Pubertal girls only partially adapt to low dietary calcium intakes

Steven A. Abrams, Ian J. Griffin, Penni D. Hicks, Sheila K. Gunn

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

We evaluated the effects of low calcium in the diets of young adolescent girls. We measured calcium absorption and excretion using stable isotopes. We found partial adaptation to low intakes but a persistent large deficit relative to recommended intakes. Low calcium intakes pose a substantial risk of inadequate calcium retention. Introduction: A substantial number of adolescent girls in the United States have habitual calcium intakes <500 mg/day (about 40% of the current recommended intake). The ability to adapt to these very low intakes by increasing calcium absorption and decreasing calcium excretion is not known. We sought to determine the effects of recommended (REC-Ca) versus very low (LO-Ca) calcium intakes on calcium absorption and excretion in white and black girls. Materials and Methods: Pubertal, but premenarcheal girls, were adapted to low or recommended calcium intakes for at least 2 weeks before each study. Calcium absorption (n = 51) and endogenous fecal calcium excretion (n = 36 of the 51) were determined by dual-tracer stable isotope studies. Subjects were then switched to the other diet for at least 6 weeks, and the study was repeated. Results: Calcium intake was 389 ± 10 mg/day on LO-Ca and 1259 ± 35 mg/day on REC-Ca diets. Fractional absorption increased from 44.9 ± 1.9% on REC-Ca to 63.4 ± 1.7% on LO-Ca (p < 0.01), but the net calcium absorption remained less than one-half the value on LO-Ca as on REC-Ca. Despite decreases in both endogenous fecal calcium excretion and urinary calcium excretion, net calcium balance was much lower on LO-Ca compared with REC-Cal (131 ± 14 versus 349 ± 32 mg/day, respectively; p < 0.001). We found significantly lower urinary calcium excretion but not calcium absorption in black girls compared with white girls. Conclusions: Very low calcium intakes are only partially adapted to by increased absorption and decreased excretion. Very low calcium intakes place both white and black pubertal girls at substantial risk for inadequate calcium retention.

Original languageEnglish (US)
Pages (from-to)759-763
Number of pages5
JournalJournal of Bone and Mineral Research
Volume19
Issue number5
DOIs
StatePublished - May 2004
Externally publishedYes

Fingerprint

Dietary Calcium
Calcium
Diet
Isotopes

Keywords

  • Adolescents
  • Calcium absorption
  • Puberty
  • Stable isotopes
  • Urinary calcium

ASJC Scopus subject areas

  • Surgery

Cite this

Pubertal girls only partially adapt to low dietary calcium intakes. / Abrams, Steven A.; Griffin, Ian J.; Hicks, Penni D.; Gunn, Sheila K.

In: Journal of Bone and Mineral Research, Vol. 19, No. 5, 05.2004, p. 759-763.

Research output: Contribution to journalArticle

Abrams, Steven A. ; Griffin, Ian J. ; Hicks, Penni D. ; Gunn, Sheila K. / Pubertal girls only partially adapt to low dietary calcium intakes. In: Journal of Bone and Mineral Research. 2004 ; Vol. 19, No. 5. pp. 759-763.
@article{89de93ceaf5740fdba2e545334bbe743,
title = "Pubertal girls only partially adapt to low dietary calcium intakes",
abstract = "We evaluated the effects of low calcium in the diets of young adolescent girls. We measured calcium absorption and excretion using stable isotopes. We found partial adaptation to low intakes but a persistent large deficit relative to recommended intakes. Low calcium intakes pose a substantial risk of inadequate calcium retention. Introduction: A substantial number of adolescent girls in the United States have habitual calcium intakes <500 mg/day (about 40{\%} of the current recommended intake). The ability to adapt to these very low intakes by increasing calcium absorption and decreasing calcium excretion is not known. We sought to determine the effects of recommended (REC-Ca) versus very low (LO-Ca) calcium intakes on calcium absorption and excretion in white and black girls. Materials and Methods: Pubertal, but premenarcheal girls, were adapted to low or recommended calcium intakes for at least 2 weeks before each study. Calcium absorption (n = 51) and endogenous fecal calcium excretion (n = 36 of the 51) were determined by dual-tracer stable isotope studies. Subjects were then switched to the other diet for at least 6 weeks, and the study was repeated. Results: Calcium intake was 389 ± 10 mg/day on LO-Ca and 1259 ± 35 mg/day on REC-Ca diets. Fractional absorption increased from 44.9 ± 1.9{\%} on REC-Ca to 63.4 ± 1.7{\%} on LO-Ca (p < 0.01), but the net calcium absorption remained less than one-half the value on LO-Ca as on REC-Ca. Despite decreases in both endogenous fecal calcium excretion and urinary calcium excretion, net calcium balance was much lower on LO-Ca compared with REC-Cal (131 ± 14 versus 349 ± 32 mg/day, respectively; p < 0.001). We found significantly lower urinary calcium excretion but not calcium absorption in black girls compared with white girls. Conclusions: Very low calcium intakes are only partially adapted to by increased absorption and decreased excretion. Very low calcium intakes place both white and black pubertal girls at substantial risk for inadequate calcium retention.",
keywords = "Adolescents, Calcium absorption, Puberty, Stable isotopes, Urinary calcium",
author = "Abrams, {Steven A.} and Griffin, {Ian J.} and Hicks, {Penni D.} and Gunn, {Sheila K.}",
year = "2004",
month = "5",
doi = "10.1359/JBMR.040122",
language = "English (US)",
volume = "19",
pages = "759--763",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Pubertal girls only partially adapt to low dietary calcium intakes

AU - Abrams, Steven A.

AU - Griffin, Ian J.

AU - Hicks, Penni D.

AU - Gunn, Sheila K.

PY - 2004/5

Y1 - 2004/5

N2 - We evaluated the effects of low calcium in the diets of young adolescent girls. We measured calcium absorption and excretion using stable isotopes. We found partial adaptation to low intakes but a persistent large deficit relative to recommended intakes. Low calcium intakes pose a substantial risk of inadequate calcium retention. Introduction: A substantial number of adolescent girls in the United States have habitual calcium intakes <500 mg/day (about 40% of the current recommended intake). The ability to adapt to these very low intakes by increasing calcium absorption and decreasing calcium excretion is not known. We sought to determine the effects of recommended (REC-Ca) versus very low (LO-Ca) calcium intakes on calcium absorption and excretion in white and black girls. Materials and Methods: Pubertal, but premenarcheal girls, were adapted to low or recommended calcium intakes for at least 2 weeks before each study. Calcium absorption (n = 51) and endogenous fecal calcium excretion (n = 36 of the 51) were determined by dual-tracer stable isotope studies. Subjects were then switched to the other diet for at least 6 weeks, and the study was repeated. Results: Calcium intake was 389 ± 10 mg/day on LO-Ca and 1259 ± 35 mg/day on REC-Ca diets. Fractional absorption increased from 44.9 ± 1.9% on REC-Ca to 63.4 ± 1.7% on LO-Ca (p < 0.01), but the net calcium absorption remained less than one-half the value on LO-Ca as on REC-Ca. Despite decreases in both endogenous fecal calcium excretion and urinary calcium excretion, net calcium balance was much lower on LO-Ca compared with REC-Cal (131 ± 14 versus 349 ± 32 mg/day, respectively; p < 0.001). We found significantly lower urinary calcium excretion but not calcium absorption in black girls compared with white girls. Conclusions: Very low calcium intakes are only partially adapted to by increased absorption and decreased excretion. Very low calcium intakes place both white and black pubertal girls at substantial risk for inadequate calcium retention.

AB - We evaluated the effects of low calcium in the diets of young adolescent girls. We measured calcium absorption and excretion using stable isotopes. We found partial adaptation to low intakes but a persistent large deficit relative to recommended intakes. Low calcium intakes pose a substantial risk of inadequate calcium retention. Introduction: A substantial number of adolescent girls in the United States have habitual calcium intakes <500 mg/day (about 40% of the current recommended intake). The ability to adapt to these very low intakes by increasing calcium absorption and decreasing calcium excretion is not known. We sought to determine the effects of recommended (REC-Ca) versus very low (LO-Ca) calcium intakes on calcium absorption and excretion in white and black girls. Materials and Methods: Pubertal, but premenarcheal girls, were adapted to low or recommended calcium intakes for at least 2 weeks before each study. Calcium absorption (n = 51) and endogenous fecal calcium excretion (n = 36 of the 51) were determined by dual-tracer stable isotope studies. Subjects were then switched to the other diet for at least 6 weeks, and the study was repeated. Results: Calcium intake was 389 ± 10 mg/day on LO-Ca and 1259 ± 35 mg/day on REC-Ca diets. Fractional absorption increased from 44.9 ± 1.9% on REC-Ca to 63.4 ± 1.7% on LO-Ca (p < 0.01), but the net calcium absorption remained less than one-half the value on LO-Ca as on REC-Ca. Despite decreases in both endogenous fecal calcium excretion and urinary calcium excretion, net calcium balance was much lower on LO-Ca compared with REC-Cal (131 ± 14 versus 349 ± 32 mg/day, respectively; p < 0.001). We found significantly lower urinary calcium excretion but not calcium absorption in black girls compared with white girls. Conclusions: Very low calcium intakes are only partially adapted to by increased absorption and decreased excretion. Very low calcium intakes place both white and black pubertal girls at substantial risk for inadequate calcium retention.

KW - Adolescents

KW - Calcium absorption

KW - Puberty

KW - Stable isotopes

KW - Urinary calcium

UR - http://www.scopus.com/inward/record.url?scp=3242745351&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3242745351&partnerID=8YFLogxK

U2 - 10.1359/JBMR.040122

DO - 10.1359/JBMR.040122

M3 - Article

C2 - 15068499

AN - SCOPUS:3242745351

VL - 19

SP - 759

EP - 763

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 5

ER -