Psychiatric symptoms in boys with fragile X syndrome: A comparison with nonsyndromic autism spectrum disorder

Angela John Thurman, Andrea McDuffie, Randi J Hagerman, Leonard J Abbeduto

Research output: Contribution to journalArticle

42 Scopus citations


In the present study, we examined the profile of psychiatric symptoms in boys with fragile X syndrome (FXS) using a parent report instrument. In addition, by comparing boys with FXS to boys with nonsyndromic autism spectrum disorder (ASD) utilizing multiple matching strategies, we examined between-group differences in the types of psychiatric symptoms observed and in the strength of their concurrent associations. Across all matching strategies, symptoms of manic/hyperactive behaviors and general anxiety were more frequently reported for boys with FXS than for boys with nonsyndromic ASD. Results also indicated a positive association between social avoidance and general anxiety in FXS that was stronger than that observed in nonsyndromic ASD across all matching strategies. Theoretical and treatment implications are discussed.

Original languageEnglish (US)
Pages (from-to)1072-1086
Number of pages15
JournalResearch in Developmental Disabilities
Issue number5
StatePublished - 2014



  • Anxiety
  • Autism spectrum disorder
  • Fragile X syndrome
  • Hyperactivity
  • Psychiatric symptoms
  • Social avoidance

ASJC Scopus subject areas

  • Clinical Psychology
  • Developmental and Educational Psychology

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