Abstract
Objective: To estimate the frequency of depressive symptoms and selected psychiatric disorders in the Women's Health Initiative Memory Study (WHIMS) cohort and related them to cognitive syndromes. Design: WHIMS was a randomized, double-blinded, placebo-controlled prevention clinical trial examining whether opposed and unopposed hormone therapy reduced the risk of dementia in healthy postmenopausal women. Participants scoring below a designated cutpoint on a cognitive screener received a comprehensive neuropsychiatric workup and adjudicated outcome of no cognitive impairment, mild cognitive impairment, or probable dementia. Participants: Seven thousand four hundred seventy-nine WHIMS participants between age 65 and 79 years and free of dementia at the time of enrollment in WHIMS. Five hundred twenty-one unique participants contributed complete data required for these analyses. Measures: Depressive symptoms were measured with the 15-item Geriatric Depression Scale and the presence of selected psychiatric disorders (major depression, generalized anxiety, and panic and alcohol abuse) was made using the PRIME-MD. Results: The 18% of women had at least one psychiatric disorder with depression being the most common (16%) followed by general anxiety or panic (6%) and alcohol abuse (1%). Depression and the presence of a psychiatric disorder were associated with impaired cognitive status. Participants having a psychiatric disorder were more than twice as likely to be diagnosed with cognitive impairment as those with no psychiatric disorder (odds ratio = 2.06, 95% confidence interval = 1.17-3.60). Older age, white race, and diabetes were also associated with cognitive impairment. Conclusion:The frequency of a psychiatric disorder is associated with poorer cognitive functioning among older women enrolled in WHIMS. That approximately one in five women had a probable psychiatric disorder, most typically depression, highlights the need for greater detection and treatment efforts in this population.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 177-186 |
| Number of pages | 10 |
| Journal | American Journal of Geriatric Psychiatry |
| Volume | 18 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2010 |
| Externally published | Yes |
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Keywords
- Cognition
- Comorbidity
- MCI
- Psychiatric disorders
- Risk of dementia
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Psychiatry and Mental health
Cite this
Psychiatric disorders and cognitive dysfunction among older, postmenopausal women : Results from the women's health initiative memory study. / Colenda, Christopher C.; Legault, Claudine; Rapp, Stephen R.; Debon, Margaret W.; Hogan, Patricia; Wallace, Robert; Hershey, Linda; Ockene, Judith; Whitmer, Rachel; Phillips, Lawrence S.; Sarto, Gloria E.
In: American Journal of Geriatric Psychiatry, Vol. 18, No. 2, 01.01.2010, p. 177-186.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Psychiatric disorders and cognitive dysfunction among older, postmenopausal women
T2 - Results from the women's health initiative memory study
AU - Colenda, Christopher C.
AU - Legault, Claudine
AU - Rapp, Stephen R.
AU - Debon, Margaret W.
AU - Hogan, Patricia
AU - Wallace, Robert
AU - Hershey, Linda
AU - Ockene, Judith
AU - Whitmer, Rachel
AU - Phillips, Lawrence S.
AU - Sarto, Gloria E.
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Objective: To estimate the frequency of depressive symptoms and selected psychiatric disorders in the Women's Health Initiative Memory Study (WHIMS) cohort and related them to cognitive syndromes. Design: WHIMS was a randomized, double-blinded, placebo-controlled prevention clinical trial examining whether opposed and unopposed hormone therapy reduced the risk of dementia in healthy postmenopausal women. Participants scoring below a designated cutpoint on a cognitive screener received a comprehensive neuropsychiatric workup and adjudicated outcome of no cognitive impairment, mild cognitive impairment, or probable dementia. Participants: Seven thousand four hundred seventy-nine WHIMS participants between age 65 and 79 years and free of dementia at the time of enrollment in WHIMS. Five hundred twenty-one unique participants contributed complete data required for these analyses. Measures: Depressive symptoms were measured with the 15-item Geriatric Depression Scale and the presence of selected psychiatric disorders (major depression, generalized anxiety, and panic and alcohol abuse) was made using the PRIME-MD. Results: The 18% of women had at least one psychiatric disorder with depression being the most common (16%) followed by general anxiety or panic (6%) and alcohol abuse (1%). Depression and the presence of a psychiatric disorder were associated with impaired cognitive status. Participants having a psychiatric disorder were more than twice as likely to be diagnosed with cognitive impairment as those with no psychiatric disorder (odds ratio = 2.06, 95% confidence interval = 1.17-3.60). Older age, white race, and diabetes were also associated with cognitive impairment. Conclusion:The frequency of a psychiatric disorder is associated with poorer cognitive functioning among older women enrolled in WHIMS. That approximately one in five women had a probable psychiatric disorder, most typically depression, highlights the need for greater detection and treatment efforts in this population.
AB - Objective: To estimate the frequency of depressive symptoms and selected psychiatric disorders in the Women's Health Initiative Memory Study (WHIMS) cohort and related them to cognitive syndromes. Design: WHIMS was a randomized, double-blinded, placebo-controlled prevention clinical trial examining whether opposed and unopposed hormone therapy reduced the risk of dementia in healthy postmenopausal women. Participants scoring below a designated cutpoint on a cognitive screener received a comprehensive neuropsychiatric workup and adjudicated outcome of no cognitive impairment, mild cognitive impairment, or probable dementia. Participants: Seven thousand four hundred seventy-nine WHIMS participants between age 65 and 79 years and free of dementia at the time of enrollment in WHIMS. Five hundred twenty-one unique participants contributed complete data required for these analyses. Measures: Depressive symptoms were measured with the 15-item Geriatric Depression Scale and the presence of selected psychiatric disorders (major depression, generalized anxiety, and panic and alcohol abuse) was made using the PRIME-MD. Results: The 18% of women had at least one psychiatric disorder with depression being the most common (16%) followed by general anxiety or panic (6%) and alcohol abuse (1%). Depression and the presence of a psychiatric disorder were associated with impaired cognitive status. Participants having a psychiatric disorder were more than twice as likely to be diagnosed with cognitive impairment as those with no psychiatric disorder (odds ratio = 2.06, 95% confidence interval = 1.17-3.60). Older age, white race, and diabetes were also associated with cognitive impairment. Conclusion:The frequency of a psychiatric disorder is associated with poorer cognitive functioning among older women enrolled in WHIMS. That approximately one in five women had a probable psychiatric disorder, most typically depression, highlights the need for greater detection and treatment efforts in this population.
KW - Cognition
KW - Comorbidity
KW - MCI
KW - Psychiatric disorders
KW - Risk of dementia
UR - http://www.scopus.com/inward/record.url?scp=75149177206&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75149177206&partnerID=8YFLogxK
U2 - 10.1097/JGP.0b013e3181c65864
DO - 10.1097/JGP.0b013e3181c65864
M3 - Article
C2 - 20104074
AN - SCOPUS:75149177206
VL - 18
SP - 177
EP - 186
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
SN - 1064-7481
IS - 2
ER -