg-1·min-1) with exercising V̇A/Q̇ heterogeneity previously characterized by the multiple inert gas elimination technique (MIGET), performed 45 min of cycle exercise at ∼70% V̇O2max. MRI arterial spin labeling measures of pulmonary perfusion were acquired pre- and postexercise (at 20, 40, 60 min post) to quantify the spatial distribution in isogravitational (coronal) and gravitationally dependent (sagittal) planes. Regional proton density measurements allowed perfusion to be normalized for density and quantified in milliliters per minute per gram. Mean lung density did not change significantly in either plane after exercise (P = 0.19). Density-normalized perfusion increased in the sagittal plane postexercise (P = <0.01) but heterogeneity did not (all P ≥ 0.18), likely because of perfusion redistribution and vascular recruitment. Density-normalized perfusion was unchanged in the coronal plane postexercise (P = 0.66), however, perfusion heterogeneity was significantly increased as measured by the relative dispersion [RD, pre 0.62(0.07), post 0.82(0.21), P < 0.0001] and geometric standard deviation [GSD, pre 1.74(0.14), post 2.30(0.56), P < 0.005]. These changes in heterogeneity were related to the exercise-induced changes of the log standard deviation of the ventilation distribution, an MIGET index of V̇A/Q̇ heterogeneity (RD R2 = 0.68, P < 0.05, GSD, R2 = 0.55, P = 0.09). These data are consistent with but not proof of interstitial pulmonary edema as the mechanism underlying exercise-induced increases in both spatial perfusion heterogeneity and V̇A/Q̇ heterogeneity.
AB - Exercise presents a considerable stress to the pulmonary system and ventilation-perfusion (V̇A/Q̇) heterogeneity increases with exercise, affecting the efficiency of gas exchange. In particular, prolonged heavy exercise and maximal exercise are known to increase V̇A/Q̇ heterogeneity and these changes persist into recovery. We hypothesized that the spatial heterogeneity of pulmonary perfusion would be similarly elevated after prolonged exercise. To test this, athletic subjects (n = 6, V̇O2max = 61 ml·kg-1·min-1) with exercising V̇A/Q̇ heterogeneity previously characterized by the multiple inert gas elimination technique (MIGET), performed 45 min of cycle exercise at ∼70% V̇O2max. MRI arterial spin labeling measures of pulmonary perfusion were acquired pre- and postexercise (at 20, 40, 60 min post) to quantify the spatial distribution in isogravitational (coronal) and gravitationally dependent (sagittal) planes. Regional proton density measurements allowed perfusion to be normalized for density and quantified in milliliters per minute per gram. Mean lung density did not change significantly in either plane after exercise (P = 0.19). Density-normalized perfusion increased in the sagittal plane postexercise (P = <0.01) but heterogeneity did not (all P ≥ 0.18), likely because of perfusion redistribution and vascular recruitment. Density-normalized perfusion was unchanged in the coronal plane postexercise (P = 0.66), however, perfusion heterogeneity was significantly increased as measured by the relative dispersion [RD, pre 0.62(0.07), post 0.82(0.21), P < 0.0001] and geometric standard deviation [GSD, pre 1.74(0.14), post 2.30(0.56), P < 0.005]. These changes in heterogeneity were related to the exercise-induced changes of the log standard deviation of the ventilation distribution, an MIGET index of V̇A/Q̇ heterogeneity (RD R2 = 0.68, P < 0.05, GSD, R2 = 0.55, P = 0.09). These data are consistent with but not proof of interstitial pulmonary edema as the mechanism underlying exercise-induced increases in both spatial perfusion heterogeneity and V̇A/Q̇ heterogeneity.
KW - Functional magnetic resonance imaging
KW - Lung density
KW - Ventilation-perfusion inequality
UR - http://www.scopus.com/inward/record.url?scp=72749126753&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=72749126753&partnerID=8YFLogxK
U2 - 10.1152/japplphysiol.00491.2009
DO - 10.1152/japplphysiol.00491.2009
M3 - Article
C2 - 19745192
AN - SCOPUS:72749126753
VL - 107
SP - 1559
EP - 1568
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 5
ER -