Psoriatic keratinocytes express high levels of nerve growth factor

Siba P Raychaudhuri, Wen Yue Jiang, Eugene M. Farber

Research output: Contribution to journalArticle

107 Scopus citations

Abstract

Many investigators have reported proliferation of terminal cutaneous nerves and upregulation of various neuropeptides (substance P, vasoactive intestinal polypeptide, calcitonin gene-related peptide) in psoriatic lesions. Nerve growth factor promotes growth of nerves and causes upregulation of neuropeptides like substance P and calcitonin gene-related peptide. In this study we investigated the expression of nerve growth factor in psoriatic lesions, non-lesional psoriatic skin, lichen planus and normal control skin. Immunoperoxidase staining was applied on cryosections prepared from snap-frozen biopsy specimens. The primary antibody used was a polyclonal anti-NGF-β antibody. Nerve growth factor was detected only in the keratinocytes. In psoriatic tissue the number of keratinocytes per square millimeter of epidermis positive for nerve growth factor was 84.74 ± 46.3 compared to 44.8 ± 29.9, 18.9 ± 11.8 and 7.5 ± 16.9, respectively, in non- lesional psoriatic skin, normal skin and lichen planus. Increased expression of nerve growth factor substantiates larger numbers of terminal cutaneous nerves and upregulations of substance P and calcitonin gene-related peptide in psoriatic lesions. In addition, nerve growth factor is mitogenic to keratinocytes, activates T-lymphocytes and can induce migration of inflammatory cellular infiltrates, histological features characteristic of psoriasis.

Original languageEnglish (US)
Pages (from-to)84-86
Number of pages3
JournalActa Dermato-Venereologica
Volume78
Issue number2
DOIs
StatePublished - 1998
Externally publishedYes

Keywords

  • Neurogenic inflammation
  • NGF
  • Pathogenesis
  • Psoriasis

ASJC Scopus subject areas

  • Dermatology

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