Prss16 is not required for T-cell development

Saijai Cheunsuk, Zhe Xiong Lian, Guo Xiang Yang, M. Eric Gershwin, Jeffrey R. Gruen, Christopher Bowlus

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


PRSS16 is a serine protease expressed exclusively in cortical thymic epithelial cells (cTEC) of the thymus, suggesting that it plays a role in the processing of peptide antigens during the positive selection of T cells. Moreover, the human PRSS16 gene is encoded in a region near the class I major histocompatibility complex (MHC) that has been linked to type 1 diabetes mellitus susceptibility. The mouse orthologue Prss16 is conserved in genetic structure, sequence, and pattern of expression. To study the role of Prss16 in thymic development, we generated a deletion mutant of Prss16 and characterized T-lymphocyte populations and MHC class II expression on cortical thymic epithelial cells. Prss16-deficient mice develop normally, are fertile, and show normal thymic morphology, cellularity, and anatomy. The total numbers and frequencies of thymocytes and splenic T-cell populations did not differ from those of wild-type controls. Surface expression of MHC class II on cTEC was also similar in homozygous mutant and wild-type animals, and invariant chain degradation was not impaired by deletion of Prss16. These findings suggest that Prss16 is not required for quantitatively normal T-cell development.

Original languageEnglish (US)
Pages (from-to)789-796
Number of pages8
JournalMolecular and Cellular Biology
Issue number2
StatePublished - Jan 2005

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology


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