Pulmonary and coagulation changes in tourniquet shock

A. Jean Robinson, James W Holcroft, Cornelius Olcott IV, F. William Blaisdell

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Coagulation changes and changes in pulmonary extravasation of albumin were measured in 132 rats: (1) with and without severe hindlimb tourniquet shock; and (2) with and without heparinization. The rats were divided into four groups: (1) nonheparinized controls; (2) nonheparinized rats with hindlimb tourniquet shock; (3) heparinized controls; and (4) heparinized rats with hindlimb tourniquet shock. In the nonheparinized rats with hindlimb shock, platelet count, Factor VIII, Factor I, prothrombin and proconvertin and plasminogen decreased, and pulmonary extravasation of albumin increased. In contrast, in the heparinized rats with hindlimb shock, only a decrease in platelets was evident. These findings suggest that severe tourniquet shock leads to intravascular coagulation with microembolization to the lungs. This would cause increased pulmonary capillary permeability or altered pulmonary microvascular forces, which account for the increased pulmonary extravasation of albumin. This extravasation is capable of producing the interstitial pulmonary edema, which is one of the changes which characterize the "shock lung syndrome.".

Original languageEnglish (US)
Pages (from-to)65-70
Number of pages6
JournalJournal of Surgical Research
Volume19
Issue number1
DOIs
StatePublished - 1975
Externally publishedYes

Fingerprint

Tourniquets
Hindlimb
Shock
Lung
Albumins
Factor VII
Plasminogen
Adult Respiratory Distress Syndrome
Factor VIII
Capillary Permeability
Prothrombin
Pulmonary Edema
Platelet Count
Fibrinogen
Blood Platelets

ASJC Scopus subject areas

  • Surgery

Cite this

Pulmonary and coagulation changes in tourniquet shock. / Robinson, A. Jean; Holcroft, James W; Olcott IV, Cornelius; Blaisdell, F. William.

In: Journal of Surgical Research, Vol. 19, No. 1, 1975, p. 65-70.

Research output: Contribution to journalArticle

Robinson, A. Jean ; Holcroft, James W ; Olcott IV, Cornelius ; Blaisdell, F. William. / Pulmonary and coagulation changes in tourniquet shock. In: Journal of Surgical Research. 1975 ; Vol. 19, No. 1. pp. 65-70.
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