Pulmonary fine needle aspiration biopsy: Assessing the negative diagnosis

Alaa M Afify, Rosa M. Dávila

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


OBJECTIVE: To assess the significance of the 'negative for malignancy' category when applied to pulmonary transthoracic fine needle aspiration biopsy (FNAB). STUDY DESIGN: Transthoracic lung FNABs diagnosed as 'negative for malignancy' were identified from the files of Barnes-Jewish Hospital's South and North Campus over a period of five and nine years, respectively. Histologic correlation and clinical follow-up were obtained. RESULTS: Of the 1,181 lung FNABs performed during the study period, 108 cases (9%) had a negative cytologic diagnosis. Histologic correlation was available in 46 cases (43%), of which 23 cases had benign histologic findings, and 19 cases were malignant. Thirty-five of the 62 cases without histologic correlation had clinical follow-up consistent with a benign process. CONCLUSION: Based on the histologic correlation and clinical data available, the negative predictive value was 77%. Inadequate sampling was responsible for all false negative cytologic diagnoses in this series.

Original languageEnglish (US)
Pages (from-to)601-604
Number of pages4
JournalActa Cytologica
Issue number4
StatePublished - 1999
Externally publishedYes


  • Aspiration biopsy
  • Laboratory diagnosis
  • Lung neoplasms

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology
  • Histology


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