Abstract
We utilized a sample of 299 adult females aged between 19 and 86years, carrying fragile X mental retardation (FMR1) alleles with small CCG expansions ranging from 50 to 141 repeats to analyse the relationships between psychological symptoms as assessed by the Symptom Checklist-90-Revised (SCL-90-R) and the size of the CGG repeat in the FMR1 gene. There were highly significant (negative) correlations between the size of the CGG repeat and a great majority of SCL-90-R subscale scores and all the global indices, suggesting that carriers of premutations in the mid-size CGG repeat range may be at greatest risk for the development of psychiatric disorder.
Original language | English (US) |
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Pages (from-to) | 173-178 |
Number of pages | 6 |
Journal | Clinical Genetics |
Volume | 87 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2015 |
Keywords
- CGG repeat size
- FMR1 premutation
- Premutation female carriers
- Psychological symptoms
- Regression analysis
ASJC Scopus subject areas
- Genetics(clinical)
- Genetics