Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers

P. E. Adams, J. S. Adams, D. V. Nguyen, David R Hessl, James A Brunberg, Flora Tassone, W. Zhang, K. Koldewyn, S. M. Rivera, J. Grigsby, Lin Zhang, Charles DeCarli, Paul J Hagerman, Randi J Hagerman

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder occurring in male and occasional female carriers of a premutation expansion (55-200 CGG repeats) of the fragile X mental retardation 1 gene (FMR1). This study assessed the relationship between hippocampal volume and psychological symptoms in carriers, both with and without FXTAS, and controls. Volumetric MRI measures, clinical staging, cognitive testing, molecular analysis, and measures of psychological symptoms were performed for female premutation carriers both with FXTAS (n = 16, age: 57.50±12.46) and without FXTAS (n = 17, age: 44.94±11.23), in genetically normal female controls (n = 8, age: 50.63±11.43), male carriers with FXTAS (n = 34, age: 66.44±6.77) and without FXTAS (n = 21, age: 52.38±12.11), and genetically normal male controls (n = 30, age: 57.20±14.12). We examined the relationship between psychological symptom severity and hippocampal volume, as well as correlations with molecular data. We found a significant negative correlation between total hippocampal volume and anxiety in female carriers, with and without FXTAS. This finding was mainly driven by the significant negative correlation between right hippocampal volume and anxiety. Other anxiety-related subscales also correlated with the right hippocampus in females. In male carriers with and without FXTAS, only paranoid ideation negatively correlated with hippocampal volume. Female premutation carriers demonstrated a negative association between hippocampal volume and the severity of anxiety-related psychological symptoms. Though the presentation of FXTAS symptoms is less common in females, anxiety-related problems are common both prior to and after the onset of FXTAS, and may be related to hippocampal changes.

Original languageEnglish (US)
Pages (from-to)775-785
Number of pages11
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Issue number3
StatePublished - Apr 2010


  • Anxiety
  • Fragile X
  • Hippocampus
  • Premutation

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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