Pulmonary aspergillosis

George Richard Thompson, Thomas F. Patterson

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

As the population of patients with prolonged neutropenia, those receiving hematopoietic stem cell transplantation or lung transplantation, or those with human immunodeficiency virus or acquired immunodeficiency syndrome continues to increase, the rising incidence of pulmonary aspergillosis is unlikely to diminish. Aspergillus species are ubiquitous in nature, have no geographic predilection, and the spectrum of disease they cause is myriad, ranging from noninvasive disease with colonization to disseminated disease with an associated high mortality rate. The extent of disease is thus largely responsible for both the choice and the duration of antifungal therapy. Recent years have seen an expansion of antifungal agents, with efficacy against Aspergillus requiring an understanding of the full spectrum of disease for them to be used appropriately. Diagnosis is often difficult because existing tests lack desired sensitivity or specificity.

Original languageEnglish (US)
Pages (from-to)103-110
Number of pages8
JournalSeminars in Respiratory and Critical Care Medicine
Volume29
Issue number2
DOIs
StatePublished - Apr 2008
Externally publishedYes

Fingerprint

Pulmonary Aspergillosis
Aspergillus
Lung Transplantation
Antifungal Agents
Hematopoietic Stem Cell Transplantation
Neutropenia
Acquired Immunodeficiency Syndrome
HIV
Sensitivity and Specificity
Mortality
Incidence
Population

Keywords

  • Aspergillus fumigatus
  • Pulmonary aspergillosis
  • Voriconazole

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Critical Care

Cite this

Pulmonary aspergillosis. / Thompson, George Richard; Patterson, Thomas F.

In: Seminars in Respiratory and Critical Care Medicine, Vol. 29, No. 2, 04.2008, p. 103-110.

Research output: Contribution to journalArticle

Thompson, George Richard ; Patterson, Thomas F. / Pulmonary aspergillosis. In: Seminars in Respiratory and Critical Care Medicine. 2008 ; Vol. 29, No. 2. pp. 103-110.
@article{cb17038be0a044f88211fe8e4f490b8b,
title = "Pulmonary aspergillosis",
abstract = "As the population of patients with prolonged neutropenia, those receiving hematopoietic stem cell transplantation or lung transplantation, or those with human immunodeficiency virus or acquired immunodeficiency syndrome continues to increase, the rising incidence of pulmonary aspergillosis is unlikely to diminish. Aspergillus species are ubiquitous in nature, have no geographic predilection, and the spectrum of disease they cause is myriad, ranging from noninvasive disease with colonization to disseminated disease with an associated high mortality rate. The extent of disease is thus largely responsible for both the choice and the duration of antifungal therapy. Recent years have seen an expansion of antifungal agents, with efficacy against Aspergillus requiring an understanding of the full spectrum of disease for them to be used appropriately. Diagnosis is often difficult because existing tests lack desired sensitivity or specificity.",
keywords = "Aspergillus fumigatus, Pulmonary aspergillosis, Voriconazole",
author = "Thompson, {George Richard} and Patterson, {Thomas F.}",
year = "2008",
month = "4",
doi = "10.1055/s-2008-1063849",
language = "English (US)",
volume = "29",
pages = "103--110",
journal = "Seminars in Respiratory and Critical Care Medicine",
issn = "1069-3424",
publisher = "Thieme Medical Publishers",
number = "2",

}

TY - JOUR

T1 - Pulmonary aspergillosis

AU - Thompson, George Richard

AU - Patterson, Thomas F.

PY - 2008/4

Y1 - 2008/4

N2 - As the population of patients with prolonged neutropenia, those receiving hematopoietic stem cell transplantation or lung transplantation, or those with human immunodeficiency virus or acquired immunodeficiency syndrome continues to increase, the rising incidence of pulmonary aspergillosis is unlikely to diminish. Aspergillus species are ubiquitous in nature, have no geographic predilection, and the spectrum of disease they cause is myriad, ranging from noninvasive disease with colonization to disseminated disease with an associated high mortality rate. The extent of disease is thus largely responsible for both the choice and the duration of antifungal therapy. Recent years have seen an expansion of antifungal agents, with efficacy against Aspergillus requiring an understanding of the full spectrum of disease for them to be used appropriately. Diagnosis is often difficult because existing tests lack desired sensitivity or specificity.

AB - As the population of patients with prolonged neutropenia, those receiving hematopoietic stem cell transplantation or lung transplantation, or those with human immunodeficiency virus or acquired immunodeficiency syndrome continues to increase, the rising incidence of pulmonary aspergillosis is unlikely to diminish. Aspergillus species are ubiquitous in nature, have no geographic predilection, and the spectrum of disease they cause is myriad, ranging from noninvasive disease with colonization to disseminated disease with an associated high mortality rate. The extent of disease is thus largely responsible for both the choice and the duration of antifungal therapy. Recent years have seen an expansion of antifungal agents, with efficacy against Aspergillus requiring an understanding of the full spectrum of disease for them to be used appropriately. Diagnosis is often difficult because existing tests lack desired sensitivity or specificity.

KW - Aspergillus fumigatus

KW - Pulmonary aspergillosis

KW - Voriconazole

UR - http://www.scopus.com/inward/record.url?scp=41149137805&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41149137805&partnerID=8YFLogxK

U2 - 10.1055/s-2008-1063849

DO - 10.1055/s-2008-1063849

M3 - Article

C2 - 18365992

AN - SCOPUS:41149137805

VL - 29

SP - 103

EP - 110

JO - Seminars in Respiratory and Critical Care Medicine

JF - Seminars in Respiratory and Critical Care Medicine

SN - 1069-3424

IS - 2

ER -