Research output: Chapter in Book/Report/Conference proceedingChapter


Normal puberty is controlled by the higher centers of the central nervous system which regulate the activity of the hypothalamic-pituitary axis, which in turn stimulates the gonads to secrete sex steroids which bring about the physical changes of puberty. This physiology originates during the fetal stage and ends in senescence. Thus puberty represents one stage in the progression to reproductive maturity. The development of gonadotropin-releasing hormone agonists for delaying pubertal development in transgender youth was based on the normal physiology of the hypothalamic-pituitary-gonadal axis. This chapter outlines this basic control of the onset of puberty and physical changes of puberty, and briefly mentions abnormalities of puberty that may develop with a disturbance in the normal physiology.

Original languageEnglish (US)
Title of host publicationPubertal Suppression in Transgender Youth
Number of pages12
ISBN (Electronic)9780323569637
StatePublished - Jan 1 2018
Externally publishedYes


  • Adrenarche
  • Gonadarche
  • Hypergonadotropic hypogonadism
  • Hypogonadotropic hypogonadism
  • Hypothalamic pituitary gonadal axis
  • Juvenile pause
  • Menarche
  • Mini puberty of infancy
  • Precocious puberty
  • Sexual maturation stages (tanner staging)
  • Thelarche

ASJC Scopus subject areas

  • Medicine(all)


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