Pulmonary hypertension and right-sided heart failure in an adult llama with hepatic disease

John R. Middleton, Munashe Chigerwe, Deborah M. Fine, James R. Turk, Jimmy C. Lattimer

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Case Description - A 13-year-old llama was examined because of lethargy, inappetence, and syncope. Clinical Findings - Physical examination revealed muffled heart and lung sounds and peripheral edema. Clinicopathologic abnormalities included lymphopenia, hyperglycemic, prerenal azotemia, mild hyponatremia, mild hypoalbuminemia, and high γ-glutamyltransferase and creatine kinase activities. On ultrasonography, the liver appeared hyperechoic and ascites and pleural effusion were seen. Echocardiography revealed severe dilatation of the right atrium, right ventricle, and pulmonary artery; severe tricuspid regurgitation; and high right ventricular systolic pressure consistent with right-sided heart failure secondary to pulmonary hypertension. Treatment and Outcome - Treatment with furosemide was attempted, but because of failing health, the llama was euthanized 4 weeks later. Macronodular cirrhosis of the liver, glomerulonephritis, and intimal fibrosis and medial hypertrophy of muscular pulmonary arteries were seen on histologic examination of postmortem specimens. Clinical Relevance - Findings in this case were similar to those reported for human patients with portopulmonary hypertension secondary to hepatic cirrhosis. Pulmonary hypertension secondary to hepatic disease should be considered in the differential diagnosis of right-sided heart failure.

Original languageEnglish (US)
Pages (from-to)756-759
Number of pages4
JournalJournal of the American Veterinary Medical Association
Volume228
Issue number5
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

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New World Camelids
llamas
liver diseases
heart failure
Pulmonary Hypertension
Liver Cirrhosis
Pulmonary Artery
hypertension
liver cirrhosis
Heart Failure
pulmonary artery
lungs
Tunica Intima
Azotemia
Heart Sounds
Tricuspid Valve Insufficiency
Hypoalbuminemia
Lethargy
Lymphopenia
Hyponatremia

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Pulmonary hypertension and right-sided heart failure in an adult llama with hepatic disease. / Middleton, John R.; Chigerwe, Munashe; Fine, Deborah M.; Turk, James R.; Lattimer, Jimmy C.

In: Journal of the American Veterinary Medical Association, Vol. 228, No. 5, 01.03.2006, p. 756-759.

Research output: Contribution to journalArticle

Middleton, John R. ; Chigerwe, Munashe ; Fine, Deborah M. ; Turk, James R. ; Lattimer, Jimmy C. / Pulmonary hypertension and right-sided heart failure in an adult llama with hepatic disease. In: Journal of the American Veterinary Medical Association. 2006 ; Vol. 228, No. 5. pp. 756-759.
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