Pulmonary fibrosis after high cumulative dose nitrosourea chemotherapy in a cat

Katherine A Skorupski, A. C. Durham, L. Duda, K. U. Sørenmo

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Small to intermediate cell alimentary lymphoma was diagnosed in a cat after abdominal exploratory surgery with no prior history of pulmonary disease. Initial response to several chemotherapy regimens was poor, but a long-term remission was achieved with CCNU (lomustine) and corticosteroid therapy. After receiving a total cumulative CCNU dose of 552 mg m-2 over 12 months, an acute episode of respiratory distress occurred and the cat died. Necropsy identified severe diffuse pulmonary fibrosis and no signs of lymphoma. This is the first report of pulmonary fibrosis following high cumulative dose nitrosourea chemotherapy in a cat.

Original languageEnglish (US)
Pages (from-to)120-125
Number of pages6
JournalVeterinary and Comparative Oncology
Volume6
Issue number2
DOIs
StatePublished - 2008

Fingerprint

Lomustine
Pulmonary Fibrosis
fibrosis
drug therapy
Cats
lungs
cats
lymphoma
Drug Therapy
Lymphoma
dosage
remission
adrenal cortex hormones
distress
respiratory tract diseases
Lung Diseases
necropsy
Adrenal Cortex Hormones
surgery
therapeutics

Keywords

  • Cumulative toxicity
  • Fibrosis
  • Lomustine
  • Lymphoma

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Pulmonary fibrosis after high cumulative dose nitrosourea chemotherapy in a cat. / Skorupski, Katherine A; Durham, A. C.; Duda, L.; Sørenmo, K. U.

In: Veterinary and Comparative Oncology, Vol. 6, No. 2, 2008, p. 120-125.

Research output: Contribution to journalArticle

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