Psychological Traits, Heart Rate Variability, and Risk of Coronary Heart Disease in Healthy Aging Women - The Women's Health Initiative

Elena Salmoirago-Blotcher, Kathleen M. Hovey, Cristopher A. Andrews, Matthew Allison, Robert L. Brunner, Nathalie L. Denburg, Charles Eaton, Lorena Garcia, Shawnita M. Sealy-Jefferson, Oleg Zaslavsky, Joseph Kang, Lenny López, Stephen G. Post, Hilary Tindle, Sylvia Wassertheil-Smoller

Research output: Contribution to journalArticle

Abstract

Objective: Psychological traits such as optimism and hostility affect coronary heart disease (CHD) risk, but mechanisms for this association are unclear. We hypothesized that optimism and hostility may affect CHD risk via changes in heart rate variability (HRV). Methods: We conducted a longitudinal analysis using data from the Women's Health Initiative Myocardial Ischemia and Migraine Study. Participants underwent 24-hour ambulatory electrocardiogram monitoring 3 years after enrollment. Optimism (Life Orientation Test-Revised), cynical hostility (Cook-Medley), demographics, and coronary risk factors were assessed at baseline. HRV measures included standard deviation of average N-N intervals (SDNN); standard deviation of average N-N intervals for 5 minutes (SDANN); and average heart rate (HR). CHD was defined as the first occurrence of myocardial infarction, angina, coronary angioplasty, and bypass grafting. Linear and Cox regression models adjusted for CHD risk factors were used to examine, respectively, associations between optimism, hostility, and HRV and between HRV and CHD risk. Results: Final analyses included 2655 women. Although optimism was not associated with HRV, hostility was inversely associated with HRV 3 years later (SDANN: adjusted β = -0.54; 95% CI = -0.97 to -0.11; SDNN: -0.49; 95% CI = -0.93 to -0.05). HRV was inversely associated with CHD risk; for each 10-millisecond increase in SDNN or SDANN, there was a decrease in CHD risk of 9% (p =.023) and 12% (p =.006), respectively. Conclusions: HRV did not play a major role in explaining why more optimistic women seem to be somewhat protected from CHD risk. Although hostility was inversely associated with HRV, its role in explaining the association between hostility and CHD risk remains to be established.

Original languageEnglish (US)
Pages (from-to)256-264
Number of pages9
JournalPsychosomatic Medicine
Volume81
Issue number3
DOIs
StatePublished - Apr 1 2019

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Women's Health
Coronary Disease
Hostility
Heart Rate
Psychology
Ambulatory Monitoring
Migraine Disorders
Angioplasty
Proportional Hazards Models
Myocardial Ischemia
Linear Models
Electrocardiography
Myocardial Infarction
Demography
Optimism

Keywords

  • coronary heart disease
  • heart rate variability
  • hostility
  • optimism
  • women's health

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

Cite this

Salmoirago-Blotcher, E., Hovey, K. M., Andrews, C. A., Allison, M., Brunner, R. L., Denburg, N. L., ... Wassertheil-Smoller, S. (2019). Psychological Traits, Heart Rate Variability, and Risk of Coronary Heart Disease in Healthy Aging Women - The Women's Health Initiative. Psychosomatic Medicine, 81(3), 256-264. https://doi.org/10.1097/PSY.0000000000000672

Psychological Traits, Heart Rate Variability, and Risk of Coronary Heart Disease in Healthy Aging Women - The Women's Health Initiative. / Salmoirago-Blotcher, Elena; Hovey, Kathleen M.; Andrews, Cristopher A.; Allison, Matthew; Brunner, Robert L.; Denburg, Nathalie L.; Eaton, Charles; Garcia, Lorena; Sealy-Jefferson, Shawnita M.; Zaslavsky, Oleg; Kang, Joseph; López, Lenny; Post, Stephen G.; Tindle, Hilary; Wassertheil-Smoller, Sylvia.

In: Psychosomatic Medicine, Vol. 81, No. 3, 01.04.2019, p. 256-264.

Research output: Contribution to journalArticle

Salmoirago-Blotcher, E, Hovey, KM, Andrews, CA, Allison, M, Brunner, RL, Denburg, NL, Eaton, C, Garcia, L, Sealy-Jefferson, SM, Zaslavsky, O, Kang, J, López, L, Post, SG, Tindle, H & Wassertheil-Smoller, S 2019, 'Psychological Traits, Heart Rate Variability, and Risk of Coronary Heart Disease in Healthy Aging Women - The Women's Health Initiative', Psychosomatic Medicine, vol. 81, no. 3, pp. 256-264. https://doi.org/10.1097/PSY.0000000000000672
Salmoirago-Blotcher, Elena ; Hovey, Kathleen M. ; Andrews, Cristopher A. ; Allison, Matthew ; Brunner, Robert L. ; Denburg, Nathalie L. ; Eaton, Charles ; Garcia, Lorena ; Sealy-Jefferson, Shawnita M. ; Zaslavsky, Oleg ; Kang, Joseph ; López, Lenny ; Post, Stephen G. ; Tindle, Hilary ; Wassertheil-Smoller, Sylvia. / Psychological Traits, Heart Rate Variability, and Risk of Coronary Heart Disease in Healthy Aging Women - The Women's Health Initiative. In: Psychosomatic Medicine. 2019 ; Vol. 81, No. 3. pp. 256-264.
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