Pulmonary fibrosis after high cumulative dose nitrosourea chemotherapy in a cat

Katherine A Skorupski, A. C. Durham, L. Duda, K. U. Sørenmo

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Small to intermediate cell alimentary lymphoma was diagnosed in a cat after abdominal exploratory surgery with no prior history of pulmonary disease. Initial response to several chemotherapy regimens was poor, but a long-term remission was achieved with CCNU (lomustine) and corticosteroid therapy. After receiving a total cumulative CCNU dose of 552 mg m-2 over 12 months, an acute episode of respiratory distress occurred and the cat died. Necropsy identified severe diffuse pulmonary fibrosis and no signs of lymphoma. This is the first report of pulmonary fibrosis following high cumulative dose nitrosourea chemotherapy in a cat.

Original languageEnglish (US)
Pages (from-to)120-125
Number of pages6
JournalVeterinary and Comparative Oncology
Volume6
Issue number2
DOIs
StatePublished - 2008

Keywords

  • Cumulative toxicity
  • Fibrosis
  • Lomustine
  • Lymphoma

ASJC Scopus subject areas

  • veterinary(all)

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