Abstract
Coagulation changes and changes in pulmonary extravasation of albumin were measured in 132 rats: (1) with and without severe hindlimb tourniquet shock; and (2) with and without heparinization. The rats were divided into four groups: (1) nonheparinized controls; (2) nonheparinized rats with hindlimb tourniquet shock; (3) heparinized controls; and (4) heparinized rats with hindlimb tourniquet shock. In the nonheparinized rats with hindlimb shock, platelet count, Factor VIII, Factor I, prothrombin and proconvertin and plasminogen decreased, and pulmonary extravasation of albumin increased. In contrast, in the heparinized rats with hindlimb shock, only a decrease in platelets was evident. These findings suggest that severe tourniquet shock leads to intravascular coagulation with microembolization to the lungs. This would cause increased pulmonary capillary permeability or altered pulmonary microvascular forces, which account for the increased pulmonary extravasation of albumin. This extravasation is capable of producing the interstitial pulmonary edema, which is one of the changes which characterize the "shock lung syndrome.".
| Original language | English (US) |
|---|---|
| Pages (from-to) | 65-70 |
| Number of pages | 6 |
| Journal | Journal of Surgical Research |
| Volume | 19 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
Cite this
Pulmonary and coagulation changes in tourniquet shock. / Robinson, A. Jean; Holcroft, James W; Olcott IV, Cornelius; Blaisdell, F. William.
In: Journal of Surgical Research, Vol. 19, No. 1, 1975, p. 65-70.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pulmonary and coagulation changes in tourniquet shock
AU - Robinson, A. Jean
AU - Holcroft, James W
AU - Olcott IV, Cornelius
AU - Blaisdell, F. William
PY - 1975
Y1 - 1975
N2 - Coagulation changes and changes in pulmonary extravasation of albumin were measured in 132 rats: (1) with and without severe hindlimb tourniquet shock; and (2) with and without heparinization. The rats were divided into four groups: (1) nonheparinized controls; (2) nonheparinized rats with hindlimb tourniquet shock; (3) heparinized controls; and (4) heparinized rats with hindlimb tourniquet shock. In the nonheparinized rats with hindlimb shock, platelet count, Factor VIII, Factor I, prothrombin and proconvertin and plasminogen decreased, and pulmonary extravasation of albumin increased. In contrast, in the heparinized rats with hindlimb shock, only a decrease in platelets was evident. These findings suggest that severe tourniquet shock leads to intravascular coagulation with microembolization to the lungs. This would cause increased pulmonary capillary permeability or altered pulmonary microvascular forces, which account for the increased pulmonary extravasation of albumin. This extravasation is capable of producing the interstitial pulmonary edema, which is one of the changes which characterize the "shock lung syndrome.".
AB - Coagulation changes and changes in pulmonary extravasation of albumin were measured in 132 rats: (1) with and without severe hindlimb tourniquet shock; and (2) with and without heparinization. The rats were divided into four groups: (1) nonheparinized controls; (2) nonheparinized rats with hindlimb tourniquet shock; (3) heparinized controls; and (4) heparinized rats with hindlimb tourniquet shock. In the nonheparinized rats with hindlimb shock, platelet count, Factor VIII, Factor I, prothrombin and proconvertin and plasminogen decreased, and pulmonary extravasation of albumin increased. In contrast, in the heparinized rats with hindlimb shock, only a decrease in platelets was evident. These findings suggest that severe tourniquet shock leads to intravascular coagulation with microembolization to the lungs. This would cause increased pulmonary capillary permeability or altered pulmonary microvascular forces, which account for the increased pulmonary extravasation of albumin. This extravasation is capable of producing the interstitial pulmonary edema, which is one of the changes which characterize the "shock lung syndrome.".
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U2 - 10.1016/0022-4804(75)90041-4
DO - 10.1016/0022-4804(75)90041-4
M3 - Article
C2 - 1142765
AN - SCOPUS:0016690313
VL - 19
SP - 65
EP - 70
JO - Journal of Surgical Research
JF - Journal of Surgical Research
SN - 0022-4804
IS - 1
ER -