Pulmonary alveolar macrophage: Demonstration of Na+ - K+, Mg++ ATPase activity

Mohammad G. Mustafa, Ali B. Ibrahim, Chinh T. Le, Carroll E Cross

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Abstract

Pulmonary alveolar macrophages (PAMs) were isolated from the lungs of rabbits and sheep. The intact cells manifested an ATPase activity which was dependent upon the presence of Mg++ and was further stimulated upon addition of Na+ and K+. Cardiac glycosides strongly inhibited the system. The activity was somewhat sensitive to azide, Ca++ and Cd++ but insensitive to dinitrophenol and oligomycin. It is possible that environmental agents may influence this PAM Na+ - K+, Mg++ ATPase.

Original languageEnglish (US)
Pages (from-to)1343-1351
Number of pages9
JournalLife Sciences
Volume8
Issue number24 PART 2
StatePublished - Dec 15 1969

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ASJC Scopus subject areas

  • Pharmacology

Cite this

Mustafa, M. G., Ibrahim, A. B., Le, C. T., & Cross, C. E. (1969). Pulmonary alveolar macrophage: Demonstration of Na+ - K+, Mg++ ATPase activity. Life Sciences, 8(24 PART 2), 1343-1351.