Abstract
Rats are widely used for studies of pulmonary toxicology and lung disease. Several studies suggest nominal geometric parameters describing the architecture of the rat airway. However, intersubject variance has never been reported due to the huge effort and time to take these manual measurements. In this study, we present statistics of the branching pattern of six healthy male Sprague Dawley rats by automatically analyzing computed tomography images of silicon casts of their airways. Details of branching characteristics and also intersubject variance are presented. In addition, this study shows that mean and standard deviation of many geometric parameters insufficiently represent pulmonary architecture because some, such as diameter-asymmetry, are not normally distributed. Detailed statistics including inter-and intrasubject variance and distribution of the geometric parameters will aid in constructing more realistic airway models for particle transport and studies of normal and abnormal respiratory physiology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 916-926 |
| Number of pages | 11 |
| Journal | Anatomical Record |
| Volume | 291 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2008 |
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Keywords
- CT image
- Geometric parameter distribution
- Pulmonary architecture
- Sprague Dawley rats
ASJC Scopus subject areas
- Anatomy
- Histology
- Ecology, Evolution, Behavior and Systematics
- Biotechnology
- Medicine(all)
Cite this
Pulmonary architecture in the conducting regions of six rats. / Lee, Dongyoub; Fanucchi, Michelle V.; Plopper, Charles; Fung, Jennifer; Wexler, Anthony S.
In: Anatomical Record, Vol. 291, No. 8, 2008, p. 916-926.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pulmonary architecture in the conducting regions of six rats
AU - Lee, Dongyoub
AU - Fanucchi, Michelle V.
AU - Plopper, Charles
AU - Fung, Jennifer
AU - Wexler, Anthony S.
PY - 2008
Y1 - 2008
N2 - Rats are widely used for studies of pulmonary toxicology and lung disease. Several studies suggest nominal geometric parameters describing the architecture of the rat airway. However, intersubject variance has never been reported due to the huge effort and time to take these manual measurements. In this study, we present statistics of the branching pattern of six healthy male Sprague Dawley rats by automatically analyzing computed tomography images of silicon casts of their airways. Details of branching characteristics and also intersubject variance are presented. In addition, this study shows that mean and standard deviation of many geometric parameters insufficiently represent pulmonary architecture because some, such as diameter-asymmetry, are not normally distributed. Detailed statistics including inter-and intrasubject variance and distribution of the geometric parameters will aid in constructing more realistic airway models for particle transport and studies of normal and abnormal respiratory physiology.
AB - Rats are widely used for studies of pulmonary toxicology and lung disease. Several studies suggest nominal geometric parameters describing the architecture of the rat airway. However, intersubject variance has never been reported due to the huge effort and time to take these manual measurements. In this study, we present statistics of the branching pattern of six healthy male Sprague Dawley rats by automatically analyzing computed tomography images of silicon casts of their airways. Details of branching characteristics and also intersubject variance are presented. In addition, this study shows that mean and standard deviation of many geometric parameters insufficiently represent pulmonary architecture because some, such as diameter-asymmetry, are not normally distributed. Detailed statistics including inter-and intrasubject variance and distribution of the geometric parameters will aid in constructing more realistic airway models for particle transport and studies of normal and abnormal respiratory physiology.
KW - CT image
KW - Geometric parameter distribution
KW - Pulmonary architecture
KW - Sprague Dawley rats
UR - http://www.scopus.com/inward/record.url?scp=52049122890&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=52049122890&partnerID=8YFLogxK
U2 - 10.1002/ar.20726
DO - 10.1002/ar.20726
M3 - Article
C2 - 18561195
AN - SCOPUS:52049122890
VL - 291
SP - 916
EP - 926
JO - Anatomical Record
JF - Anatomical Record
SN - 1932-8486
IS - 8
ER -