Psoriatic arthritis under the influence of IFNγ

    Research output: Contribution to journalReview article

    Abstract

    Psoriasis is a common multifactorial autoimmune disease of the skin, and in a large percentage of patients, immune responses involve nail and joint pathology, which develop psoriatic arthritis (PsA). Historically, T helper 1 (Th1)-derived-IFN-γ was abundantly detected in psoriatic skin and its correlation with development and severity of PsO, led to an early classification of psoriasis as a Th1-mediated disease. Investigations of the cellular and molecular mechanisms of PsO pathogenesis in recent years, together with impressive results of biologics against interleukin 17A (IL-17) have shifted focus on IL-17A. However, the contributions of IFN-γ in IL-17 induced pathology and its involvement in the development of PsA have been largely overshadowed. This review summarizes the current knowledge on IFN-γ and provides new insights on the contribution of IFN-γ to PsO and PsA disease pathogenesis and development.

    Original languageEnglish (US)
    Article number108513
    JournalClinical Immunology
    Volume218
    DOIs
    StatePublished - Sep 2020

    Keywords

    • IFN-γ
    • IL-17A
    • Keratinocyte
    • Osteoclast
    • Psoriasis
    • Psoriatic arthritis

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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