Pubertal development in girls by breast cancer family history: The LEGACY girls cohort

Mary Beth Terry, Theresa H Keegan, Lauren C. Houghton, Mandy Goldberg, Irene L. Andrulis, Mary B. Daly, Saundra S. Buys, Ying Wei, Alice S. Whittemore, Angeline Protacio, Angela R. Bradbury, Wendy K. Chung, Julia A. Knight, Esther M. John

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Pubertal milestones, such as onset of breast development and menstruation, play an important role in breast cancer etiology. It is unclear if these milestones are different in girls with a first- or second-degree breast cancer family history (BCFH). Methods: In the LEGACY Girls Study (n = 1040), we examined whether three mother/guardian-reported pubertal milestones (having reached Tanner Stage 2 or higher (T2+) for breast and pubic hair development, and having started menstruation) differed by BCFH. We also examined whether associations between body size and race/ethnicity and pubertal milestones were modified by BCFH. We used mother/guardian reports as the primary measure of pubertal milestones, but also conducted sensitivity analyses using clinical Tanner measurements available for a subcohort (n = 204). We analyzed cross-sectional baseline data with logistic regression models for the entire cohort, and longitudinal data with Weibull survival models for the subcohort of girls that were aged 5-7 years at baseline (n = 258). Results: BCFH was modestly, but not statistically significantly, associated with Breast T2+ (odds ratio (OR) = 1.36, 95% confidence interval (CI) = 0.88-2.10), with a stronger association seen in the subcohort of girls with clinical breast Tanner staging (OR = 2.20, 95% CI = 0.91-5.32). In a longitudinal analysis of girls who were aged 5-7 years at baseline, BCFH was associated with a 50% increased rate of having early breast development (hazard ratio (HR) = 1.49, 95% CI = 1.0-2.21). This association increased to twofold in girls who were not overweight at baseline (HR = 2.04, 95% CI = 1.29-3.21). BCFH was not associated with pubic hair development and post-menarche status. The median interval between onset of breast development and menarche was longer for BCFH+ than BCFH- girls (2.3 versus 1.7 years), suggesting a slower developmental tempo for BCFH+ girls. Associations between pubertal milestones and body size and race/ethnicity were similar in girls with or without a BCFH. For example, weight was positively associated with Breast T2+ in both girls with (OR = 1.06 per 1 kg, 95% CI = 1.03-1.10) and without (OR = 1.14 per 1 kg, 95% CI = 1.04-1.24) a BCFH. Conclusions: These results suggest that BCFH may be related to earlier breast development and slower pubertal tempo independent of body size and race/ethnicity.

Original languageEnglish (US)
Article number69
JournalBreast Cancer Research
Volume19
Issue number1
DOIs
StatePublished - Jun 8 2017

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Breast Neoplasms
Breast
Confidence Intervals
Body Size
Odds Ratio
Menarche
Menstruation
Hair
Logistic Models
Mothers
Weights and Measures
Survival

Keywords

  • BMI
  • Breast cancer
  • Breast cancer family history
  • Menarche
  • Pubertal development

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Terry, M. B., Keegan, T. H., Houghton, L. C., Goldberg, M., Andrulis, I. L., Daly, M. B., ... John, E. M. (2017). Pubertal development in girls by breast cancer family history: The LEGACY girls cohort. Breast Cancer Research, 19(1), [69]. https://doi.org/10.1186/s13058-017-0849-y

Pubertal development in girls by breast cancer family history : The LEGACY girls cohort. / Terry, Mary Beth; Keegan, Theresa H; Houghton, Lauren C.; Goldberg, Mandy; Andrulis, Irene L.; Daly, Mary B.; Buys, Saundra S.; Wei, Ying; Whittemore, Alice S.; Protacio, Angeline; Bradbury, Angela R.; Chung, Wendy K.; Knight, Julia A.; John, Esther M.

In: Breast Cancer Research, Vol. 19, No. 1, 69, 08.06.2017.

Research output: Contribution to journalArticle

Terry, MB, Keegan, TH, Houghton, LC, Goldberg, M, Andrulis, IL, Daly, MB, Buys, SS, Wei, Y, Whittemore, AS, Protacio, A, Bradbury, AR, Chung, WK, Knight, JA & John, EM 2017, 'Pubertal development in girls by breast cancer family history: The LEGACY girls cohort', Breast Cancer Research, vol. 19, no. 1, 69. https://doi.org/10.1186/s13058-017-0849-y
Terry, Mary Beth ; Keegan, Theresa H ; Houghton, Lauren C. ; Goldberg, Mandy ; Andrulis, Irene L. ; Daly, Mary B. ; Buys, Saundra S. ; Wei, Ying ; Whittemore, Alice S. ; Protacio, Angeline ; Bradbury, Angela R. ; Chung, Wendy K. ; Knight, Julia A. ; John, Esther M. / Pubertal development in girls by breast cancer family history : The LEGACY girls cohort. In: Breast Cancer Research. 2017 ; Vol. 19, No. 1.
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abstract = "Background: Pubertal milestones, such as onset of breast development and menstruation, play an important role in breast cancer etiology. It is unclear if these milestones are different in girls with a first- or second-degree breast cancer family history (BCFH). Methods: In the LEGACY Girls Study (n = 1040), we examined whether three mother/guardian-reported pubertal milestones (having reached Tanner Stage 2 or higher (T2+) for breast and pubic hair development, and having started menstruation) differed by BCFH. We also examined whether associations between body size and race/ethnicity and pubertal milestones were modified by BCFH. We used mother/guardian reports as the primary measure of pubertal milestones, but also conducted sensitivity analyses using clinical Tanner measurements available for a subcohort (n = 204). We analyzed cross-sectional baseline data with logistic regression models for the entire cohort, and longitudinal data with Weibull survival models for the subcohort of girls that were aged 5-7 years at baseline (n = 258). Results: BCFH was modestly, but not statistically significantly, associated with Breast T2+ (odds ratio (OR) = 1.36, 95{\%} confidence interval (CI) = 0.88-2.10), with a stronger association seen in the subcohort of girls with clinical breast Tanner staging (OR = 2.20, 95{\%} CI = 0.91-5.32). In a longitudinal analysis of girls who were aged 5-7 years at baseline, BCFH was associated with a 50{\%} increased rate of having early breast development (hazard ratio (HR) = 1.49, 95{\%} CI = 1.0-2.21). This association increased to twofold in girls who were not overweight at baseline (HR = 2.04, 95{\%} CI = 1.29-3.21). BCFH was not associated with pubic hair development and post-menarche status. The median interval between onset of breast development and menarche was longer for BCFH+ than BCFH- girls (2.3 versus 1.7 years), suggesting a slower developmental tempo for BCFH+ girls. Associations between pubertal milestones and body size and race/ethnicity were similar in girls with or without a BCFH. For example, weight was positively associated with Breast T2+ in both girls with (OR = 1.06 per 1 kg, 95{\%} CI = 1.03-1.10) and without (OR = 1.14 per 1 kg, 95{\%} CI = 1.04-1.24) a BCFH. Conclusions: These results suggest that BCFH may be related to earlier breast development and slower pubertal tempo independent of body size and race/ethnicity.",
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author = "Terry, {Mary Beth} and Keegan, {Theresa H} and Houghton, {Lauren C.} and Mandy Goldberg and Andrulis, {Irene L.} and Daly, {Mary B.} and Buys, {Saundra S.} and Ying Wei and Whittemore, {Alice S.} and Angeline Protacio and Bradbury, {Angela R.} and Chung, {Wendy K.} and Knight, {Julia A.} and John, {Esther M.}",
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TY - JOUR

T1 - Pubertal development in girls by breast cancer family history

T2 - The LEGACY girls cohort

AU - Terry, Mary Beth

AU - Keegan, Theresa H

AU - Houghton, Lauren C.

AU - Goldberg, Mandy

AU - Andrulis, Irene L.

AU - Daly, Mary B.

AU - Buys, Saundra S.

AU - Wei, Ying

AU - Whittemore, Alice S.

AU - Protacio, Angeline

AU - Bradbury, Angela R.

AU - Chung, Wendy K.

AU - Knight, Julia A.

AU - John, Esther M.

PY - 2017/6/8

Y1 - 2017/6/8

N2 - Background: Pubertal milestones, such as onset of breast development and menstruation, play an important role in breast cancer etiology. It is unclear if these milestones are different in girls with a first- or second-degree breast cancer family history (BCFH). Methods: In the LEGACY Girls Study (n = 1040), we examined whether three mother/guardian-reported pubertal milestones (having reached Tanner Stage 2 or higher (T2+) for breast and pubic hair development, and having started menstruation) differed by BCFH. We also examined whether associations between body size and race/ethnicity and pubertal milestones were modified by BCFH. We used mother/guardian reports as the primary measure of pubertal milestones, but also conducted sensitivity analyses using clinical Tanner measurements available for a subcohort (n = 204). We analyzed cross-sectional baseline data with logistic regression models for the entire cohort, and longitudinal data with Weibull survival models for the subcohort of girls that were aged 5-7 years at baseline (n = 258). Results: BCFH was modestly, but not statistically significantly, associated with Breast T2+ (odds ratio (OR) = 1.36, 95% confidence interval (CI) = 0.88-2.10), with a stronger association seen in the subcohort of girls with clinical breast Tanner staging (OR = 2.20, 95% CI = 0.91-5.32). In a longitudinal analysis of girls who were aged 5-7 years at baseline, BCFH was associated with a 50% increased rate of having early breast development (hazard ratio (HR) = 1.49, 95% CI = 1.0-2.21). This association increased to twofold in girls who were not overweight at baseline (HR = 2.04, 95% CI = 1.29-3.21). BCFH was not associated with pubic hair development and post-menarche status. The median interval between onset of breast development and menarche was longer for BCFH+ than BCFH- girls (2.3 versus 1.7 years), suggesting a slower developmental tempo for BCFH+ girls. Associations between pubertal milestones and body size and race/ethnicity were similar in girls with or without a BCFH. For example, weight was positively associated with Breast T2+ in both girls with (OR = 1.06 per 1 kg, 95% CI = 1.03-1.10) and without (OR = 1.14 per 1 kg, 95% CI = 1.04-1.24) a BCFH. Conclusions: These results suggest that BCFH may be related to earlier breast development and slower pubertal tempo independent of body size and race/ethnicity.

AB - Background: Pubertal milestones, such as onset of breast development and menstruation, play an important role in breast cancer etiology. It is unclear if these milestones are different in girls with a first- or second-degree breast cancer family history (BCFH). Methods: In the LEGACY Girls Study (n = 1040), we examined whether three mother/guardian-reported pubertal milestones (having reached Tanner Stage 2 or higher (T2+) for breast and pubic hair development, and having started menstruation) differed by BCFH. We also examined whether associations between body size and race/ethnicity and pubertal milestones were modified by BCFH. We used mother/guardian reports as the primary measure of pubertal milestones, but also conducted sensitivity analyses using clinical Tanner measurements available for a subcohort (n = 204). We analyzed cross-sectional baseline data with logistic regression models for the entire cohort, and longitudinal data with Weibull survival models for the subcohort of girls that were aged 5-7 years at baseline (n = 258). Results: BCFH was modestly, but not statistically significantly, associated with Breast T2+ (odds ratio (OR) = 1.36, 95% confidence interval (CI) = 0.88-2.10), with a stronger association seen in the subcohort of girls with clinical breast Tanner staging (OR = 2.20, 95% CI = 0.91-5.32). In a longitudinal analysis of girls who were aged 5-7 years at baseline, BCFH was associated with a 50% increased rate of having early breast development (hazard ratio (HR) = 1.49, 95% CI = 1.0-2.21). This association increased to twofold in girls who were not overweight at baseline (HR = 2.04, 95% CI = 1.29-3.21). BCFH was not associated with pubic hair development and post-menarche status. The median interval between onset of breast development and menarche was longer for BCFH+ than BCFH- girls (2.3 versus 1.7 years), suggesting a slower developmental tempo for BCFH+ girls. Associations between pubertal milestones and body size and race/ethnicity were similar in girls with or without a BCFH. For example, weight was positively associated with Breast T2+ in both girls with (OR = 1.06 per 1 kg, 95% CI = 1.03-1.10) and without (OR = 1.14 per 1 kg, 95% CI = 1.04-1.24) a BCFH. Conclusions: These results suggest that BCFH may be related to earlier breast development and slower pubertal tempo independent of body size and race/ethnicity.

KW - BMI

KW - Breast cancer

KW - Breast cancer family history

KW - Menarche

KW - Pubertal development

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