Pulmonary embolism as the presenting symptom and a confounder in ACTH-secreting bronchial carcinoid

Wei Yang, David Pham, Aren T. Vierra, Sarah Azam, Dorina Gui, John C. Yoon

Research output: Contribution to journalArticle

Abstract

Ectopic ACTH-secreting pulmonary neuroendocrine tumors are rare and account for less than 5% of endogenous Cushing’s syndrome cases. We describe an unusual case of metastatic bronchial carcinoid tumor in a young woman presenting with unprovoked pulmonary emboli, which initially prevented the detection of the primary tumor on imaging. The source of ectopic ACTH was ultimately localized by a Gallium-DOTATATE scan, which demonstrated increased tracer uptake in a right middle lobe lung nodule and multiple liver nodules. The histological diagnosis was established based on a core biopsy of a hepatic lesion and the patient was started on a glucocorticoid receptor antagonist and a somatostatin analog. This case illustrates that hypercogulability can further aggravate the diagnostic challenges in ectopic ACTH syndrome. We discuss the literature on the current diagnosis and management strategies for ectopic ACTH syndrome.

Original languageEnglish (US)
Article number19-0033
JournalEndocrinology, Diabetes and Metabolism Case Reports
Volume2019
Issue number1
DOIs
StatePublished - Jan 2019

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Carcinoid Tumor
Ectopic ACTH Syndrome
Pulmonary Embolism
Adrenocorticotropic Hormone
Lung
Gallium
Neuroendocrine Tumors
Cushing Syndrome
Liver
Glucocorticoid Receptors
Somatostatin
Embolism
Biopsy
Neoplasms

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Pulmonary embolism as the presenting symptom and a confounder in ACTH-secreting bronchial carcinoid. / Yang, Wei; Pham, David; Vierra, Aren T.; Azam, Sarah; Gui, Dorina; Yoon, John C.

In: Endocrinology, Diabetes and Metabolism Case Reports, Vol. 2019, No. 1, 19-0033, 01.2019.

Research output: Contribution to journalArticle

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