Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment

Stephanie M. Sansone, Keith F. Widaman, Scott S. Hall, Allan L. Reiss, Amy Lightbody, Walter E. Kaufmann, Elizabeth Berry-Kravis, Ave Lachiewicz, Elaine C. Brown, David R Hessl

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist- Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3-25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials.

Original languageEnglish (US)
Pages (from-to)1377-1392
Number of pages16
JournalJournal of Autism and Developmental Disorders
Volume42
Issue number7
DOIs
StatePublished - Jul 2012

Fingerprint

Fragile X Syndrome
Checklist
Psychometrics
Outcome Assessment (Health Care)
Lethargy
Neurobiology
Intellectual Disability
Statistical Factor Analysis
Clinical Trials
Sensitivity and Specificity

Keywords

  • Autism
  • Factor analysis
  • FMR1 gene
  • Fragile X syndrome
  • Rating scale
  • Social avoidance

ASJC Scopus subject areas

  • Developmental and Educational Psychology

Cite this

Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment. / Sansone, Stephanie M.; Widaman, Keith F.; Hall, Scott S.; Reiss, Allan L.; Lightbody, Amy; Kaufmann, Walter E.; Berry-Kravis, Elizabeth; Lachiewicz, Ave; Brown, Elaine C.; Hessl, David R.

In: Journal of Autism and Developmental Disorders, Vol. 42, No. 7, 07.2012, p. 1377-1392.

Research output: Contribution to journalArticle

Sansone, SM, Widaman, KF, Hall, SS, Reiss, AL, Lightbody, A, Kaufmann, WE, Berry-Kravis, E, Lachiewicz, A, Brown, EC & Hessl, DR 2012, 'Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment', Journal of Autism and Developmental Disorders, vol. 42, no. 7, pp. 1377-1392. https://doi.org/10.1007/s10803-011-1370-2
Sansone, Stephanie M. ; Widaman, Keith F. ; Hall, Scott S. ; Reiss, Allan L. ; Lightbody, Amy ; Kaufmann, Walter E. ; Berry-Kravis, Elizabeth ; Lachiewicz, Ave ; Brown, Elaine C. ; Hessl, David R. / Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment. In: Journal of Autism and Developmental Disorders. 2012 ; Vol. 42, No. 7. pp. 1377-1392.
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