PTEN: A promising pharmacological target to enhance epithelial wound healing

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

PI3Ks (phosphoinositide-3 kinases) produce PIP3 (phosphatidylinositol(3,4, 5)-trisphosphate) which mediates signals for cell survival and proliferation. The tumour suppressor PTEN (phosphatase and tensin homologue) dephosphorylates PIP3 and is a key negative regulator of PI3K signalling. Recent research highlighted important roles for PI3K/PTEN in cell polarization and directional cell migration, pointing to a significant role for PTEN in wound healing where spatially organized tissue growth is essential. Lai et al. (in this issue of British Journal of Pharmacology) have moved a step closer in utilizing PTEN for wound healing through pharmacological inhibition. Two vanadium derivative inhibitors targeting PTEN significantly elevated the level of phosphorylated Akt (protein kinase B) and nearly doubled the wound healing rate in monolayer cultures of lung and airway epithelial cells. Damage to airway and lung epithelia underlies a wide spectrum of significant clinical conditions. With further experiments, this promising approach may find potential clinical use in situations where enhanced wound healing of pulmonary and other epithelia is important.

Original languageEnglish (US)
Pages (from-to)1141-1144
Number of pages4
JournalBritish Journal of Pharmacology
Volume152
Issue number8
DOIs
StatePublished - Dec 2007

Keywords

  • Akt/protein kinase B
  • Bisperoxovanadium compounds
  • Cell migration
  • Epithelium
  • PI3 kinase
  • PTEN
  • Wound healing

ASJC Scopus subject areas

  • Pharmacology

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