Pulmonary alveolar macrophage: Demonstration of Na+ - K+, Mg++ ATPase activity

Mohammad G. Mustafa, Ali B. Ibrahim, Chinh T. Le, Carroll E Cross

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Pulmonary alveolar macrophages (PAMs) were isolated from the lungs of rabbits and sheep. The intact cells manifested an ATPase activity which was dependent upon the presence of Mg++ and was further stimulated upon addition of Na+ and K+. Cardiac glycosides strongly inhibited the system. The activity was somewhat sensitive to azide, Ca++ and Cd++ but insensitive to dinitrophenol and oligomycin. It is possible that environmental agents may influence this PAM Na+ - K+, Mg++ ATPase.

Original languageEnglish (US)
Pages (from-to)1343-1351
Number of pages9
JournalLife Sciences
Issue number24 PART 2
StatePublished - Dec 15 1969

ASJC Scopus subject areas

  • Pharmacology


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