Pulmonary Lymphomatoid Granulomatosis in Seven Dogs (1976–1987)

Clifford R. Berry, Peter F Moore, William P. Thomas, David Sisson, Philip D. Koblik

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Seven dogs with pulmonary lymphomatoid granulomatosis were reviewed. The disease occurred in six large‐breed and one small‐breed dogs. The dogs were five to 14 years old (mean, 8.4; median, 7), and four of seven dogs were males. Three dogs had been previously treated with adulticide therapy for canine dirofilariasis. Clinical histories included a progressive respiratory disease characterized by varying degrees of cough, dyspnea, exercise intolerance, and weight loss. Thoracic radiographic features included hilar lymphadenopathy, pulmonary masses of varying sizes, and mixed pulmonary patterns of lobar consolidation with ill‐defined interstitial and alveolar pulmonary infiltrates. Cardiovascular changes compatible with chronic dirofilariasis were present in three dogs. The clinical course was usually progressive and fatal. The survival time ranged from six days to four years (mean, 12.5 mos; median, 3 mos). Gross and histologic features included mass lesions with areas of necrosis that replaced normal pulmonary architecture. Cytologically, these lesions were characterized by infiltration with pleomorphic, angioinvasive mononuclear cells that often resulted in vascular obliteration. The infiltrating cells resembled large lymphoid cells that possessed large hyperchromatic nuclei and small amounts of cytoplasm. Systemic lymphoid neoplasia with peripheral lymphadenopathy was diagnosed in two dogs. In both cases, lymph‐node cytology was similar to the cellular infiltrates found in the lungs and consistent with a diagnosis of lymphomatoid granulomatosis. These features are compared with previously reported cases of canine lymphomatoid granulomatosis and those features identified in a similar disease described in man. (Journal of Veterinary Internal Medicine 1990; 4:157–166)

Original languageEnglish (US)
Pages (from-to)157-166
Number of pages10
JournalJournal of Veterinary Internal Medicine
Volume4
Issue number3
DOIs
StatePublished - 1990

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Lymphomatoid Granulomatosis
lungs
Dogs
Lung
dogs
Dirofilariasis
dirofilariasis
lymphatic diseases
Canidae
lesions (animal)
Veterinary Medicine
adulticides
Internal Medicine
Cough
Dyspnea
cough
Blood Vessels
Cell Biology
dyspnea
Weight Loss

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Pulmonary Lymphomatoid Granulomatosis in Seven Dogs (1976–1987). / Berry, Clifford R.; Moore, Peter F; Thomas, William P.; Sisson, David; Koblik, Philip D.

In: Journal of Veterinary Internal Medicine, Vol. 4, No. 3, 1990, p. 157-166.

Research output: Contribution to journalArticle

Berry, Clifford R. ; Moore, Peter F ; Thomas, William P. ; Sisson, David ; Koblik, Philip D. / Pulmonary Lymphomatoid Granulomatosis in Seven Dogs (1976–1987). In: Journal of Veterinary Internal Medicine. 1990 ; Vol. 4, No. 3. pp. 157-166.
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