Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment

Stephanie M. Sansone, Keith F. Widaman, Scott S. Hall, Allan L. Reiss, Amy Lightbody, Walter E. Kaufmann, Elizabeth Berry-Kravis, Ave Lachiewicz, Elaine C. Brown, David R Hessl

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist- Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3-25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials.

Original languageEnglish (US)
Pages (from-to)1377-1392
Number of pages16
JournalJournal of Autism and Developmental Disorders
Volume42
Issue number7
DOIs
StatePublished - Jul 2012

Keywords

  • Autism
  • Factor analysis
  • FMR1 gene
  • Fragile X syndrome
  • Rating scale
  • Social avoidance

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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