Pulmonary architecture in the conducting regions of six rats

Dongyoub Lee, Michelle V. Fanucchi, Charles Plopper, Jennifer Fung, Anthony S. Wexler

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Rats are widely used for studies of pulmonary toxicology and lung disease. Several studies suggest nominal geometric parameters describing the architecture of the rat airway. However, intersubject variance has never been reported due to the huge effort and time to take these manual measurements. In this study, we present statistics of the branching pattern of six healthy male Sprague Dawley rats by automatically analyzing computed tomography images of silicon casts of their airways. Details of branching characteristics and also intersubject variance are presented. In addition, this study shows that mean and standard deviation of many geometric parameters insufficiently represent pulmonary architecture because some, such as diameter-asymmetry, are not normally distributed. Detailed statistics including inter-and intrasubject variance and distribution of the geometric parameters will aid in constructing more realistic airway models for particle transport and studies of normal and abnormal respiratory physiology.

Original languageEnglish (US)
Pages (from-to)916-926
Number of pages11
JournalAnatomical Record
Volume291
Issue number8
DOIs
StatePublished - 2008

Fingerprint

Lung Diseases
Respiratory Physiological Phenomena
lungs
Lung
branching
rats
Silicon
statistics
respiratory physiology
Toxicology
Sprague Dawley Rats
Tomography
toxicology
silicon
computed tomography
respiratory tract diseases
tomography
physiology
asymmetry
parameter

Keywords

  • CT image
  • Geometric parameter distribution
  • Pulmonary architecture
  • Sprague Dawley rats

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Ecology, Evolution, Behavior and Systematics
  • Biotechnology
  • Medicine(all)

Cite this

Pulmonary architecture in the conducting regions of six rats. / Lee, Dongyoub; Fanucchi, Michelle V.; Plopper, Charles; Fung, Jennifer; Wexler, Anthony S.

In: Anatomical Record, Vol. 291, No. 8, 2008, p. 916-926.

Research output: Contribution to journalArticle

Lee, D, Fanucchi, MV, Plopper, C, Fung, J & Wexler, AS 2008, 'Pulmonary architecture in the conducting regions of six rats', Anatomical Record, vol. 291, no. 8, pp. 916-926. https://doi.org/10.1002/ar.20726
Lee, Dongyoub ; Fanucchi, Michelle V. ; Plopper, Charles ; Fung, Jennifer ; Wexler, Anthony S. / Pulmonary architecture in the conducting regions of six rats. In: Anatomical Record. 2008 ; Vol. 291, No. 8. pp. 916-926.
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